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Open Access | Radical curative efficacy of tafenoquine combination regimens in Plasmodium cynomolgi-infected Rhesus monkeys (Macaca mulatta)

August 3, 2011 - 06:50 -- Kabogo Ndegwa
Dow GS, Gettayacamin M, Hansukjariya P, Imerbsin R, Komcharoen S, Sattabongkot J, Kyle D, Milhous W, Cozens S, Kenworthy D, Miller A, Veazey J, Ohrt C
Malaria Journal 2011, 10:212 (29 July 2011)

Ten-fold lower clinical doses of tafenoquine than used in prior studies may be effective against P. vivax hypnozoites if the drug is deployed in combination with effective blood-schizonticidal drugs.

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Tafenoquine, an Antiplasmodial 8-Aminoquinoline, Targets Leishmania Respiratory Complex III and Induces Apoptosis

November 19, 2010 - 11:33 -- Kabogo Ndegwa
Luis Carvalho, Juan Román Luque-Ortega, José Ignacio Manzano, Santiago Castanys, Luis Rivas, and Francisco Gamarro
Antimicrobial Agents and Chemotherapy, December 2010, p. 5344-5351, Vol. 54, No. 12

Tafenoquine (TFQ), an 8-aminoquinoline analogue of primaquine, which is currently under clinical trial (phase IIb/III) for the treatment and prevention of malaria, may represent an alternative treatment for leishmaniasis.

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Clinical Therapeutics: Randomized, Double-Blind Study of the Safety, Tolerability, and Efficacy of Tafenoquine versus Mefloquine for Malaria Prophylaxis in Nonimmune Subjects{triangledown}

January 28, 2010 - 12:14 -- Kabogo Ndegwa
Peter E. Nasveld, Michael D. Edstein, Mark Reid, Leonard Brennan, Ivor E. Harris, Scott J. Kitchener, Peter A. Leggat, Philip Pickford, Caron Kerr, Colin Ohrt, William Prescott, and the Tafenoquine Study Team
Antimicrobial Agents and Chemotherapy, February 2010, p. 792-798, Vol. 54, No. 2

This study represents the first phase III trial of the safety, tolerability, and effectiveness of tafenoquine for malaria prophylaxis.

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