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antimalarials

NOT Open Access | Effect of Coadministered Fat on the Tolerability, Safety, and Pharmacokinetic Properties of Dihydroartemisinin-Piperaquine in Papua New Guinean Children with Uncomplicated Malaria

September 19, 2014 - 06:02 -- NOT Open Access
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Author(s): 
B. R. Moore, J. M. Benjamin, S. Salman, S. Griffin, E. Ginny, M. Page-Sharp, L. J. Robinson, P. Siba, K. T. Batty, I. Mueller, and T. M. E. Davis
Reference: 
Antimicrob. Agents Chemother. October 2014 vol. 58 no. 10 5784-5794

Coadministration of dihydroartemisinin-piperaquine (DHA-PQ) with fat may improve bioavailability and antimalarial efficacy, but it might also increase toxicity.

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Protective Efficacy and Safety of Three Antimalarial Regimens for the Prevention of Malaria in Young Ugandan Children: A Randomized Controlled Trial

September 4, 2014 - 11:48 -- Open Access
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Author(s): 
Victor Bigira, James Kapisi, Grant Dorsey, et al.
Reference: 
PLoS Med 11(8): e1001689

For preventing malaria in children living in an area of high transmission intensity, monthly DP was the most efficacious and safe, although adherence may pose a problem.

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NOT Open Access | In search of next generation antimalarials

August 27, 2014 - 14:11 -- NOT Open Access
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Author(s): 
Sankar Chatterjee, Keiichi Tanabe, Edward A. Nodiff
Reference: 
Bioorganic & Medicinal Chemistry Letters Volume 24, Issue 17, 1 September 2014, Pages 4106–4109

Compounds 7–10 displayed potency without any apparent toxicity

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KAF156 Is an Antimalarial Clinical Candidate with Potential for Use in Prophylaxis, Treatment, and Prevention of Disease Transmission

August 19, 2014 - 14:10 -- Open Access
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Author(s): 
Kelli L. Kuhen, Arnab K. Chatterjee, Thierry T. Diagana, et al.
Reference: 
Antimicrob. Agents Chemother. September 2014 vol. 58 no. 9 5060-5067

Renewed global efforts toward malaria eradication have highlighted the need for novel antimalarial agents with activity against multiple stages of the parasite life cycle.

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New Insight into the Mechanism of Accumulation and Intraerythrocytic Compartmentation of Albitiazolium, a New Type of Antimalarial

August 19, 2014 - 14:09 -- Open Access
Author(s): 
Sharon Wein, Christophe Tran Van Ba, Marjorie Maynadier, Yann Bordat, Julie Perez, Suzanne Peyrottes, Laurent Fraisse, and Henri J. Vial
Reference: 
Antimicrob. Agents Chemother. September 2014 vol. 58 no. 9 5519-5527

Bis-thiazolium salts constitute a new class of antihematozoan drugs that inhibit parasite phosphatidylcholine biosynthesis.

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NOT Open Access | Antimalarial efficacy of dynamic compound of plumbagin chemical constituent from Plumbago zeylanica Linn (Plumbaginaceae) against the malarial vector Anopheles stephensi Liston (Diptera: Culicidae)

August 4, 2014 - 12:37 -- NOT Open Access
Author(s): 
Venkatraman Pradeepa , Subbiah Sathish-Narayanan , Suyambulingam Arunachalam Kirubakaran & Sengottayan Senthil-Nathan
Reference: 
Parasitology Research August 2014, Volume 113, Issue 8, pp 3105-3109

In the present investigation, the effective root compound of plumbagin of Plumbago zeylanica (Plumbaginaceae) was evaluated for chemical constituent and antimalarial effect against the fourth instar larvae of Anopheles stephensi Liston (Diptera).

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NOT Open Access | A better resolution for integrating methods for monitoring Plasmodium falciparum resistance to antimalarial drugs

July 26, 2014 - 04:54 -- NOT Open Access
Author(s): 
Rashad Abdul-Ghani, Mohamed T. Al-Maktari, Latifa A. Al-Shibani, Amal F. Allam
Reference: 
Acta Tropica, Volume 137, September 2014, Pages 44–57

Effective chemotherapy is the mainstay of malaria control.

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Return of chloroquine-sensitive Plasmodium falciparum parasites and emergence of chloroquine-resistant Plasmodium vivax in Ethiopia

July 3, 2014 - 11:54 -- Open Access
Author(s): 
Kebede S, Medhin G, Berhe N, Teklehaymanot T, Gebru T, Clause R, Velavan TP, Aseffa A
Reference: 
Malaria Journal 2014, 13 :244 (25 June 2014)

The study reports for the first time the return of chloroquine sensitive P. falciparum in Ethiopia.

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NOT Open Access | Novel synthetic route for antimalarial benzo[a]phenoxazine derivative SSJ-183 and two active metabolites

July 1, 2014 - 12:38 -- NOT Open Access
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Author(s): 
Yuki Mizukawa, Jian-Feng Ge, Abu Bakar Md, Isamu Itoh, Christian Scheurer, Sergio Wittlin, Reto Brun, Hiroyuki Matsuoka, Masataka Ihara
Reference: 
Bioorganic & Medicinal Chemistry, Volume 22, Issue 14, 15 July 2014, Pages 3749–3752

A productive synthesis of benzo[a]phenoxazine derivative SSJ-183 (1), a promising lead for antimalarial agents, was developed using a one pot procedure.

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Malaria Chemoprophylaxis with Atovaquone-Proguanil: Is a Shorter Regimen Fully Protective?

June 24, 2014 - 07:09 -- Open Access
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Author(s): 
Martin P. Grobusch
Reference: 
Journal of Travel Medicine, Volume 21, Issue 2, pages 79–81, March/April 2014

As in any other field of medicine, how much evidence do we need in travel medicine before we change daily practice and adapt guidelines and recommendations for prophylaxis or treatment, for example regarding malaria?

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