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antimalarials

NOT Open Access | Antimalarial Iron Chelator FBS0701 Blocks Transmission by Plasmodium falciparum Gametocyte Activation Inhibition

February 18, 2015 - 12:56 -- NOT Open Access
Author(s): 
Patricia Ferrer, Joel Vega-Rodriguez, Abhai K. Tripathi, Marcelo Jacobs-Lorena, and David J. Sullivan Jr.
Reference: 
Antimicrob. Agents Chemother. March 2015 vol. 59 no. 3 1418-1426

Reducing the transmission of the malarial parasite by Anopheles mosquitoes using drugs or vaccines remains a main focus in the efforts to control malaria.

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NOT Open Access | Potent Plasmodium falciparum Gametocytocidal Activity of Diaminonaphthoquinones, Lead Antimalarial Chemotypes Identified in an Antimalarial Compound Screen

February 18, 2015 - 12:55 -- NOT Open Access
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Author(s): 
Takeshi Q Tanaka, W. Armand Guiguemde, David S. Barnett, Maxim I. Maron, Jaeki Min, Michele C. Connelly, Praveen Kumar Suryadevara, R. Kiplin Guy, and Kim C. Williamson
Reference: 
Antimicrob. Agents Chemother. March 2015 vol. 59 no. 3 1389-1397

Forty percent of the world's population is threatened by malaria, which is caused by Plasmodium parasites and results in an estimated 200 million clinical cases and 650,000 deaths each year.

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Histone Methyltransferase Inhibitors Are Orally Bioavailable, Fast-Acting Molecules with Activity against Different Species Causing Malaria in Humans

January 28, 2015 - 16:19 -- Open Access
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Author(s): 
Nicholas A. Malmquist, Sandeep Sundriyal, Artur Scherf, et al.
Reference: 
Antimicrob. Agents Chemother. February 2015 vol. 59 no. 2 950-959

Current antimalarials are under continuous threat due to the relentless development of drug resistance by malaria parasites.

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NOT Open Access | Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo

January 7, 2015 - 09:26 -- NOT Open Access
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Author(s): 
Eva Maria Novoa, Noelia Camacho, Lluís Ribas de Pouplana, et al.
Reference: 
PNAS December 23, 2014 vol. 111 no. 51 E5508-E5517

Malaria remains a major global health problem.

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NOT Open Access | The synthesis, antimalarial activity and CoMFA analysis of novel aminoalkylated quercetin analogs

January 7, 2015 - 09:24 -- NOT Open Access
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Author(s): 
Travis R. Helgren, Richard J. Sciotti, Patricia Lee, Sandra Duffy, Vicky M. Avery, Osayawemwen Igbinoba, Matthew Akoto, Timothy J. Hagen
Reference: 
Bioorganic & Medicinal Chemistry Letters Volume 25, Issue 2, 15 January 2015, Pages 327–332

A series of novel aminoalkylated quercetin analogs, prepared via the Mannich reaction of various primary and secondary amines with formaldehyde, were tested for antimalarial activity.

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"Every drug goes to treat its own disease..." - a qualitative study of perceptions and experiences of taking anti-retrovirals concomitantly with anti-malarials among those affected by HIV and malaria in Tanzania

December 18, 2014 - 09:12 -- Open Access
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Author(s): 
Mangesho PE, Reynolds J, Lemnge M, Vestergaard LS, Chandler CI
Reference: 
Malaria Journal 2014, 13 :491 (13 December 2014)

Management of HIV and malaria concurrently often requires individuals to cross the domains of different disease programmes.

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NOT Open Access | Comparison of hematin-targeting properties of pynacrine, an acridine analog of the benzonaphthyridine antimalarial pyronaridine

November 19, 2014 - 15:42 -- NOT Open Access
Author(s): 
Narumon Sereekhajornjaru, Chanat Somboon, Roonglawan Rattanajak, William A. Denny, Prapin Wilairat, Saranya Auparakkitanon
Reference: 
Acta Tropica Volume 140, December 2014, Pages 181–183

The hematin-targeting properties of pynacrine, an acridine analog of the schizontocidal antimalarial drug, pyronaridine, were evaluated to probe the role of the latter's benzonaphthyridine moiety.

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NOT Open Access | Antimalarial activity of abietane ferruginol analogues possessing a phthalimide group

November 4, 2014 - 05:53 -- NOT Open Access
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Author(s): 
Miguel A. González, Julie Clark, Michele Connelly, Fatima Rivas
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 24, Issue 22, 15 November 2014, Pages 5234–5237

The abietane-type diterpenoid (+)-ferruginol, a bioactive compound isolated from New Zealand’s Miro tree (Podocarpus ferruginea), displays relevant pharmacological properties, including antimicrobial, cardioprotective, anti-oxidative, anti-plasmodial, leishmanicidal, anti-ulcerogenic, anti-inflammatory and anticancer.

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In Vitro Susceptibility of Plasmodium vivax to Antimalarials in Colombia

October 27, 2014 - 09:06 -- Open Access
Author(s): 
Diana Fernández, César Segura, Margarita Arboleda, Giovanny Garavito, Silvia Blair, and Adriana Pabón
Reference: 
Antimicrob. Agents Chemother. November 2014 vol. 58 no. 11 6354-6359

The in vitro susceptibilities of 30 isolates of Plasmodium vivax to a number of antimalarials (chloroquine [CQ], mefloquine, amodiaquine, quinine, and artesunate [AS]) were evaluated.

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NOT Open Access | Highly potent anti-proliferative effects of a gallium(III) complex with 7-chloroquinoline thiosemicarbazone as a ligand: Synthesis, cytotoxic and antimalarial evaluation

October 6, 2014 - 08:59 -- NOT Open Access
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Author(s): 
Kewal Kumar, Sarah Schniper, Vipan Kumar, et al.
Reference: 
European Journal of Medicinal Chemistry Volume 86, 30 October 2014, Pages 81–86

A gallium(III) complex with 7-chloroquinoline thiosemicarbazone was synthesized and characterized.

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