The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10237 malaria professionals are enjoying the free benefits of MalariaWorld today

antimalarials

Discovery of Novel Liver-Stage Antimalarials through Quantum Similarity

May 19, 2015 - 06:20 -- Open Access
Author(s): 
David J. Sullivan, Yi Liu, Bryan T. Mott, Nikola Kaludov, Martin N. Martinov
Reference: 
PLoS ONE 10(5): e0125593

Without quantum theory any understanding of molecular interactions is incomplete.

Medical Treatment: 

NOT Open Access | In Vivo Antimalarial Activity and Mechanisms of Action of 4-Nerolidylcatechol Derivatives

May 18, 2015 - 13:08 -- NOT Open Access
Tags: 
Author(s): 
Luiz Francisco Rocha e Silva, Karla Lagos Nogueira, Adrian Martin Pohlit, et al.
Reference: 
Antimicrob. Agents Chemother. June 2015 vol. 59 no. 6 3271-3280

4-Nerolidylcatechol (1) is an abundant antiplasmodial metabolite that is isolated from Piper peltatum roots.

Medical Treatment: 

NOT Open Access | In Vitro Antimalarial Activity of Novel Semisynthetic Nocathiacin I Antibiotics

May 18, 2015 - 13:06 -- NOT Open Access
Author(s): 
Indu Sharma, Margery Sullivan, and Thomas F. McCutchan
Reference: 
Antimicrob. Agents Chemother. June 2015 vol. 59 no. 6 3174-3179

Presently, the arsenal of antimalarial drugs is limited and needs to be replenished. We evaluated the potential antimalarial activity of two water-soluble derivatives of nocathiacin (BMS461996 and BMS411886) against the asexual blood stages of Plasmodium falciparum.

Medical Treatment: 

Development of two novel high-throughput assays to quantify ubiquitylated proteins in cell lysates: application to screening of new anti-malarials

May 18, 2015 - 12:21 -- Open Access
Tags: 
Author(s): 
Lydia Mata-Cantero, Concepción Cid, Maria G Gomez-Lorenzo, Wendy Xolalpa, Fabienne Aillet, J Martín, Manuel S Rodriguez
Reference: 
Malaria Journal 2015, 14:200 (14 May 2015)

The two assays presented can be used in a high-throughput format to find new UPS inhibitors for P. falciparum and could help to identify new targets within this system.

Medical Treatment: 

NOT Open Access | Mechanisms of hematin crystallization and inhibition by the antimalarial drug chloroquine

April 24, 2015 - 06:46 -- NOT Open Access
Tags: 
Author(s): 
Katy N. Olafson, Megan A. Ketchum, Jeffrey D. Rimer, and Peter G. Vekilov
Reference: 
PNAS April 21, 2015 vol. 112 no. 16 4946-4951

Hematin crystallization is the primary mechanism of heme detoxification in malaria parasites and the target of the quinoline class of antimalarials.

Medical Treatment: 

Imported malaria among people who travel to visit friends and relatives: is current UK policy effective or does it need a strategic change?

April 14, 2015 - 18:39 -- Open Access
Tags: 
Author(s): 
Behrens RH, Neave PE, Jones C
Reference: 
Malaria Journal 2015, 14 :149 (9 April 2015)

Potential alternative strategies include the use of standby emergency-treatment (SBET) for the management of fevers with an anti-malarial provided pre-travel, the provision of rapid diagnostic testing and treatment regimen based in general-practitioner surgeries, and urgent and walk-in care centres and local accident and emergency (A&E) departments to provide immediate diagnosis and accessible ambulatory treatment for malaria patients.

Medical Treatment: 

NOT Open Access | New heterocyclic hybrids of pyrazole and its bioisosteres: Design, synthesis and biological evaluation as dual acting antimalarial-antileishmanial agents

April 3, 2015 - 10:03 -- NOT Open Access
Tags: 
Author(s): 
Adnan A. Bekhit, Ahmed M.M. Hassan, Heba A. Abd El Razik, Mostafa M.M. El-Miligy, Eman J. El-Agroudy, Alaa El-Din A. Bekhit
Reference: 
European Journal of Medicinal Chemistry, Volume 94, 13 April 2015, Pages 30–44

A new series of pyrazole derivatives were synthesized by hybridization with five-membered heterocyclic moieties such as thiazoles, thiazolidinones, 1,3,4-thiadiazoles and pyrazolines.

Medical Treatment: 

Anti-malarial activity and toxicity assessment of Himatanthus articulatus, a plant used to treat malaria in the Brazilian Amazon

March 31, 2015 - 17:38 -- Open Access
Author(s): 
Valdicley V Vale, Thyago C Vilhena, lávio De Vasconcelos, et al.
Reference: 
Malaria Journal 2015, 14:132 (27 March 2015)

The ethanol extract of H. articulatus proved to be promising as anti-malarial medicine and showed low toxicity.

Country: 
Medical Condition: 
Medical Treatment: 

NOT Open Access | Design, synthesis and biological evaluation of functionalized phthalimides: A new class of antimalarials and inhibitors of falcipain-2, a major hemoglobinase of malaria parasite

March 26, 2015 - 10:25 -- NOT Open Access
Author(s): 
Anil K. Singh, Vinoth Rajendran, Akansha Pant, Prahlad C. Ghosh, Neelu Singh, N. Latha, Sandeep Garg, Kailash C. Pandey, Brajendra K. Singh, Brijesh Rathi
Reference: 
Bioorganic & Medicinal Chemistry, Volume 23, Issue 8, 15 April 2015, Pages 1817–1827

Phthalimides functionalized with cyclic amines were synthesized, characterized and screened for their in vitro antimalarial efficacy against Plasmodium falciparum (Pf3D7).

Medical Treatment: 

NOT Open Access | Determination of the active stereoisomer of the MEP pathway-targeting antimalarial agent MMV008138, and initial structure–activity studies

March 25, 2015 - 15:49 -- NOT Open Access
Author(s): 
Zhong-Ke Yao, Priscilla M. Krai, Emilio F. Merino, Morgan E. Simpson, Carla Slebodnick, Maria Belen Cassera, Paul R. Carlier
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 25, Issue 7, 1 April 2015, Pages 1515–1519

Compounds that target isoprenoid biosynthesis in Plasmodium falciparum could be a welcome addition to malaria chemotherapy, since the methylerythritol phosphate (MEP) pathway used by the parasite is not present in humans.

Medical Treatment: 

Pages

Subscribe to RSS - antimalarials