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antimalarials

NOT Open Access | Use of bacterial surrogates as a tool to explore antimalarial drug interaction: Synergism between inhibitors of malarial dihydrofolate reductase and dihydropteroate synthase

August 5, 2015 - 09:15 -- NOT Open Access
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Author(s): 
Yuwadee Talawanich, Sumalee Kamchonwongpaisan, Worachart Sirawaraporn, Yongyuth Yuthavong
Reference: 
Acta Tropica, Volume 149, September 2015, Pages 64–69

Interaction between antimalarial drugs is important in determining the outcome of chemotherapy using drug combinations.

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NOT Open Access | Anti-malarials are anti-cancers and vice versa – One arrow two sparrows

August 5, 2015 - 09:14 -- NOT Open Access
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Author(s): 
Chanakya Nath Kundu, Sarita Das, Anmada Nayak, Shakti Ranjan Satapathy, Dipon Das, Sumit Siddharth
Reference: 
Acta Tropica, Volume 149, September 2015, Pages 113–127

Repurposing is the novel means of drug discovery in modern science due to its affordability, safety and availability.

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Measuring windows of selection for anti-malarial drug treatments

August 5, 2015 - 09:04 -- Open Access
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Author(s): 
Katherine Kay, Ian M Hastings
Reference: 
Malaria Journal 2015, 14:292 (31 July 2015)

Previous studies, based on clinically observed WoS, have probably underestimated the ‘true’ WoS and hence the role of drugs with long half-lives in driving resistance.

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NOT Open Access | Modified quaternary ammonium salts as potential antimalarial agents

July 27, 2015 - 18:09 -- NOT Open Access
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Author(s): 
Nicoletta Basilico, Mara Migotto, Denise Patoinewende Ilboudo, Donatella Taramelli, Riccardo Stradi, Elena Pini
Reference: 
Bioorganic & Medicinal Chemistry, Volume 23, Issue 15, 1 August 2015, Pages 4681–4687

A series of new quaternary ammonium salts containing a polyconjugated moiety has been synthesized and characterized; their biological activity as potential antimalarial agents was investigated, as well.

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NOT Open Access | Glycosyl hydroperoxides: A new class of potential antimalarial agents

June 9, 2015 - 08:55 -- NOT Open Access
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Author(s): 
Barbara Szechner, Anna Jaromin, Silvia Parapini, Nicoletta Basilico, Barbara Grzeszczyk, Bartłomiej Furman, Marek Chmielewski
Reference: 
Bioorganic & Medicinal Chemistry, Volume 23, Issue 13, 1 July 2015, Pages 3033–3039

Motivated by the antimalarial properties observed in organic peroxides, an extensive series of glycosyl hydroperoxides was prepared with the aim of identifying new bioactive molecules

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Development of a genetic tool for functional screening of anti-malarial bioactive extracts in metagenomic libraries

June 4, 2015 - 08:20 -- Open Access
Author(s): 
Alvaro Mongui, Francy Pérez-Llanos, Marcio Yamamoto, Marcela Lozano, Maria Zambrano, Patricia Del Portillo, Carmen Fernández-Becerra, Silvia Restrepo, Hernando Del Portillo, Howard Junca
Reference: 
Malaria Journal 2015, 14:233 (4 June 2015)

Here, a new technical platform to access the anti-malarial potential in microbial environmental metagenomes has been developed.

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NOT Open Access | Malaria medicines: a glass half full?

June 2, 2015 - 13:49 -- NOT Open Access
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Author(s): 
Timothy N. C. Wells, Rob Hooft van Huijsduijnen & Wesley C. Van Voorhis
Reference: 
Nature Reviews Drug Discovery 14, 424-442 (June 2015)

Despite considerable advances in malaria medicines in the past 20 years, the global burden of malaria remains substantial.

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Enhanced surveillance and data feedback loop associated with improved malaria data in Lusaka, Zambia

June 2, 2015 - 06:56 -- Open Access
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Author(s): 
Zunda Chisha, David Larsen, Anna Winters, et al.
Reference: 
Malaria Journal 2015, 14:222 (29 May 2015)

Enhanced surveillance and implementation of a data feedback loop have substantially increased malaria testing rates and decreased the number of unconfirmed malaria cases and courses of ACT consumed in Lusaka District within just two years.

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Intervals to Plasmodium falciparum recurrence after anti-malarial treatment in pregnancy: a longitudinal prospective cohort

June 2, 2015 - 06:44 -- Open Access
Author(s): 
Natthapon Laochan, Sophie Zaloumis, Mallika Imwong, Usa Lek-Uthai, Alan Brockman, Kanlaya Sriprawat, Jacher Wiladphaingern, Nicholas White, François Nosten, Rose McGready
Reference: 
Malaria Journal 2015, 14:221 (28 May 2015)

Prolonged time to recrudescence may occur in pregnancy, regardless of anti-malarial treatment.

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From METS to malaria: RRx-001, a multi-faceted anticancer agent with activity in cerebral malaria

June 2, 2015 - 06:26 -- Open Access
Author(s): 
Ozlem Yalcin, Bryan Oronsky, Leonardo Carvalho, Frans Kuypers, Jan Scicinski, Pedro Cabrales
Reference: 
Malaria Journal 2015, 14:218 (28 May 2015)

The results indicate that RRx-001 could be used to potentiate the anti-malarial action of artemisinin, particularly on resistant strains, and to prevent infection.

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