Interaction between antimalarial drugs is important in determining the outcome of chemotherapy using drug combinations.
Repurposing is the novel means of drug discovery in modern science due to its affordability, safety and availability.
Previous studies, based on clinically observed WoS, have probably underestimated the ‘true’ WoS and hence the role of drugs with long half-lives in driving resistance.
A series of new quaternary ammonium salts containing a polyconjugated moiety has been synthesized and characterized; their biological activity as potential antimalarial agents was investigated, as well.
Motivated by the antimalarial properties observed in organic peroxides, an extensive series of glycosyl hydroperoxides was prepared with the aim of identifying new bioactive molecules
Here, a new technical platform to access the anti-malarial potential in microbial environmental metagenomes has been developed.
Despite considerable advances in malaria medicines in the past 20 years, the global burden of malaria remains substantial.
Enhanced surveillance and implementation of a data feedback loop have substantially increased malaria testing rates and decreased the number of unconfirmed malaria cases and courses of ACT consumed in Lusaka District within just two years.
Prolonged time to recrudescence may occur in pregnancy, regardless of anti-malarial treatment.
The results indicate that RRx-001 could be used to potentiate the anti-malarial action of artemisinin, particularly on resistant strains, and to prevent infection.