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antimalarials

Supporting malaria elimination with 21st century antimalarial agent drug discovery

October 20, 2015 - 07:30 -- Open Access
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Author(s): 
Thierry T. Diagana
Reference: 
Drug Discovery Today, Volume 20, Issue 10, October 2015, Pages 1265–1270

The burden of malaria has been considerably reduced over recent years.

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NOT Open Access | Novel 1,4-naphthoquinone-based sulfonamides: Synthesis, QSAR, anticancer and antimalarial studies

October 14, 2015 - 10:28 -- NOT Open Access
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Author(s): 
Ratchanok Pingaew, Veda Prachayasittikul, Apilak Worachartcheewan, Chanin Nantasenamat, Supaluk Prachayasittikul, Somsak Ruchirawat, Virapong Prachayasittikul
Reference: 
European Journal of Medicinal Chemistry, Volume 103, 20 October 2015, Pages 446–459

A novel series of 1,4-naphthoquinones (33–44) tethered by open and closed chain sulfonamide moieties were designed, synthesized and evaluated for their cytotoxic and antimalarial activities.

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In Vivo Curative and Protective Potential of Orally Administered 5-Aminolevulinic Acid plus Ferrous Ion against Malaria

October 14, 2015 - 09:55 -- Open Access
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Author(s): 
Shigeo Suzuki, Kenji Hikosaka, Emmanuel O. Balogun, Keisuke Komatsuya, Mamoru Niikura, Fumie Kobayashi, Kiwamu Takahashi, Tohru Tanaka, Motowo Nakajima, and Kiyoshi Kita
Reference: 
Antimicrob. Agents Chemother. November 2015 vol. 59 no. 11 6960-6967

5-Aminolevulinic acid (ALA) is a naturally occurring amino acid present in diverse organisms and a precursor of heme biosynthesis.

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NOT Open Access | Targeting protein translation, RNA splicing, and degradation by morpholino-based conjugates in Plasmodium falciparum

September 23, 2015 - 16:42 -- NOT Open Access
Author(s): 
Aprajita Garg, Donna Wesolowski, Dulce Alonso, Kirk W. Deitsch, Choukri Ben Mamoun, and Sidney Altman
Reference: 
PNAS September 22, 2015 vol. 112 no. 38 11935-11940

Identification and genetic validation of new targets from available genome sequences are critical steps toward the development of new potent and selective antimalarials.

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NOT Open Access | Fusion of field studies and the laboratory solves a puzzle in antimalarial resistance

September 16, 2015 - 13:21 -- NOT Open Access
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Author(s): 
Carol Hopkins Sibley and Kristin D. Lane
Reference: 
PNAS September 15, 2015 vol. 112 no. 37 11432-11433

The study of evolutionary processes is necessarily retrospective, but past pathways can lull us into imagining that future changes will generally follow the same trajectory.

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NOT Open Access | Antimalarial and antioxidant activities of Indigofera oblongifolia on Plasmodium chabaudi-induced spleen tissue injury in mice

September 3, 2015 - 05:14 -- NOT Open Access
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Author(s): 
Mahmoud Y. Lubbad, Saleh Al-Quraishy & Mohamed A. Dkhil
Reference: 
Parasitology Research, September 2015, Volume 114, Issue 9, pp 3431-3438

Malaria is still one of the most common infectious diseases and leads to various public health problems worldwide.

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Genetic determinants of anti-malarial acquired immunity in a large multi-centre study

August 31, 2015 - 16:03 -- Open Access
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Author(s): 
Jennifer M G Shelton, Patrick Corran, Kirk A Rockett, et al.
Reference: 
Malaria Journal 2015, 14:333 (28 August 2015)

Although the most significant finding with a consistent effect across sites was for sickle cell trait, its effect is likely to be via reducing a microscopically positive parasitaemia rather than directly on antibody levels.

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Anti-malarial prescription practices among children admitted to six public hospitals in Uganda from 2011 to 2013

August 31, 2015 - 15:59 -- Open Access
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Author(s): 
Asadu Sserwanga, David Sears, Arthur Mpimbaza, et al.
Reference: 
Malaria Journal 2015, 14:331 (27 August 2015)

Despite high testing rates for malaria at all sites, prescription of anti-malarials to patients with negative test results remained high, with the exception of one site where a steady decline occurred.

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NOT Open Access | From hybrid compounds to targeted drug delivery in antimalarial therapy

August 12, 2015 - 14:29 -- NOT Open Access
Author(s): 
Rudi Oliveira, Daniela Miranda, Joana Magalhães, Rita Capela, Maria J. Perry, Paul M. O’Neill, Rui Moreira, Francisca Lopes
Reference: 
Bioorganic & Medicinal Chemistry, Volume 23, Issue 16, 15 August 2015, Pages 5120–5130

The discovery of new drugs to treat malaria is a continuous effort for medicinal chemists due to the emergence and spread of resistant strains of Plasmodium falciparum to nearly all used antimalarials.

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NOT Open Access | In vivo Antimalarial Activity of α-Mangostin and the New Xanthone δ-Mangostin

August 12, 2015 - 06:20 -- NOT Open Access
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Author(s): 
Yulieth Upegui, Sara M. Robledo, Juan Fernando Gil Romero, Winston Quiñones, Rosendo Archbold, Fernando Torres, Gustavo Escobar, Bibiana Nariño and Fernando Echeverri
Reference: 
Phytotherapy Research, Volume 29, Issue 8, pages 1195–1201, August 2015

Based on the previously reported in vitro antiplasmodial activity of several xanthones from Garcinia mangostana, two xanthones, α-mangostin and a new compound, δ-mangostin, were isolated from mangosteen husk, and the in vitro antiplasmodial and cytotoxic effects were determined.

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