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antimalarials

Manadoperoxides A-D from the Indonesian Sponge Plakortis cfr. simplex. Further Insights on the Structure-Activity Relationships of Simple 1,2-Dioxane Antimalarials

June 9, 2010 - 08:01 -- Kabogo Ndegwa
Author(s): 
C Fattorusso, M Persico, B Calcinai, C Cerrano, S Parapini, D Taramelli, E Novellino, A Romano, F Scala, E Fattorusso, O Taglialatela-Scafati
Reference: 
J. Nat. Prod. June 3, 2010

The new endoperoxyketal polyketides manadoperoxides A−D (2−5) have been isolated from the Indonesian sponge Plakortis cfr. simplex and their stereostructures established by means of spectroscopic data and semisynthetic transformations.

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Policy brief on improving access to artemisinin-based combination therapies for malaria in the East African community

April 20, 2010 - 14:55 -- Patrick Sampao
Author(s): 
Harriet Nabuderea, Gabriel L. Upundaa and Malick Jumaa
Reference: 
International Journal of Technology Assessment in Health Care 26 : 255-259 2010

To scale up the use of ACTs in the East African region to combat malaria and speed up progress toward the sixth Millennium Development Goal, a combination of delivery, financial, and governance arrangements tailored to national or subnational contexts needs to be considered.

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Gomphostenins: Two new antimalarial compounds from the leaves of Gomphostemma niveum

January 28, 2010 - 12:09 -- Kabogo Ndegwa
Author(s): 
Manisha Sathe and M.P. Kaushik
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 3, 1 February 2010, Pages 1312-1314

Phytochemical investigation of CHCl3 extract of the Gomphostemma niveum leaves led to the isolation of two new diterpene, compound 1 and 2. Their structures were elucidated by spectroscopic procedures and single crystal XRD.

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