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antimalarials

NOT Open Access | Synthesis of antimalarial amide analogues based on the plant serrulatane diterpenoid 3,7,8-trihydroxyserrulat-14-en-19-oic acid

August 23, 2017 - 16:03 -- NOT Open Access
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Author(s): 
Rohitesh Kumar, Sandra Duffy, Vicky M. Avery, Rohan A. Davis
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 27, Issue 17, 1 September 2017, Pages 4091-4095

A plant-derived natural product scaffold, 3,7,8-trihydroxyserrulat-14-en-19-oic acid (1) was isolated in high yield from the aerial parts of the endemic Australian desert plant Eremophila microtheca.

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NOT Open Access | Malaria overdiagnosis and subsequent overconsumption of antimalarial drugs in Angola: Consequences and effects on human health

June 20, 2017 - 14:34 -- NOT Open Access
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Author(s): 
Sylvie Manguin, Vincent Foumane, Patrick Besnard, Filomeno Fortes, Pierre Carnevale
Reference: 
Acta Tropica, Volume 171, July 2017, Pages 58–63

Microscopic blood smear examinations done in health centers of Angola demonstrated a large overdiagnosis of malaria cases with an average rate of errors as high as 85%.

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Mass anti-malarial administration in western Cambodia: a qualitative study of factors affecting coverage

May 25, 2017 - 08:07 -- Open Access
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Author(s): 
Christopher Pell, Rupam Tripura, Thomas J. Peto, et al.
Reference: 
Malaria Journal 2017 16:206, 19 May 2017

Future mass anti-malarial administration must consider seasonal disease patterns and the importance of local leaders taking prominent roles in community engagement.

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The effect of malaria and anti-malarial drugs on skeletal and cardiac muscles

November 8, 2016 - 17:09 -- Open Access
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Author(s): 
Mauro Toledo Marrelli and Marco Brotto
Reference: 
Malaria Journal 2016 15:524, 2 November 2016

Malaria remains one of the most important infectious diseases in the world, being a significant public health problem associated with poverty and it is one of the main obstacles to the economy of an endemic country.

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NOT Open Access | 7-Chloro-4-aminoquinoline γ-hydroxy-γ-lactam derived-tetramates as a new family of antimalarial compounds

November 8, 2016 - 16:58 -- NOT Open Access
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Author(s): 
Nicolas Chopin, Shinya Iikawa, Maurice Médebielle, et al.
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 26, Issue 21, 1 November 2016, Pages 5308–5311

In this Letter we report on an efficient and short 2–3 steps synthesis of γ-hydroxy-γ-lactam derived-tetramates bearing a 7-chloro-4-aminoquinoline skeleton and their evaluation as potent antimalarials.

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Not Open Access | Antimalarial potential of leaves of Chenopodium ambrosioides L

November 2, 2016 - 08:05 -- NOT Open Access
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Author(s): 
Dalila Nunes Cysne, Thiare Silva Fortes, Flávia Raquel Fernandes Nascimento, et al.
Reference: 
Parasitology Research, November 2016, Volume 115, Issue 11, pp 4327–4334

In an effort to identify novel therapeutic alternatives for the treatment of malaria, the present study evaluated the antimalarial effect of the crude hydroalcoholic extract (HCE) from the leaves of Chenopodium ambrosioides L.

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Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose–Efficacy Modeling

October 6, 2016 - 17:21 -- Open Access
Author(s): 
Amélie Le Bihan, Ruben de Kanter, Sergio Wittlin, et al.
Reference: 
PLoS Med 13(10): e1002138

The dual activity of ACT-451840 against asexual and sexual stages of P. falciparum and the activity on P. vivax have the potential to meet the specific profile of a target compound that could replace the fast-acting artemisinin component and harbor additional gametocytocidal activity and, thereby, transmission-blocking properties.

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The acceptability mass administrations of anti-malarial drug as part of targeted malaria elimination in villages along the Thai–Myanmar border

September 28, 2016 - 17:18 -- Open Access
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Author(s): 
Ladda Kajeechiwa, May Myo Thwin, Francois Nosten, et al.
Reference: 
Malaria Journal 2016 15:494, 27 September 2016

It is unlikely that community engagement can unite fragmented communities in participating in an intervention, which benefits the community.

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NOT Open Access | Lack of doxycycline antimalarial prophylaxis impact on Staphylococcus aureus tetracycline resistance

September 28, 2016 - 17:04 -- NOT Open Access
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Author(s): 
Katrin Mende, Miriam L. Beckius, Wendy C. Zera, Xin Yu, Ping Li, David R. Tribble, Clinton K. Murray
Reference: 
Diagnostic Microbiology and Infectious Disease Volume 86, Issue 2, October 2016, Pages 211–220

There is concern that susceptibility of Staphylococcus aureus to tetracyclines may decrease due to use of antimalarial prophylaxis (doxycycline).

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NOT Open Access | The Redox Cycler Plasmodione Is a Fast-Acting Antimalarial Lead Compound with Pronounced Activity against Sexual and Early Asexual Blood-Stage Parasites

September 3, 2016 - 16:24 -- NOT Open Access
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Author(s): 
Katharina Ehrhardt, Christiane Deregnaucourt, Elisabeth Davioud-Charvet, et al.
Reference: 
Antimicrob. Agents Chemother. September 2016 vol. 60 no. 9 5146-5158

Previously, we presented the chemical design of a promising series of antimalarial agents, 3-[substituted-benzyl]-menadiones, with potent in vitro and in vivo activities.

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