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antimalarials

Spectrophotometric detection of susceptibility to anti-malarial drugs

September 4, 2013 - 11:32 -- Open Access
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Author(s): 
Serebrennikova YM, Patel J, Milhous WK, Garcia-Rubio LH, Huffman DE, Smith JM
Reference: 
Malaria Journal 2013, 12:305 (30 August 2013)
MalariaWorld

The spectroscopic analysis method proved to be sensitive for recognition of the effects of anti-malarial treatment on the structure and composition of the parasites and IRBCs.

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NOT Open Access | HIV-Positive Nigerian Adults Harbor Significantly Higher Serum Lumefantrine Levels than HIV-Negative Individuals Seven Days after Treatment for Plasmodium falciparum Infection

August 22, 2013 - 08:47 -- NOT Open Access
Author(s): 
Ifeyinwa Chijioke-Nwauche, Albert van Wyk, Chijioke Nwauche, Khalid B. Beshir, Harparkash Kaur, and Colin J. Sutherland
Reference: 
Antimicrob. Agents Chemother. September 2013 vol. 57 no. 9 4146-4150
MalariaWorld

Management of coinfection with malaria and HIV is a major challenge to public health in developing countries, and yet potential drug-drug interactions between antimalarial and antiviral regimens have not been adequately investigated in people with both infections.

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Improving Pharmacokinetic-Pharmacodynamic Modeling to Investigate Anti-Infective Chemotherapy with Application to the Current Generation of Antimalarial Drugs

July 31, 2013 - 15:27 -- Open Access
Author(s): 
Katherine Kay, Ian M. Hastings
Reference: 
PLoS Comput Biol 9(7): e1003151
MalariaWorld

Mechanism-based pharmacokinetic-pharmacodynamic (PK/PD) modelling is the standard computational technique for simulating drug treatment of infectious diseases with the potential to enhance our understanding of drug treatment outcomes, drug deployment strategies, and dosing regimens.

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NOT Open Access | Broad-Spectrum Antimalarial Activity of Peptido Sulfonyl Fluorides, a New Class of Proteasome Inhibitors

July 17, 2013 - 13:26 -- NOT Open Access
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Author(s): 
Serena Tschan, Arwin J. Brouwer, Benjamin Mordmüller, et al.
Reference: 
Antimicrob. Agents Chemother. August 2013 vol. 57 no. 8 3576-3584
MalariaWorld

Despite declining numbers of cases and deaths, malaria remains a major public health problem in many parts of the world.

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Cell Wall Perturbation Sensitizes Fungi to the Antimalarial Drug Chloroquine

July 17, 2013 - 13:06 -- Open Access
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Author(s): 
Farida Islahudin, Combiz Khozoie, Steven Bates, Kang-Nee Ting, Richard J. Pleass, and Simon V. Avery
Reference: 
Antimicrob. Agents Chemother. 2013;57 3889-3896
MalariaWorld

Chloroquine (CQ) has been a mainstay of antimalarial drug treatment for several decades.

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Biological evaluation of hydroxynaphthoquinones as anti-malarials

July 17, 2013 - 12:29 -- Open Access
Author(s): 
Schuck DC, Ferreira SB, Cruz LN, da Rocha DR, Moraes M, Nakabashi M, Rosenthal PJ, Ferreira VF, Garcia CR
Reference: 
Malaria Journal 2013, 12:234 (10 July 2013)
MalariaWorld

N3 was a potent inhibitor of mitochondrial electron transport, had nanomolar activity against cultured Plasmodium falciparum and showed minimal cytotoxicity. N3 may serve as a starting point for the design of new hydroxynaphthoquinone anti-malarials.

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Anti-malarial property of steroidal alkaloid conessine isolated from the bark of Holarrhena antidysenterica

June 18, 2013 - 12:11 -- Open Access
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Author(s): 
Dua VK, Verma G, Singh B, Rajan A, Bagai U, Agarwal D, Gupta NC, Kumar S, Rastogi A
Reference: 
Malaria Journal 2013, 12:194 (10 June 2013)
MalariaWorld

The present investigation demonstrates that the compound conessine exhibited substantial anti-malarial property.

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NOT Open Access | In Vitro and In Vivo Antimalarial Efficacies of Optimized Tetracyclines

June 15, 2013 - 12:35 -- NOT Open Access
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Author(s): 
Michael P. Draper, Beena Bhatia, Mark L. Nelson, et al.
Reference: 
Antimicrob. Agents Chemother. July 2013 vol. 57 no. 7 3131-3136
MalariaWorld

With increasing resistance to existing antimalarials, there is an urgent need to discover new drugs at affordable prices for countries in which malaria is endemic.

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NOT Open Access | Modulation of PF10_0355 (MSPDBL2) Alters Plasmodium falciparum Response to Antimalarial Drugs

June 15, 2013 - 12:31 -- NOT Open Access
Author(s): 
Daria Van Tyne, Alessandro D. Uboldi, Julie Healer, Alan F. Cowman, and Dyann F. Wirth
Reference: 
Antimicrob. Agents Chemother. July 2013 vol. 57 no. 7 2937-2941
MalariaWorld

Malaria's ability to rapidly adapt to new drugs has allowed it to remain one of the most devastating infectious diseases of humans.

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Ivermectin to reduce malaria transmission: a research agenda for a promising new tool for elimination

May 8, 2013 - 11:56 -- Open Access
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Author(s): 
Chaccour CJ, Kobylinski KC, Bassat Q, Bousema T, Drakeley C, Alonso P, Foy BD
Reference: 
Malaria Journal 2013, 12:153 (7 May 2013)
MalariaWorld

The use of ivermectin solves many challenges identified for future vector control strategies.

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