The spectroscopic analysis method proved to be sensitive for recognition of the effects of anti-malarial treatment on the structure and composition of the parasites and IRBCs.
Management of coinfection with malaria and HIV is a major challenge to public health in developing countries, and yet potential drug-drug interactions between antimalarial and antiviral regimens have not been adequately investigated in people with both infections.
Mechanism-based pharmacokinetic-pharmacodynamic (PK/PD) modelling is the standard computational technique for simulating drug treatment of infectious diseases with the potential to enhance our understanding of drug treatment outcomes, drug deployment strategies, and dosing regimens.
Despite declining numbers of cases and deaths, malaria remains a major public health problem in many parts of the world.
Chloroquine (CQ) has been a mainstay of antimalarial drug treatment for several decades.
N3 was a potent inhibitor of mitochondrial electron transport, had nanomolar activity against cultured Plasmodium falciparum and showed minimal cytotoxicity. N3 may serve as a starting point for the design of new hydroxynaphthoquinone anti-malarials.
The present investigation demonstrates that the compound conessine exhibited substantial anti-malarial property.
With increasing resistance to existing antimalarials, there is an urgent need to discover new drugs at affordable prices for countries in which malaria is endemic.
Malaria's ability to rapidly adapt to new drugs has allowed it to remain one of the most devastating infectious diseases of humans.
The use of ivermectin solves many challenges identified for future vector control strategies.