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antimalarials

In vitro interaction of lumefantrine and piperaquine by atorvastatin against Plasmodium falciparum

June 9, 2014 - 16:30 -- Open Access
Author(s): 
Dormoi J, Savini H, Amalvict R, Baret E, Pradines B
Reference: 
Malaria Journal 2014, 13 :189 (25 May 2014)

Even though in vitro data indicate that atorvastatin improved the activity of lumefantrine and piperaquine, the same may not necessarily be true in vivo.

Medical Treatment: 

NOT Open Access | The role of antioxidants treatment on the pathogenesis of malarial infections: a review

March 7, 2014 - 10:50 -- NOT Open Access
Author(s): 
Murtala Bindawa Isah & Mohammed Auwal Ibrahim
Reference: 
Parasitology Research, March 2014, Volume 113, Issue 3, pp 801-809

Oxidative damage is one of the most important pathological consequences of malarial infections.

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NOT Open Access | 7-Chloroquinolinotriazoles: Synthesis by the azide–alkyne cycloaddition click chemistry, antimalarial activity, cytotoxicity and SAR studies

February 11, 2014 - 08:01 -- NOT Open Access
Tags: 
Author(s): 
Guilherme R. Pereira, Geraldo Célio Brandão, Lucas M. Arantes, Háliton A. de Oliveira, Renata Cristina de Paula, Maria Fernanda A. do Nascimento, Fábio M. dos Santos, Ramon K. da Rocha, Júlio César D. Lopes, Alaíde Braga de Oliveira
Reference: 
European Journal of Medicinal Chemistry, Volume 73, 12 February 2014, Pages 295–309

Twenty-seven 7-chloroquinolinotriazole derivatives with different substituents in the triazole moiety were synthesized via copper-catalyzed cycloaddition (CuAAC) click chemistry between 4-azido-7-chloroquinoline and several alkynes.

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Barriers to Malaria Control among Marginalized Tribal Communities: A Qualitative Study

January 2, 2014 - 08:52 -- Open Access
Tags: 
Author(s): 
Radhika Sundararajan, Yogeshwar Kalkonde, Charuta Gokhale, P. Gregg Greenough, Abhay Bang
Reference: 
PLoS ONE 8(12): e81966

Geographic, cultural, and social factors create barriers to malaria control among tribal communities in India.

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Prevention and management of malaria during pregnancy: findings from a comparative qualitative study in Ghana, Kenya and Malawi

November 26, 2013 - 13:19 -- Open Access
Author(s): 
Pell C, Meñaca A, Afrah NA, Manda-Taylor L, Chatio S, Were F, Hodgson A, Hamel MJ, Kalilani L, Tagbor H, Pool R
Reference: 
Malaria Journal 2013, 12 :427 (20 November 2013)
MalariaWorld

Although ITNs were valued as malaria prevention, health messages could address issues that reduce their use during pregnancy in particular contexts

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Survey of Plasmodium falciparum multidrug resistance-1 and chloroquine resistance transporter alleles in Haiti

November 26, 2013 - 13:17 -- Open Access
Author(s): 
ElBadry MA, Existe A, Victor YS, Memnon G, Fukuda M, Dame JB, Yowell CA, Okech BA
Reference: 
Malaria Journal 2013, 12 :426 (19 November 2013)
MalariaWorld

The presence of the Y184F mutation in pfmdr1 of P. falciparum parasites in Haiti may have implications for resistance to antimalarial drugs.

Country: 
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Susceptibility of human Plasmodium knowlesi infections to anti-malarials

November 26, 2013 - 13:15 -- Open Access
Author(s): 
Fatih FA, Staines HM, Siner A, Ahmed MA, Woon LC, Pasini EM, Kocken CH, Singh B, Cox-Singh J, Krishna S
Reference: 
Malaria Journal 2013, 12 :425 (19 November 2013)
MalariaWorld

Taken together with reports of clinical failures when P. knowlesi is treated with mefloquine, the data suggest that caution is required if using mefloquine in prevention or treatment of P. knowlesi infections, until further studies are undertaken.

Medical Treatment: 

CRIMALDDI: platform technologies and novel anti-malarial drug targets

November 14, 2013 - 08:15 -- Open Access
Tags: 
Author(s): 
Vial H, Taramelli D, Boulton IC, Ward SA, Doerig C, Chibale K
Reference: 
Malaria Journal 2013, 12 :396 (5 November 2013)
MalariaWorld

The Coordination, Rationalization, and Integration of antiMALarial drug Discovery & Development Initiatives (CRIMALDDI) Consortium, funded by the EU Framework Seven Programme, has attempted, through a series of interactive and facilitated workshops, to develop priorities for research to expedite the discovery of new anti-malarials.

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New Preclinical Antimalarial Drugs Potently Inhibit Hepatitis C Virus Genotype 1b RNA Replication

September 12, 2013 - 05:39 -- Open Access
Tags: 
Author(s): 
Youki Ueda, Midori Takeda, Kyoko Mori, Hiromichi Dansako, Takaji Wakita, Hye-Sook Kim, Akira Sato, Yusuke Wataya, Masanori Ikeda, Nobuyuki Kato
Reference: 
PLoS ONE 8(8): e72519
MalariaWorld

We found that the preclinical antimalarial drugs N-89 and N-251 exhibited very fast and potent anti-HCV activities using cell-based HCV-RNA-replication assay systems. N-89 and N-251 may be useful as a new type of anti-HCV reagents when used singly or in combination with interferon and/or ribavirin.

Medical Treatment: 

NOT Open Access | Synthesis of novel analogs of 2-pyrazoline obtained from [(7-chloroquinolin-4-yl)amino]chalcones and hydrazine as potential antitumor and antimalarial agents

September 12, 2013 - 05:35 -- NOT Open Access
Author(s): 
Braulio Insuasty, Alba Montoya, Diana Becerra, Jairo Quiroga, Rodrigo Abonia, Sara Robledo, Ivan Darío Vélez, Yulieth Upegui, Manuel Nogueras, Justo Cobo
Reference: 
European Journal of Medicinal Chemistry, Volume 67, September 2013, Pages 252–262
MalariaWorld

A new series of N-acetyl and N-formyl-pyrazoline derivatives 6 and 7–8 were synthesized by cyclocondensation reaction of [(7-chloroquinolin-4-yl)amino]chalcones with hydrazine hydrate in acetic acid and hydrazine hydrate in formic acid respectively.

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