The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10148 malaria professionals are enjoying the free benefits of MalariaWorld today

antimalarials

Anti-malarial activity of the root extract of Euphorbia abyssinica (Euphorbiaceae) against Plasmodium berghei infection in mice

August 5, 2019 - 16:29 -- Open Access
Author(s): 
Abrham Belachew Muluye, Ashenafi Genanew Desta, Selamu Kebamo Abate and Gemechu Tiruneh Dano
Reference: 
Malaria Journal 2019 18:261, 30 July 2019

More than 200 medicinal plants including Euphorbia abyssinica are utilized for treatment of malaria in Ethiopian traditional medical practices. However, the safety, efficacy and quality of these medicinal plants are largely unknown. Pharmacological and toxicological investigations of these plants are among the prioritized issues in every country. The aim of this study was, therefore, to evaluate the anti-malarial activity of Euphorbia abyssinica root extract against Plasmodium berghei infection in mice.

Medical Treatment: 

Oral activity of the antimalarial endoperoxide 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol (N-251) against Leishmania donovani complex

April 2, 2019 - 11:48 -- Open Access
Tags: 
Author(s): 
Kofi Dadzie Kwofie, Kai Sato, Shiroh Iwanaga, et al.
Reference: 
PLoS Negl Trop Dis 13(3): e0007235

Visceral leishmaniasis (VL) is a major problem worldwide and causes significant morbidity and mortality.

Medical Treatment: 

Two successful decades of Swiss collaborations to develop new anti-malarials

March 26, 2019 - 15:59 -- Open Access
Tags: 
Author(s): 
Rob Hooft van Huijsduijnen, Timothy Wells, Marcel Tanner and Sergio Wittlin
Reference: 
Malaria Journal 2019 18:94, 22 March 2019

Over the last two decades there has been a renaissance in the pipeline of new drugs targeting malaria, with the launch of new products that help save the lives of children throughout the world.

Medical Treatment: 

Relationship between weight status and anti-malarial drug efficacy and safety in children in Mali

February 19, 2019 - 14:29 -- Open Access
Author(s): 
Moussa Djimde, Hanen Samouda, Abdoulaye A. Djimde, et al.
Reference: 
Malaria Journal 2019 18:40, 18 February 2019

The findings suggest that weight deficiency has no deleterious effect on anti-malarial drug efficacy.

Person: 
Country: 
Medical Treatment: 

Not Open Access | MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice

December 20, 2018 - 03:27 -- NOT Open Access
Author(s): 
Brittany A. Riggle, Sanhita Sinharay, Dima A. Hammoud, et al.
Reference: 
PNAS December 18, 2018 115 (51) E12024-E12033

The deadliest complication of Plasmodium falciparum infection is cerebral malaria (CM), with a case fatality rate of 15 to 25% in African children despite effective antimalarial chemotherapy.

Medical Treatment: 

NOT Open Access | Synthesis, Biological Evaluation, and Molecular Modeling Studies of Chiral Chloroquine Analogues as Antimalarial Agents

November 28, 2018 - 15:58 -- NOT Open Access
Tags: 
Author(s): 
Srinivasarao Kondaparla, Utsab Debnath, Awakash Soni, Vasantha Rao Dola, Manish Sinha, Kumkum Srivastava, Sunil K. Puri and Seturam B. Katti
Reference: 
Antimicrob. Agents Chemother. December 2018 62:e02347-17

In a focused exploration, we designed, synthesized, and biologically evaluated chiral conjugated new chloroquine (CQ) analogues with substituted piperazines as antimalarial agents.

Medical Treatment: 

NOT Open Access | In Silico Investigation of the Decline in Clinical Efficacy of Artemisinin Combination Therapies Due to Increasing Artemisinin and Partner Drug Resistance

November 28, 2018 - 15:41 -- NOT Open Access
Author(s): 
Sophie G. Zaloumis, Pengxing Cao, Julie A. Simpson, et al.
Reference: 
Antimicrob. Agents Chemother. December 2018 62:e01292-18

Antimalarial treatment currently relies on an artemisinin derivative and a longer-acting partner drug.

Medical Treatment: 

Injectable anti-malarials revisited: discovery and development of new agents to protect against malaria

November 6, 2018 - 14:06 -- Open Access
Tags: 
Author(s): 
Fiona Macintyre, Hanu Ramachandruni, Wiweka Kaszubska, et al.
Reference: 
Malaria Journal 2018 17:402, 1 November 2018

Over the last 15 years, the majority of malaria drug discovery and development efforts have focused on new molecules and regimens to treat patients with uncomplicated or severe disease.

Medical Treatment: 

Isolation, characterization, and biological evaluation of a potent anti-malarial drimane sesquiterpene from Warburgia salutaris stem bark

August 15, 2018 - 16:31 -- Open Access
Author(s): 
Zoxolo N. Nyaba, Pretty Murambiwa, Andy R. Opoku, Samson Mukaratirwa, Francis O. Shode and Mthokozisi B. C. Simelane
Reference: 
Malaria Journal 2018 17:296, 15 August 2018

This study proves that Warburgia salutaris contains components (including iso-mukaadial acetate) that exhibit anti-malarial activity and scientifically validates the use of this plant in folk medicine.

Medical Treatment: 

NOT Open Access | Combination of artemisinin-based natural compounds from Artemisia annua L. for the treatment of malaria: Pharmacodynamic and pharmacokinetic studies

July 6, 2018 - 14:27 -- NOT Open Access
Author(s): 
Jing Li, Chao Zhang, Muxin Gong and Manyuan Wang
Reference: 
Phytotherapy Research banner Volume32, Issue7 July 2018 Pages 1415-1420

Currently, the most effective antimalarial is artemisinin, which is extracted from the leaves of medicinal herb Artemisia annua L. (A. annua).

Medical Treatment: 

Pages

Subscribe to RSS - antimalarials