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Short Technical Report: Hemozoin-free Plasmodium falciparum mitochondria for physiological and drug susceptibility studies

October 6, 2010 - 13:25 -- Patrick Sampao
Michael W. Mather, Joanne M. Morrisey, Akhil B. Vaidya
Molecular and Biochemical Parasitology, Volume 174, Issue 2, December 2010, Pages 150-153

We describe here an improved procedure for the isolation of a mitochondrially enriched preparation from the trophozoite stage of erythrocytic Plasmodium falciparum, combining disruption by N2 cavitation and differential centrifugation with magnetic removal of hemozoin-associated material.

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Preview: Hemozoin: Malaria's “Built-In” Adjuvant and TLR9 Agonist

January 28, 2010 - 10:11 -- Kabogo Ndegwa
Hermann Wagner
Cell Host & Microbe, Volume 7, Issue 1, 21 January 2010, Pages 5-6

The “built-in” adjuvant in a whole-microbe vaccine potentially triggers protective immunity. Coban et al. now demonstrate that crude blood stage extract of the malaria parasite Plasmodium falciparum drives parasite-specific immune responses via Hemozoin, a byproduct of heme detoxification, functioning as a TLR9 agonist and, therefore, as a “built-in” adjuvant.

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