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sulphadoxine-pyrimethamine

Open Access | Clinical Study: Efficacy and Tolerability of Malartin and Sulphadoxine-Pyrimethamine Combination against Uncomplicated Falciparum Malaria in Dibanda, Southwest Cameroon

February 29, 2012 - 14:28 -- Patrick Sampao
Author(s): 
Helen Kuokuo Kimbi, Mesame Ntoko, Nelson N. Ntonifor, Emmaculate Lum, Anna L. Njunda and Peter Nde Fon
Reference: 
Journal of Tropical Medicine, Volume 2012 (2012)

MalariaWorldThe aim of this study was to assess the in vivo efficacy and tolerability of a combination of Malartin (an artesunate) and sulphadoxine-pyrimethamine (SP) in the treatment of uncomplicated falciparum malaria in Dibanda, Cameroon.

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Open Access | Prescription practices and availability of artemisinin monotherapy in India: where do we stand?

December 15, 2011 - 14:50 -- Patrick Sampao
Author(s): 
Mishra N, Anvikar AR, Shah NK, Kamal V, Sharma S, Srivastava H, Das M, Pradhan K, Kumar H, Gupta YK, Gupta P, Dash A, Valecha N
Reference: 
Malaria Journal 2011, 10:360 (13 December 2011)

MalariaWorldThis study resulted in notifications to all state drug controllers in India to withdraw the oral artemisinin formulations from the market. In 2010, artesunate + sulphadoxine-pyrimethamine became the universal first-line treatment for confirmed Plasmodium falciparum malaria and was deployed at full scale.

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Open Access | High prevalence of dhfr triple mutant and correlation with high rates of sulphadoxine-pyrimethamine treatment failures in vivo in Gabonese children

May 18, 2011 - 10:13 -- Kabogo Ndegwa
Author(s): 
Ghyslain Mombo-Ngoma, Sunny Oyakhirome, Rosalynn Ord, Julian J Gabor, Katja C Greutelaers, Katharina Profanter, Benedikt Greutelaers, Florian Kurth, Bertrand Lell, Juergen FJ Kun, Saadou Issifou, Cally Roper, Peter G Kremsner, Martin P Grobusch
Reference: 
Malaria Journal 2011, 10:123 (14 May 2011)

There is a high prevalence of dhfr triple mutant with some dhps point mutations in Gabon, in line with treatment failures observed, and molecular markers of SP resistance should be closely monitored.

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Open Access | Therapeutics: Intermittent preventive treatment of infants with mefloquine reduces risk of clinical malaria in areas of moderate malaria transmission and high resistance to sulphadoxine-pyrimethamine

June 8, 2010 - 09:48 -- Kabogo Ndegwa
Author(s): 
R McGready
Reference: 
Evid Based Med (2010) 15: 71-2

Commentary on:

Gosling RD, Gesase S, Mosha JF, et al . Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial. Lancet 2009;374:1521–32.

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Open Access | Efficacy of amodiaquine, sulphadoxine-pyrimethamine and their combination for the treatment of uncomplicated Plasmodium falciparum malaria in children in Cameroon at the time of policy change to artemisinin-based combination therapy

January 29, 2010 - 15:07 -- Ingeborg van Schayk
Author(s): 
Wilfred F Mbacham, Marie-Solange B Evehe, Palmer M Netongo, Isabel A Ateh, Patrice N Mimche, Anthony Ajua, Akindeh M Nji, Justin B Echouffo-Tcheugui, Bantar Tawe, Rachel Hallett, Cally Roper, Geoffrey Targett, Brian Greenwood
Reference: 
Malaria Journal 2010, 9:34 (27 January 2010)

Conducted in 2004-2006, the results of this study give updated information about anti-malarials efficacy at the time of policy change to ACT treatment (AQ used in combination with artesunate and SP used in IPT for pregnant women.

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Open Access | Molecular markers of resistance to sulphadoxine-pyrimethamine one year after implementation of intermittent preventive treatment of malaria in infants in Mali

January 13, 2010 - 13:20 -- Ingeborg van Schayk
Author(s): 
Alassane Dicko, Issaka Sagara, Abdoulaye A Djimde, Sidy O Toure, Mariam Traore, Souleymane Dama, Abdoulbaki I Diallo, Amadou Barry, Mohamed Dicko, Oumar M Coulibaly, Christophe Rogier, Alexandra de Sousa, Ogobara K Doumbo
Reference: 
Malaria Journal 2010, 9:9 (10 January 2010)

A paper that addresses the issue of possible selection of drug resistant parasites in the context of Intermittent Preventive Treatment in infants. Importantly, this study evaluates the impact of the intervention at community level, in a context of a large scale implementation.

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