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Artemisinin

K13-propeller gene polymorphisms of Plasmodium falciparum and the therapeutic effect of artesunate among migrant workers returning to Guangxi, China (2014–2017)

October 22, 2019 - 16:36 -- Open Access
Author(s): 
Jun Li, Yunliang Shi, Jian Qin, et al.
Reference: 
Malaria Journal 2019 18:349, 16 October 2019

The resistance of Plasmodium falciparum to artemisinin has been identified in Asia and some parts of Africa. The drug resistance of P. falciparum will be an obstacle to the successful elimination of malaria by 2025. Whole-genome sequencing of the artemisinin-resistant parasite line revealed mutations on the k13 gene associated with drug resistance in P. falciparum. To understand the artemisinin resistance of the imported P. falciparum cases from Africa, the mutations in the k13 gene in parasites from imported malaria cases in Guangxi Province were detected and the treatment efficiency of artesunate monotherapy was observed.

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Upon entering an age of global ivermectin-based integrated mass drug administration for neglected tropical diseases and malaria

May 3, 2017 - 08:46 -- Open Access
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Author(s): 
Frank O. Richards
Reference: 
Malaria Journal 2017 16:168, 24 April 2017

Ivermectin mass drug administration (MDA) in humans to reduce malaria vectors is yet another use for this remarkable medicine whose discoverers shared the 2015 Nobel Prize in Medicine with the discoverer of artemisinin.

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The production and exportation of artemisinin-derived drugs in China: current status and existing challenges

July 19, 2016 - 16:27 -- Open Access
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Author(s): 
Yangmu Huang, Hui Li, Danlu Peng, Yu Wang, Qiaomeng Ren and Yan Guo
Reference: 
Malaria Journal 2016 15:365, 15 July 2016

Exports of artemisinin derivatives for China have been transforming from API-dominated to FPP-dominated.

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Declining malaria, rising of dengue and Zika virus: insights for mosquito vector control

May 3, 2016 - 15:18 -- Open Access
Author(s): 
Giovanni Benelli & Heinz Mehlhorn
Reference: 
Parasitology Research, May 2016, Volume 115, Issue 5, pp 1747-1754

The fight against mosquito-borne diseases is a challenge of huge public health importance.

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Distribution of Plasmodium vivax pvdhfr and pvdhps alleles and their association with sulfadoxine–pyrimethamine treatment outcomes in Indonesia

September 23, 2015 - 16:56 -- Open Access
Author(s): 
Puji Asih, Sylvia Marantina, Din Syafruddin, et al.
Reference: 
Malaria Journal 2015, 14:365 (22 September 2015)

With proper malaria diagnosis, SP may still be used as a rational anti-malarial drug either as a single prescription or in combination with artemisinin.

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Imputation-Based Population Genetics Analysis of Plasmodium falciparum Malaria Parasites

May 4, 2015 - 10:40 -- Open Access
Author(s): 
Hanif Samad, Francesc Coll, Mark D. Preston, Harold Ocholla, Rick M. Fairhurst, Taane G. Clark
Reference: 
PLoS Genet 11(4): e1005131

Whole-genome sequencing technologies are being increasingly applied to Plasmodium falciparum clinical isolates to identify genetic determinants of malaria pathogenesis.

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NOT Open Access | Mastering malaria: What helps and what hurts

March 11, 2015 - 16:14 -- NOT Open Access
Author(s): 
Sunetra Gupta
Reference: 
PNAS March 10, 2015 vol. 112 no. 10 2925-2926

Paul Russell’s Man’s Mastery of Malaria (1), written in 1955, opens with these wistful words: “While keeping in mind the realities, one can nevertheless be confident that malaria is well on its way toward oblivion

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Ethics, Economics, and the Use of Primaquine to Reduce Falciparum Malaria Transmission in Asymptomatic Populations

August 25, 2014 - 09:53 -- Open Access
Author(s): 
Yoel Lubell, Lisa White, Sheila Varadan, Tom Drake, Shunmay Yeung, Phaik Yeong Cheah, Richard J. Maude, Arjen Dondorp, Nicholas P. J. Day, Nicholas J. White, Michael Parker
Reference: 
PLoS Med 11(8): e1001704

Following a decade of gains in malaria control, two divergent prospects are emerging:

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NOT Open Access | A review of dihydroartemisinin as another gift from traditional Chinese medicine not only for malaria control but also for schistosomiasis control

May 6, 2014 - 08:10 -- NOT Open Access
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Author(s): 
Xu-Guang Zhang , Gui-Xin Li , Shu-Shun Zhao , Fu-Liang Xu , Yun-Hai Wang & Wei Wang
Reference: 
Parasitology Research May 2014, Volume 113, Issue 5, pp 1769-1773

Artemisinin, also known as qinghaosu, is a sesquiterpene lactone endoperoxide extracted from the plant Artemisia annua L, an herb employed in traditional Chinese medicine.

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Early parasitological response following artemisinin-containing regimens: a critical review of the literature

April 22, 2013 - 12:29 -- Open Access
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Author(s): 
Das D, Price RN, Bethell D, Guerin PJ, Stepniewska K
Reference: 
Malaria Journal 2013, 12:125 (19 April 2013)
MalariaWorld

These results highlight the normal distribution of early parasitological responses following ACT, and the influence that heterogeneity in study design, host and parasite factors have in confounding a surveillance system based on Day 3 parasite positivity.

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