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antimalarial drugs

Mangrove plants as a source of lead compounds for the development of new antiplasmodial drugs from South East coast of India

May 25, 2011 - 08:13 -- Kabogo Ndegwa
Author(s): 
Sundaram Ravikumar, Samuel Jacob Inbaneson, Palavesam Suganthi, Malaiyandi Venkatesan and Andy Ramu
Reference: 
Parasitology Research, Volume 108, Number 6, 1405-1410

Malaria is the world’s leading killer among the infectious diseases. The treatment of malaria is mystified by the challenges of widespread resistance of the malaria parasites to cheap and affordable antimalarial drugs.

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Open Access | Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

March 17, 2011 - 08:13 -- Kabogo Ndegwa
Author(s): 
Susan A. Charman, Sarah Arbe-Barnes, Jonathan L. Vennerstrom, et al.
Reference: 
PNAS March 15, 2011 vol. 108 no. 11 4400-4405

Ozonide OZ439 is a synthetic peroxide antimalarial drug candidate designed to provide a single-dose oral cure in humans.

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Minireview: Investigation of some medicinal plants traditionally used for treatment of malaria in Kenya as potential sources of antimalarial drugs

February 24, 2011 - 07:39 -- Kabogo Ndegwa
Author(s): 
C.N. Muthaura, J.M. Keriko, S. Derese, A. Yenesew, G.M. Rukunga
Reference: 
Experimental Parasitology, Volume 127, Issue 3, March 2011, Pages 609-626

Malaria is a major public health problem in many tropical and subtropical countries and the burden of this disease is getting worse, mainly due to the increasing resistance of Plasmodium falciparum against the widely available antimalarial drugs.

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Open Access | Improving Rational Treatment of Malaria: Perceptions and Influence of RDTs on Prescribing Behaviour of Health Workers in Southeast Nigeria

February 7, 2011 - 08:08 -- Kabogo Ndegwa
Author(s): 
Benjamin S. C. Uzochukwu, Emmanuel Onwujekwe, Nkoli N. Ezuma, Ogochukwu P. Ezeoke, Miriam O. Ajuba, Florence T. Sibeudu
Reference: 
PLoS ONE 6(1): e14627

RDT-supported malaria diagnosis may have led to the overprescription of ACTs, with the drug being prescribed to people with RDT-negative results.

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Open Access | A Research Agenda for Malaria Eradication: Drugs

January 27, 2011 - 09:50 -- Kabogo Ndegwa
Author(s): 
The malERA Consultative Group on Drugs
Reference: 
PLoS Med 8(1): e1000402

Antimalarial drugs will be essential tools at all stages of malaria elimination along the path towards eradication, including the early control or “attack” phase to drive down transmission and the later stages of maintaining interruption of transmission, preventing reintroduction of malaria, and eliminating the last residual foci of infection.

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Population Pharmacokinetics of Sulfadoxine and Pyrimethamine in Malawian Children With Malaria

January 25, 2011 - 09:21 -- Kabogo Ndegwa
Author(s): 
D J Bell, S K Nyirongo, M Mukaka, M E Molyneux, P A Winstanley and S A Ward
Reference: 
Clinical Pharmacology & Therapeutics (2011) 89 2, 268–275

In addition to parasite resistance, inadequate levels of exposure to antimalarial drugs may contribute to treatment failure.

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Molecular Assessment of Plasmodium falciparum Resistance to Antimalarial Drugs in Papua New Guinea Using an Extended Ligase Detection Reaction Fluorescent Microsphere Assay

January 24, 2011 - 11:11 -- Kabogo Ndegwa
Author(s): 
Rina P. M. Wong, Harin Karunajeewa, Ivo Mueller, Peter Siba, Peter A. Zimmerman, and Timothy M. E. Davis
Reference: 
Antimicrobial Agents and Chemotherapy, February 2011, p. 798-805, Vol. 55, No. 2

Surveillance for Plasmodium falciparum drug resistance mutations is becoming an established tool for assessing antimalarial treatment effectiveness.

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Plasmodium yoelii: Correlation of TEP1 with mosquito melanization induced by nitroquine

January 4, 2011 - 06:31 -- Kabogo Ndegwa
Author(s): 
Jian Zhang, Fu Sheng Huang, Wen Yue Xu, Ying Wang, Tao Li Zhou, Jian Hua Duan
Reference: 
Experimental Parasitology, Volume 127, Issue 1, January 2011, Pages 52-57

The antimalarial drug nitroquine is not only an effective antimalarial drug, it is also able to induce the melanization of Plasmodium species.

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Plasmodium falciparum: Solanum nudum SN-1 steroid antiplasmodial activity when combined with antimalarial drugs

January 4, 2011 - 06:25 -- Kabogo Ndegwa
Author(s): 
Adriana Pabón, Eric Deharo, Silvia Blair
Reference: 
Experimental Parasitology, Volume 127, Issue 1, January 2011, Pages 222-227

The effect of 16 alpha-acetoxy-26-hydroxycholest-4-ene-3,22-dione (SN-1) isolated from Solanum nudum Dunal (a Solanaceae traditionally used for treating fever in Colombia) on Plasmodium falciparum erythrocyte stages and its in vitro antiplasmodial activity when combined with the following conventional drugs was studied: chloroquine (CQ), amodiaquine (AQ), desethylamodiaquine (desethyl-AQ), quinine (QN), artemisinin (AR), atovaquone (ATV) and quinine (QN).

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Strain-specific immunity induced by immunization with pre-erythrocytic stages of Plasmodium chabaudi (pages 73–78)

December 16, 2010 - 08:54 -- Kabogo Ndegwa
Author(s): 
R. L. Culleton, M. Inoue, S. E. Reece, S. Cheesman, R. Carter
Reference: 
Parasite Immunology, Volume 33, Issue 1, pages 73–78, January 2011

One of the most promising approaches in the efforts to produce a malaria vaccine involves the use of attenuated whole sporozoite immunizations.

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