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antimalarial drugs

Open Access | Anti-malarial drugs: how effective are they against Plasmodium falciparum gametocytes?

February 9, 2012 - 11:20 -- Kabogo Ndegwa
Author(s): 
Peatey CL, Leroy D, Gardiner DL, Trenholme KR
Reference: 
Malaria Journal 2012, 11:34 (6 February 2012)

MalariaWorldThere is a need to identify new compounds with activity against late stage gametocytes and the information provided by this in vitro assay is a valuable first step, which can guide future clinical studies.

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The antiplasmodial activity of Anogeissus leiocarpus and its effect on oxidative stress and lipid profile in mice infected with Plasmodium bergheii

January 11, 2012 - 08:37 -- Kabogo Ndegwa
Author(s): 
Olusegun Matthew Akanbi, Akhere A. Omonkhua, Christianah M. Cyril-Olutayo & Rotimi Yemi Fasimoye
Reference: 
Parasitology Research, Volume 110, Number 1, 219-226

MalariaWorldMethanolic extracts of Anogeissus leiocarpus has been considered locally to have the same antimalarial activities as artemisinin derivatives.

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In vitro sensitivity of Plasmodium falciparum field isolates to extracts from Cameroonian Annonaceae plants

January 11, 2012 - 08:34 -- Kabogo Ndegwa
Author(s): 
Eugénie Aimée Madiesse Kemgne, Wilfred Fon Mbacham, Fabrice Fekam Boyom, Paul Henri Amvam Zollo, Etienne Tsamo & Philip J. Rosenthal
Reference: 
Parasitology Research, Volume 110, Number 1, 109-117

MalariaWorldAnnonaceae species, Uvariopsis congolana (leaf, stem), Polyalthia oliveri (stem bark), and Enantia chlorantha (stem, stem bark) with yields ranging from 0.33% to 4.60%.

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Antiparasitic drugs: Two-pronged tactics for malaria control

January 4, 2012 - 14:42 -- Kabogo Ndegwa
Author(s): 
Peter Kirkpatrick
Reference: 
Nature Reviews Drug Discovery 11, 24 (January 2012)

MalariaWorldMost existing and investigational drugs for malaria are targeted at the stages of the Plasmodium spp. parasite life cycle in red blood cells, which underlie the disease manifestations.

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Generation of the potent anti-malarial drug artemisinin in tobacco

December 14, 2011 - 08:00 -- Kabogo Ndegwa
Author(s): 
Moran Farhi, Elena Marhevka, Julius Ben-Ari, Anna Algamas-Dimantov, Zhuobin Liang, Vardit Zeevi, Orit Edelbaum, Ben Spitzer-Rimon, Hagai Abeliovich, Betty Schwartz, Tzvi Tzfira and Alexander Vainstein
Reference: 
Nature Biotechnology, Volume: 29,Pages: 1072–1074 Year published:(2011)

MalariaWorldThe emergence of multidrug-resistant strains of Plasmodium spp., the etiological agent of malaria, constitutes a major threat to controlling the disease1, 2.

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Plasmodium falciparum: Effect of antimalarial drugs, malaria pigment (β-haematin) and Plasmodium falciparum lysate on monocyte GTP-cyclohydrolase 1 gene expression

October 19, 2011 - 06:55 -- Kabogo Ndegwa
Author(s): 
Bridgette M. Cumming, Gregory M.F. Watson, J.P. Dean Goldring
Reference: 
Experimental Parasitology, Volume 129, Issue 3, November 2011, Pages 312-317

MalariaWorldIn interferon-γ activated human macrophages, GTP-cyclohydrolase 1 catalyses the conversion of guanosine triphosphate to 7,8-dihydroneopterin triphosphate, which is dephosphorylated and oxidized to form neopterin.

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Open Access | Transgenic Plasmodium parasites stably expressing Plasmodium vivax dihydrofolate reductase-thymidylate synthase as in vitro and in vivo models for antifolate screening

October 11, 2011 - 06:56 -- Kabogo Ndegwa
Author(s): 
Somsak V, Uthaipibull C, Prommana P, Srichairatanakool S, Yuthavong Y, Kamchonwongpaisan S
Reference: 
Malaria Journal 2011, 10:291 (7 October 2011)

MalariaWorldWith the permanent integration of Pvdhfr-ts gene in the genome, the transgenic Plasmodium lines expressing PvDHFR-TS are genetically stable and will be useful for screening anti-P. vivax compounds targeting PvDHFR-TS.

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Effects of Lime Juice on Malaria Parasite Clearance

September 29, 2011 - 08:44 -- Kabogo Ndegwa
Author(s): 
S. A. Adegoke, O. A. Oyelami, O. S. Olatunya and L. A. Adeyemi
Reference: 
Phytotherapy Research, Volume 25, Issue 10, pages 1547–1550, October 2011

MalariaWorldIt may therefore be inferred, from this preliminary work, that lime juice when used with the appropriate antimalarial may enhance malaria parasite clearance especially in those with uncomplicated malaria.

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Open Access | Methodology: The parasite clearance curve

September 29, 2011 - 07:05 -- Kabogo Ndegwa
Author(s): 
N J White
Reference: 
Malaria Journal 2011, 10:278 (22 September 2011)

MalariaWorldParasite clearance rates are important measures of anti-malarial drug efficacy. They are particularly important in the assessment of artemisinin resistance.

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Open Access | The Next Opportunity in Anti-Malaria Drug Discovery: The Liver Stage

September 28, 2011 - 07:01 -- Kabogo Ndegwa
Author(s): 
Emily R. Derbyshire, Maria M. Mota, Jon Clardy
Reference: 
PLoS Pathog 7(9): e1002178

Malaria afflicts 350–500 million people annually, and this debilitating and deadly infectious disease exacts a heavy toll on susceptible populations around the globe.

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