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antimalarial drugs

A lactate dehydrogenase ELISA-based assay for the in vitro determination of Plasmodium berghei sensitivity to anti-malarial drugs

November 12, 2012 - 08:55 -- Open Access
Author(s): 
Orjuela-Sánchez P, Duggan E, Nolan J, Frangos JA, Carvalho LJ
Reference: 
Malaria Journal 2012, 11:366 (5 November 2012)
MalariaWorld

This ELISA-based in vitro drug assay is easy to implement, fast, and avoids the use radioisotopes or expensive equipment.

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An Analytical Method for Assessing Stage-Specific Drug Activity in Plasmodium vivax Malaria: Implications for Ex Vivo Drug Susceptibility Testing

August 15, 2012 - 07:30 -- Kabogo Ndegwa
Author(s): 
Douglas H. Kerlin, Kane Boyce, Jutta Marfurt, Julie A. Simpson, Enny Kenangalem, Qin Cheng, Ric N. Price, Michelle L. Gatton
Reference: 
PLoS Negl Trop Dis 6(8): e1772

MalariaWorldThe emergence of highly chloroquine (CQ) resistant P. vivax in Southeast Asia has created an urgent need for an improved understanding of the mechanisms of drug resistance in these parasites, the development of robust tools for defining the spread of resistance, and the discovery of new antimalarial agents.

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NOT Open Access | New frontiers in ethnomedicine: exploring the Angolan indigenous pharmacopeia for novel antimalarial drugs

July 5, 2012 - 14:37 -- Kabogo Ndegwa
Author(s): 
Walter Rangel Campos, Pedro Pina Catarino, Heinrich C. Hoppe
Reference: 
Drug Discovery Today, Volume 17, Issues 13–14, July 2012, Pages 651–653

No abstract available

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Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria

May 24, 2012 - 08:59 -- Kabogo Ndegwa
Author(s): 
Giancarlo A. Biagini, Nicholas Fisher, Stephen A. Ward, et al.
Reference: 
PNAS May 22, 2012 vol. 109 no. 21 8298-8303

MalariaWorldThere is an urgent need for new antimalarial drugs with novel mechanisms of action to deliver effective control and eradication programs.

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NOT Open Access | Rapid, Field-Deployable Method for Genotyping and Discovery of Single-Nucleotide Polymorphisms Associated with Drug Resistance in Plasmodium falciparum

May 16, 2012 - 06:48 -- Kabogo Ndegwa
Author(s): 
Rachel Daniels, Daouda Ndiaye, Mikeal Wall, Jason McKinney, Papa Diogoye Séne, Pardis C. Sabeti, Sarah K. Volkman, Souleymane Mboup, and Dyann F. Wirth
Reference: 
Antimicrob. Agents Chemother. June 2012 vol. 56 no. 6 2976-2986

MalariaWorldDespite efforts to reduce malaria morbidity and mortality, drug-resistant parasites continue to evade control strategies.

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Open Access | Activity of Clinically Relevant Antimalarial Drugs on Plasmodium falciparum Mature Gametocytes in an ATP Bioluminescence “Transmission Blocking” Assay

April 26, 2012 - 13:17 -- Kabogo Ndegwa
Author(s): 
Joël Lelièvre, Maria Jesus Almela, Sonia Lozano, Celia Miguel, Virginia Franco, Didier Leroy, Esperanza Herreros
Reference: 
PLoS ONE 7(4): e35019

MalariaWorldThe work described here represents another significant step towards determination of the activity of new molecules on mature gametocytes of any strain with an automated assay suitable for medium/high-throughput screening.

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Review: HIV and malaria interactions: where do we stand?

March 15, 2012 - 06:59 -- Kabogo Ndegwa
Author(s): 
Raquel González, Ricardo Ataíde, Denise Naniche, Clara Menéndez, Alfredo Mayor
Reference: 
Expert Review of Anti-infective Therapy, February 2012, Vol. 10, No. 2, Pages 153-165

MalariaWorldReversing the spread of HIV infection and the incidence of malaria constitute two of the Millenium Development Goals.

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Open Access | Biological activities of nitidine, a potential anti-malarial lead compound

March 14, 2012 - 07:03 -- Kabogo Ndegwa
Author(s): 
Bouquet J, Rivaud M, Chevalley S, Deharo E, Jullian V, Valentin A
Reference: 
Malaria Journal 2012, 11:67 (9 March 2012)

MalariaWorldNitidine can be considered a potential anti-malarial lead compound. Its ability to complex haem and inhibit beta-haematin formation suggests a mechanism of action similar to that of chloroquine.

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Open Access | The Activities of Current Antimalarial Drugs on the Life Cycle Stages of Plasmodium: A Comparative Study with Human and Rodent Parasites

March 7, 2012 - 13:09 -- Kabogo Ndegwa
Author(s): 
Michael Delves, David Plouffe, Christian Scheurer, Stephan Meister, Sergio Wittlin, Elizabeth A. Winzeler, Robert E. Sinden, Didier Leroy
Reference: 
PLoS Med 9(2): e1001169

MalariaWorldThese data enable objective comparisons of the strengths and weaknesses of each chemical class at targeting each stage of the lifecycle.

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Open Access | P. falciparum In Vitro Killing Rates Allow to Discriminate between Different Antimalarial Mode-of-Action

March 6, 2012 - 07:41 -- Kabogo Ndegwa
Author(s): 
Laura M. Sanz, Benigno Crespo, Cristina De-Cózar, Xavier C. Ding, Jose L. Llergo, Jeremy N. Burrows, Jose F. García-Bustos, Francisco-Javier Gamo
Reference: 
PLoS ONE 7(2): e30949

MalariaWorldChemotherapy is still the cornerstone for malaria control. Developing drugs against Plasmodium parasites and monitoring their efficacy requires methods to accurately determine the parasite killing rate in response to treatment.

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