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antimalarial drugs

Identifying rapidly parasiticidal anti-malarial drugs using a simple and reliable in vitro parasite viability fast assay

November 10, 2015 - 07:16 -- Open Access
Author(s): 
María Linares, Sara Viera, Benigno Crespo, Virginia Franco, María Gómez-Lorenzo, María Jiménez-Díaz, Íñigo Angulo-Barturen, Laura Sanz, Francisco-Javier Gamo
Reference: 
Malaria Journal 2015, 14:441 (5 November 2015)

The quantification of new infections to determine parasite viability offers important advantages over existing methods, and is amenable to medium–high throughput screening.

Medical Treatment: 

Rural-Urban Differences in Household Treatment-Seeking Behaviour for Suspected Malaria in Children at Bata District, Equatorial Guinea

September 3, 2015 - 05:20 -- Open Access
Tags: 
Author(s): 
Maria Romay-Barja, Inma Jarrin, Agustin Benito, et al.
Reference: 
PLoS ONE 10(8): e0135887

The delays in seeking treatment, the type of malaria therapy received and the cost of treatment are the principal problems found in Bata District.

Medical Treatment: 

Evaluating the Pharmacodynamic Effect of Antimalarial Drugs in Clinical Trials by Quantitative PCR

June 17, 2015 - 13:21 -- Open Access
Tags: 
Author(s): 
Louise Marquart, Mark Baker, Peter O'Rourke, and James S. McCarthy
Reference: 
Antimicrob. Agents Chemother. July 2015 vol. 59 no. 7 4249-4259

The ongoing development of new antimalarial drugs and the increasing use of controlled human malaria infection (CHMI) studies to investigate their activity in early-stage clinical trials require the development of methods to analyze their pharmacodynamic effect.

Medical Treatment: 

Development of cultured Plasmodium falciparum blood-stage malaria cell banks for early phase in vivo clinical trial assessment of anti-malaria drugs and vaccines

April 7, 2015 - 10:05 -- Open Access
Author(s): 
Danielle I Stanisic, Xue Q Liu, Michael F Good, et al.
Reference: 
Malaria Journal 2015, 14:143 (7 April 2015)

The production of cultured P. falciparum blood-stage malaria cell banks represents a suitable approach for the generation of material suitable for CHMI studies.

Medical Treatment: 

Assessing anti-malarial drug effects ex vivo using the haemozoin detection assay

April 1, 2015 - 17:59 -- Open Access
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Author(s): 
Maria Rebelo, Carolina Tempera, José F Fernandes, Martin P Grobusch, Thomas Hänscheid
Reference: 
Malaria Journal 2015, 14:140 (1 April 2015)

Flow cytometric detection of Hz allowed the detection of drug effects in blood samples from malaria patients, without using additional reagents or complex protocols.

Medical Treatment: 

Drying anti-malarial drugs in vitro tests to outsource SYBR green assays

March 2, 2015 - 18:47 -- Open Access
Tags: 
Author(s): 
Karim Traore, Adeline Lavoignat, Guillaume Bonnot, Fatimata Sow, Giuliana C Bess, Marjorie Chavant, Frederick Gay, Ogobara Doumbo, Stephane Picot
Reference: 
Malaria Journal 2015, 14:90 (21 February 2015)

The SYBR green I modified protocol produced reliable results and could be a suitable method for in vitro/ex vivo assays in field.

Medical Treatment: 

NOT Open Access | Complex Polymorphisms in the Plasmodium falciparum Multidrug Resistance Protein 2 Gene and Its Contribution to Antimalarial Response

November 19, 2014 - 15:58 -- NOT Open Access
Author(s): 
Maria Isabel Veiga, Nuno S. Osório, Pedro Eduardo Ferreira, Oscar Franzén, Sabina Dahlstrom, J. Koji Lum, Francois Nosten, and José Pedro Gil
Reference: 
Antimicrob. Agents Chemother. December 2014 vol. 58 no. 12 7390-7397

Plasmodium falciparum has the capacity to escape the actions of essentially all antimalarial drugs.

Medical Treatment: 

NOT Open Access | A Microscale Human Liver Platform that Supports the Hepatic Stages of Plasmodium falciparum and vivax

July 31, 2013 - 09:35 -- NOT Open Access
Author(s): 
Sandra March, Shengyong Ng, Sangeeta N. Bhatia, et al.
Reference: 
Cell Host & Microbe, Volume 14, Issue 1, 104-115, 17
MalariaWorld

The Plasmodium liver stage is an attractive target for the development of antimalarial drugs and vaccines, as it provides an opportunity to interrupt the life cycle of the parasite at a critical early stage.

Medical Treatment: 

Malaria Burden and Artemisinin Resistance in the Mobile and Migrant Population on the Thai–Myanmar Border, 1999–2011: An Observational Study

March 7, 2013 - 07:39 -- Open Access
Author(s): 
Verena I. Carrara, Khin Maung Lwin, François Nosten, et al.
Reference: 
PLoS Med 10(3): e1001398
MalariaWorld

The Shoklo Malaria Research Unit has been working on the Thai–Myanmar border for 25 y providing early diagnosis and treatment (EDT) of malaria.

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NOT Open Access | Dehydroepiandrosterone effect on Plasmodium falciparum and its interaction with antimalarial drugs

January 4, 2013 - 14:23 -- NOT Open Access
Author(s): 
L. Zuluaga, S. Parra, E. Garrido, R. López-Muñoz, J.D. Maya, S. Blair
Reference: 
Experimental Parasitology, Volume 133, Issue 1, January 2013, Pages 114–120
MalariaWorld

Dehydroepiandrosterone (DHEA) inhibits glucose 6-phosphate dehydrogenase (G6PDH) of different species and may potentially decrease intracellular glutathione.

Medical Treatment: 

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