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antimalarial drugs

The Candidate Antimalarial Drug MMV665909 Causes Oxygen-Dependent mRNA Mistranslation and Synergizes with Quinoline-Derived Antimalarials

August 31, 2017 - 17:48 -- Open Access
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Author(s): 
Cindy Vallières and Simon V. Avery
Reference: 
Antimicrob. Agents Chemother. September 2017 61:e00459-17

The data collectively suggest translation fidelity as a novel target of antimalarial action and support MMV665909 as a promising drug candidate.

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NOT Open Access | Efficacy and safety of artemether–lumefantrine for the treatment of uncomplicated falciparum malaria at sentinel sites in Mozambique, 2015

June 20, 2017 - 14:36 -- NOT Open Access
Author(s): 
Crizolgo Salvador, Bernardete Rafael, Sónia Enosse, et al.
Reference: 
Acta Tropica, Volume 171, July 2017, Pages 146–150

The resistance of Plasmodium falciparum to anti-malarial drugs continues to challenge malaria control.

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NOT Open Access | Significant Divergence in Sensitivity to Antimalarial Drugs between Neighboring Plasmodium falciparum Populations along the Eastern Border of Myanmar

January 24, 2017 - 18:19 -- NOT Open Access
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Author(s): 
Weilin Zeng, Yao Bai, Meilian Wang, Zenglei Wang, Shuang Deng, Yonghua Ruan, Shi Feng, Zhaoqing Yang, and Liwang Cui
Reference: 
Antimicrob. Agents Chemother. February 2017 vol. 61 no. 2 e01689-16

Malaria parasites in different areas where malaria is endemic display different levels of resistance to antimalarial drugs as the result of varied drug use histories.

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Profile of molecular mutations in pfdhfr, pfdhps, pfmdr1, and pfcrt genes of Plasmodium falciparum related to resistance to different anti-malarial drugs in the Bata District (Equatorial Guinea)

January 17, 2017 - 15:34 -- Open Access
Author(s): 
Pedro Berzosa, Andrés Esteban-Cantos, Agustín Benito, et al.
Reference: 
Malaria Journal 2017 16:28, 13 January 2017

The high level of mutations detected in P. falciparum genes related to SP resistance could be linked to the unsuccessful withdrawal of SP treatment in this area.

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Linking Murine and Human Plasmodium falciparum Challenge Models in a Translational Path for Antimalarial Drug Development

May 25, 2016 - 17:50 -- Open Access
Author(s): 
James S. McCarthy, Louise Marquart, Jörg J. Möhrle, et al.
Reference: 
Antimicrob. Agents Chemother. June 2016 vol. 60 no. 6 3669-3675

Effective progression of candidate antimalarials is dependent on optimal dosing in clinical studies, which is determined by a sound understanding of pharmacokinetics and pharmacodynamics (PK/PD).

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The diagnostic accuracy of the hand-held Raman spectrometer for the identification of anti-malarial drugs

March 16, 2016 - 17:45 -- Open Access
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Author(s): 
Benjamin J. Visser, Sophia G. de Vries, Emmanuel B. Bache, Janneke Meerveld-Gerrits, Daniëlle Kroon, Jimmy Boersma, Selidji T. Agnandji, Michèle van Vugt and Martin P. Grobusch
Reference: 
Malaria Journal 2016 15:160, 15 March 2016

The handheld RS holds promise as an easy-to-use, quick and field-applicable instrument for the evaluation of quality of anti-malarial drugs, potentially empowering pharmacists, drug inspectors and medical regulatory authorities.

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New molecular settings to support in vivo anti-malarial assays

March 10, 2016 - 17:20 -- Open Access
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Author(s): 
Noemí Bahamontes-Rosa, Ane Rodriguez Alejandre, Vanesa Gomez, Sara Viera, María G. Gomez-Lorenzo, Laura María Sanz-Alonso and Alfonso Mendoza-Losana
Reference: 
Malaria Journal 2016 15:147, 8 March 2016

This is the first study to report the suitability of FTA cards and qPCR assay to quantify parasite load in samples from in vivo efficacy models to support the drug discovery process.

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NOT Open Access | Designing a Pediatric Study for an Antimalarial Drug by Using Information from Adults

March 5, 2016 - 23:52 -- NOT Open Access
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Author(s): 
Caroline Petit, Vincent Jullien, Adeline Samson, Jérémie Guedj, Jean-René Kiechel, Sarah Zohar, and Emmanuelle Comets
Reference: 
Antimicrob. Agents Chemother. March 2016 vol. 60 no. 3 1481-1491

The objectives of this study were to design a pharmacokinetic (PK) study by using information about adults and evaluate the robustness of the recommended design through a case study of mefloquine.

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NOT Open Access | Stearylamine Liposomal Delivery of Monensin in Combination with Free Artemisinin Eliminates Blood Stages of Plasmodium falciparum in Culture and P. berghei Infection in Murine Malaria

March 5, 2016 - 23:47 -- NOT Open Access
Author(s): 
Vinoth Rajendran, Shilpa Rohra, Mohsin Raza, Gulam Mustafa Hasan, Suparna Dutt, and Prahlad C. Ghosh
Reference: 
Antimicrob. Agents Chemother. March 2016 vol. 60 no. 3 1304-1318

The global emergence of drug resistance in malaria is impeding the therapeutic efficacy of existing antimalarial drugs.

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Assessment of Markers of Antimalarial Drug Resistance in Plasmodium falciparum Isolates from Pregnant Women in Lagos, Nigeria

February 8, 2016 - 19:51 -- Open Access
Author(s): 
Chimere Obiora Agomo, Wellington Aghoghovwia Oyibo, Colin Sutherland, Rachael Hallet, Mary Oguike
Reference: 
PLoS ONE 11(1): e0146908

Markers of resistance to chloroquine and pyrimethamine were high, whereas cycloguanil-resistance marker was not present in the studied population.

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