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vaccines

Not Open Access | Review: Malaria vaccines: Focus on adenovirus based vectors

July 18, 2012 - 14:25 -- Patrick Sampao
Author(s): 
Nathaniel J. Schuldt, Andrea Amalfitano
Reference: 
Vaccine, Volume 30, Issue 35, 27 July 2012, Pages 5191-5198

This review will provide an update as to the current advancements in malaria vaccine development, with a focus on the use of adenovirus vectored malaria vaccines.

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Not Open Access | Efficacy of Preerythrocytic and Blood-Stage Malaria Vaccines Can Be Assessed in Small Sporozoite Challenge Trials in Human Volunteers

July 11, 2012 - 14:59 -- Patrick Sampao
Author(s): 
Meta Roestenberg, Sake J. de Vlas, An-Emmie Nieman, Robert W. Sauerwein and Cornelus C. Hermsen
Reference: 
J Infect Dis. (2012) 206 (3): 319-323.

MalariaWorldUsing empirical data, we show that these trials, with small numbers of volunteers, are sufficiently powered to detect protective biological effects induced by preerythrocytic and/or blood-stage candidate vaccines if parasitemia is measured daily by quantitative polymerase chain reaction.

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Special Report: Development of vaccines to prevent malaria in pregnant women: WHO MALVAC meeting report

September 27, 2011 - 07:32 -- Patrick Sampao
Author(s): 
Clara Menéndez, Vasee S Moorthy, Zarifah Reed, Azucena Bardají, Pedro Alonso and Graham V Brown
Reference: 
Expert Review of Vaccines,September 2011, Vol. 10, No. 9, Pages 1271-1280

This report includes brief summaries of what is known, and major knowledge gaps in disease burden estimation, pathogenesis and immunity, and the challenges with current preventive strategies for malaria in pregnancy.

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Opinion: Uses of mosquito-stage transmission-blocking vaccines against Plasmodium falciparum

April 29, 2011 - 10:21 -- Patrick Sampao
Author(s): 
Thomas A. Smith, Nakul Chitnis, Olivier J.T. Briët, Marcel Tanner
Reference: 
Trends in Parasitology, Volume 27, Issue 5, May 2011, Pages 190-196

A quantitative framework is used to explore the potential applications and probable effects of sexual stage or mosquito stage transmission blocking vaccines (TBVs) against malaria.

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Open Access | Oral Presentation: Predicted impact of mosquito-stage transmission-blocking vaccines using an ensemble of microsimulations

November 5, 2010 - 14:46 -- Patrick Sampao
Author(s): 
Aurelio Di Pasquale, Nicolas Maire, Thomas Smith
Reference: 
Malaria Journal 2010, 9(Suppl 2):O11 (20 October 2010)

The outputs of the stochastic individual-based simulations are predictions of the epidemiological impact and comparative cost-effectiveness of conceivable control measures, alone or in combination.

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Microbial Immunity and Vaccines: New Candidate Vaccines against Blood-Stage Plasmodium falciparum Malaria: Prime-Boost Immunization Regimens Incorporating Human and Simian Adenoviral Vectors and Poxviral Vectors Expressing an Optimized Antigen Based on Me

October 22, 2010 - 10:19 -- Patrick Sampao
Author(s): 
Anna L.,C. Epp., et al
Reference: 
Infect. Immun., Nov 2010; 78: 4601 - 4612.

We optimized an antigenic insert comprising the four conserved blocks of MSP-1 fused to tandemly arranged sequences that represent both allelic forms of the dimorphic 42-kDa C-terminal region.

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Open Access | WHO policy development processes for a new vaccine: case study of malaria vaccines

June 25, 2010 - 10:10 -- Kabogo Ndegwa
Author(s): 
Milstien J, Cardenas V, Cheyne J, Brooks A
Reference: 
Malaria Journal 2010, 9:182 (24 June 2010)

Although policy issues may be more complex for future vaccines, the lead-time between the date of product regulatory approval and a recommendation for its use in developing countries is decreasing.

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Differential effects of C3d on the immunogenicity of gene gun vaccines encoding Plasmodium falciparum and Plasmodium berghei MSP142

June 10, 2010 - 08:14 -- Patrick Sampao
Author(s): 
Richard Weiss, Maximilian Gabler, Thomas Jacobs, Tim-Wolf Gilberger, Josef Thalhamer, Sandra Scheiblhofer
Reference: 
Vaccine, Volume 28, Issue 28, 17 June 2010, Pages 4515-4522

In this work, C3d exerted differential effects on humoral immune responses after gene gun immunization of mice with plasmids encoding the malaria blood stage antigen MSP142 depending on the nature of the protein Plasmodium falciparum vs. Plasmodium berghei MSP), the localization of the C3d moiety (C-terminal vs. N-terminal), and the presence of putative N-glycosylation sites.

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Evaluation of the safety and immunogenicity of Plasmodium falciparum apical membrane antigen 1, merozoite surface protein 1 or RTS,S vaccines with adjuvant system AS02A administered alone or concurrently in rhesus monkeys

May 28, 2010 - 14:56 -- Patrick Sampao
Author(s): 
Pichyangkul S., Kum-Arb U., et al.
Reference: 
Vaccine, Volume 28, Issue 2, 11 December 2009, Pages 452-462

The objectives of this study were (i) to determine whether MSP142 and AMA1 vaccines formulated with the AS02A Adjuvant System were safe and immunogenic in the rhesus monkey model; (ii) to investigate whether MSP142 or AMA1 induced immune interference to each other, or to RTS,S, when added singly or in combinations at a single injection site; (iii) in the event of immune interference, to determine if this could be reduced when antigens were administered at separate sites.

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