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drug

Short Communication: Implication of intracellular glutathione and its related enzymes on resistance of malaria parasites to the antimalarial drug arteether

January 21, 2011 - 08:42 -- Patrick Sampao
Author(s): 
Ramesh Chandra, L.M. Tripathi, J.K. Saxena, S.K. Puri
Reference: 
Parasitology International, Volume 60, Issue 1, January 2011, Pages 97-100

In this study, we examined the relationship between the intracellular levels of glutathione (GSH) and antioxidant enzymes and resistance to the artemisinin-based drug arteether in experimentally selected arteether-resistant Plasmodium vinckei.

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Comparing metabolic network models based on genomic and automatically inferred enzyme information from Plasmodium and its human host to define drug targets in silico

December 20, 2010 - 09:48 -- Patrick Sampao
Author(s): 
Segun Fatumo, Kitiporn Plaimas, Ezekiel Adebiyi, Rainer König
Reference: 
Infection, Genetics and Evolution, Volume 11, Issue 1, January 2011, Pages 201-208

Comparing the modeling results with a comprehensive list of known drug targets for P. falciparum, showed that we had the best discovery success with a network model consisting only of enzymes from the parasite alone which coding genes were known.

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Antimalarial drugs: Speeding to a new lead

November 15, 2010 - 11:36 -- Patrick Sampao
Author(s): 
Man Tsuey Tse
Reference: 
Nature Reviews Drug Discovery 9, 842 (November 2010)

A public–private partnership has identified a promising new antimalarial compound that is potently effective against a range of Plasmodium species — including some that are resistant to currently used agents — and possesses the pharmacokinetic properties needed to become a viable drug.

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Chemotherapy, Within-Host Ecology and the Fitness of Drug-Resistant Malaria Parasites.

November 11, 2010 - 07:36 -- Patrick Sampao
Author(s): 
Silvie Huijben,William A. Nelson, Andrew R. Wargo, Derek G. Sim, Damien R. Drew,Andrew F.
Reference: 
Evolution, Volume 64, Issue 10, pages 2952–2968, October 2010

Here, we test the hypothesis that the spread of resistance can be slowed by reducing drug treatment and hence restricting competitive release.

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Open Access | Invited Speaker Presentation: Transporters used by parasites as drug targets: tempting but underexploited

November 3, 2010 - 13:37 -- Patrick Sampao
Author(s): 
Henry Staines
Reference: 
Malaria Journal 2010, 9(Suppl 2):I9 (20 October 2010)

Here are presented recent studies on this potential antimalarial target, utilising the rodent P. berghei model to investigate the physiological importance of D-glucose transport in transmission and liver life cycle stages and to generate an in vivo model for testing inhibitors of PfHT.

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Identification of inhibitors for putative malaria drug targets among novel antimalarial

November 3, 2010 - 12:16 -- Patrick Sampao
Author(s): 
Gregory J., Alberto J., et al
Reference: 
Molecular and Biochemical Parasitology, Volume 175, Issue 1, January 2011, Pages 21-29

We have taken a high-throughput approach toward identifying novel antimalarial chemical inhibitors of prioritized drug targets for Plasmodium falciparum, excluding targets which are inhibited by currently used drugs.

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Short Technical Report: Hemozoin-free Plasmodium falciparum mitochondria for physiological and drug susceptibility studies

October 6, 2010 - 13:25 -- Patrick Sampao
Author(s): 
Michael W. Mather, Joanne M. Morrisey, Akhil B. Vaidya
Reference: 
Molecular and Biochemical Parasitology, Volume 174, Issue 2, December 2010, Pages 150-153

We describe here an improved procedure for the isolation of a mitochondrially enriched preparation from the trophozoite stage of erythrocytic Plasmodium falciparum, combining disruption by N2 cavitation and differential centrifugation with magnetic removal of hemozoin-associated material.

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A Comparison of Methods to Detect and Quantify the Markers of Antimalarial Drug Resistance

September 2, 2010 - 15:04 -- Patrick Sampao
Author(s): 
Ian M. Hastings, Christian Nsanzabana, and Tom A. Smith
Reference: 
Am. J. Trop. Med. Hyg., 83(3), 2010, pp. 489-495

Simple counting dramatically reduced sample size and estimate precision, and we show that analysis of unambiguous samples is biased, leaving maximum likelihood or similar statistical inference as the only practical option.

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Review: Malaria gametocytogenesis

May 21, 2010 - 07:00 -- Patrick Sampao
Author(s): 
David A. Baker
Reference: 
Molecular and Biochemical Parasitology, Volume 172, Issue 2, August 2010, Pages 57-65

Recent transcriptome, proteome and reverse genetic studies have added valuable information to that obtained from traditional studies. However, we still have no answer to the fundamental question regarding sexual development: ‘what triggers gametocytogenesis’?

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Open Access | In vitro and in vivo anti-malarial activity of Boerhavia elegans and Solanum surattense

May 13, 2010 - 14:27 -- Kabogo Ndegwa
Author(s): 
Ramazani A, Zakeri S, Sardari S, Khodakarim N, Djadid N
Reference: 
Malaria Journal 2010, 9:124 (12 May 2010)

Anti-plasmodial activities of extracts of B. elegans and S. surattense are reported for the first time.

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