The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10148 malaria professionals are enjoying the free benefits of MalariaWorld today

immunity

Optimal control analysis of a malaria disease transmission model that includes treatment and vaccination with waning immunity

November 16, 2011 - 08:57 -- Patrick Sampao
Author(s): 
K.O. Okosun, Rachid Ouifki, Nizar Marcus
Reference: 
Biosystems, Volume 106, Issues 2-3, November-December 2011, Pages 136-145

MalariaWorldThe results obtained from the numerical simulations of the model show that a possible vaccination combined with effective treatment regime would reduce the spread of the disease appreciably.

Medical Condition: 
Medical Treatment: 

Superior Antimalarial Immunity after Vaccination with Late Liver Stage-Arresting Genetically Attenuated Parasites

June 18, 2011 - 15:05 -- Kabogo Ndegwa
Author(s): 
Noah S. Butler, Nathan W. Schmidt, Ashley M. Vaughan, Ahmed S. Aly, Stefan H.I. Kappe, John T. Harty
Reference: 
Cell Host & Microbe, Volume 9, Issue 6, 16 June 2011, Pages 451-462

While subunit vaccines have shown partial efficacy in clinical trials, radiation-attenuated sporozoites (RAS) remain the “gold standard” for sterilizing protection against Plasmodium infection in human vaccinees.

Medical Condition: 
Medical Treatment: 

Transgenic Plasmodium that expresses HIV-1 Gag elicits immunity and protects mice against vaccinia virus-gag and malarial parasites

November 23, 2010 - 09:54 -- Patrick Sampao
Author(s): 
Bo Jiang, Li Qin, Yanhua Du, Nanzheng Peng, Ling Chen, Zhiwei Chen, Xiaoping Chen
Reference: 
Vaccine, Volume 28, Issue 50, 23 November 2010, Pages 7915-7922

We demonstrated a novel vaccination strategy that uses a live transgenic protozoan parasite-based bivalent vaccine to immunize mice and confer significant levels of protection against VV-gag and malarial parasite challenges.

Medical Condition: 
Medical Treatment: 

Open Access | Oral Presentation: Complete abrogation of sporozoite-induced sterile immunity by blood stage parasites of homologous and heterologous malaria species

November 8, 2010 - 14:48 -- Patrick Sampao
Author(s): 
Megumi Inoue, Jianxia Tang, Osamu Kaneko, Katsuyuki Yui, Richard Culleton
Reference: 
Malaria Journal 2010, 9(Suppl 2):O19 (20 October 2010)

There are ongoing efforts to develop a vaccine based on this system. Attenuation of sporozoites may be achieved via irradiation, genetic modification, or through the use of drugs targeting the blood stage parasite.

Medical Condition: 
Medical Treatment: 

Microbial Immunity and Vaccines: Allele Specificity of Gamma Interferon Responses to the Carboxyl-Terminal Region of Plasmodium falciparum Merozoite Surface Protein 1 by Kenyan Adults with Naturally Acquired Immunity to Malaria

September 24, 2010 - 13:25 -- Patrick Sampao
Author(s): 
Michele D., Kiprotich C., et al.
Reference: 
Infect. Immun., Oct 2010; 78: 4431 - 4441.

This study demonstrates that immunity against MSP133 after cumulative natural infections consists of low-magnitude and difficult-to-detect IFN responses.

Person: 
Country: 
Medical Condition: 
Medical Treatment: 

Fungal and Parasitic Infections: T Cells but Not NK Cells Are Essential for Cell-Mediated Immunity against Plasmodium chabaudi Malaria

September 24, 2010 - 07:05 -- Patrick Sampao
Author(s): 
William P. Weidanz, GayeLyn LaFleur, Andrew Brown, James M. Burns, Jr., Irene Gramaglia, and Henri C. van der Heyde
Reference: 
Infect. Immun., Oct 2010; 78: 4331 - 4340.

Collectively, these data indicate that the suppression of acute P. chabaudi infection by CMI is T cell dependent, is independent of NK cells, and may be attributed to the deficient IFN response seen early in T-cell-depleted mice.

Medical Condition: 
Medical Treatment: 

Open Access | Extreme CD8 T Cell Requirements for Anti-Malarial Liver-Stage Immunity following Immunization with Radiation Attenuated Sporozoites

August 2, 2010 - 13:26 -- Patrick Sampao
Author(s): 
Nathan W. Schmidt, Noah S. Butler, Vladimir P. Badovinac, John T. Harty
Reference: 
PLoS Pathog 6(7): e1000998

Here, we used surrogate T cell activation markers to identify and track whole-parasite, RAS-vaccine-induced effector and memory CD8 T cell responses. Our data show that the differential susceptibility of RAS-immune inbred mouse strains to Plasmodium berghei or P. yoelii sporozoite challenge does not result from host- or parasite-specific decreases in the CD8 T cell response.

Medical Condition: 

Review: Detecting signatures of balancing selection to identify targets of anti-parasite immunity

June 29, 2010 - 08:33 -- Patrick Sampao
Author(s): 
Gareth D. Weedall, David J. Conway
Reference: 
Trends in Parasitology, Volume 26, Issue 7, July 2010, Pages 363-369

We focus on malaria parasites to illustrate challenges and opportunities for detecting targets of frequency-dependent immune selection to discover new potential vaccine candidates.

Medical Condition: 

Special Focus Review: The role of Plasmodium falciparum variant surface antigens in protective immunity and vaccine development

October 25, 2009 - 16:06 -- Ingeborg van Schayk
Author(s): 
Lars Hviid
Reference: 
Human Vaccines, Volume 6, Issue 1, January 2010

This review summarizes the evidence that VSAs are important targets of NAI, discusses why VSA-based vaccines might be feasible despite the extensive intra- and interclonal variation of VSAs, and how vaccines based on this type of antigens fit into the current global strategy to reduce, eliminate, and eventually eradicate the burden of malaria.

Technology: 
Medical Condition: 
Medical Treatment: 
Subscribe to RSS - immunity