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clinical trial

Special Focus Review: The past decade in malaria synthetic peptide vaccine clinical trials

October 25, 2009 - 15:59 -- Ingeborg van Schayk
Elizabeth Nardin
Human Vaccines, Volume 6, Issue 1, January 2010

Over the past  decade (2000 – 2009),  there have been nine clinical trials of synthetic malaria peptide vaccines designed to target the pre-erythrocytic and erythrocytic stages of the Plasmodium falciparum parasite. The results of these clinical trials, while encouraging, have emphasized the critical roles of immunological assays, in particular functional assays, for the evaluation of potential vaccine candidates.  Additional challenges include the need for potent adjuvants for the development of synthetic peptide vaccines that can effectively target multiple stages of the Plasmodium parasite.

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