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antibody

Hemoglobin S and C Heterozygosity Enhances Neither the Magnitude nor Breadth of Antibody Responses to a Diverse Array of Plasmodium falciparum Antigens

November 1, 2011 - 15:14 -- Patrick Sampao
Author(s): 
Xiaolin Tan, Boubacar Traore, Peter D. Crompton, et al.
Reference: 
J Infect Dis. (2011) 204 (11): 1750-1761.

MalariaWorldThese data do not support the hypothesis that HbAS and HbAC protect against malaria by enhancing P. falciparum–specific antibody responses.

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Antibody Responses and Avidity of Naturally Acquired Anti-Plasmodium vivax Duffy Binding Protein (PvDBP) Antibodies in Individuals from an Area with Unstable Malaria Transmission

June 3, 2011 - 10:11 -- Patrick Sampao
Author(s): 
Sedigheh Zakeri, Laleh Babaeekhou, Akram Abouie Mehrizi, Maryam Abbasi and Navid Dinparast Djadid
Reference: 
Am J Trop Med Hyg 2011 84:944-950

This investigation was designed to evaluate naturally acquired antibodies to two variant forms of PvDBP-II antigen (DBP-I and -VI) in malaria individuals (N = 85; median = 22 years) who were living in hypoendemic areas in Iran.

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Microbial Immunity and Vaccines: Allelic Diversity and Naturally Acquired Allele-Specific Antibody Responses to Plasmodium falciparum Apical Membrane Antigen 1 in Kenya

October 22, 2010 - 12:10 -- Patrick Sampao
Author(s): 
Faith H., Gareth D., et al.
Reference: 
Infect. Immun., Nov 2010; 78: 4625 - 4633.

To assess the impact of allelic diversity on naturally acquired immunity, we first sequenced the ectodomain-encoding region of P. falciparum ama1 from subjects with asymptomatic, mild, and severe malaria and measured allele frequency distributions.

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Poly(I:C) is an effective adjuvant for antibody and multi-functional CD4+ T cell responses to Plasmodium falciparum circumsporozoite protein (CSP) and αDEC-CSP in non human primates

October 11, 2010 - 14:45 -- Patrick Sampao
Author(s): 
Kavita T., Barbara J., et al.
Reference: 
Vaccine, Volume 28, Issue 45, 21 October 2010, Pages 7256-7266

Here to assess these variables, non human primates (NHP) were immunized three times with Plasmodium falciparum (Pf) circumsporozoite protein (CSP) or CSP cloned into MG38, a monoclonal antibody that targets DEC-205 (αDEC-CSP), an endocytic receptor on dendritic cells (DCs).

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Recombinant Liver Stage Antigen-1 (LSA-1) formulated with AS01 or AS02 is safe, elicits high titer antibody and induces IFN-γ/IL-2 CD4+ T cells but does not protect against experimental Plasmodium falciparum infection

July 21, 2010 - 07:09 -- Patrick Sampao
Author(s): 
James F., Michele D., et al.
Reference: 
Vaccine, Volume 28, Issue 31, 12 July 2010, Pages 5135-5144

Although the optimal antigen dose of LSA-NRC may not have been selected for the challenge portion of the protocol, further vaccine development based upon LSA-1 should not be excluded and should include alternative vaccine platforms able to elicit additional effector mechanisms such as CD8+ T cells.

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Human Antibody Response to Anopheles gambiae Saliva: An Immuno-Epidemiological Biomarker to Evaluate the Efficacy of Insecticide-Treated Nets in Malaria Vector Control

July 5, 2010 - 07:07 -- Patrick Sampao
Author(s): 
Papa M., Anne P., et al.
Reference: 
Am J Trop Med Hyg, Jul 2010; 83: 115 - 121.

This study investigates a potential immunological marker, based on human antibody responses to Anopheles saliva, as a new indicator to evaluate the efficacy of insecticide-treated nets (ITNs).

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The IC50 of anti-Pfs25 antibody in membrane-feeding assay varies among species

June 2, 2010 - 12:03 -- Patrick Sampao
Author(s): 
Lediya C., Yimin W., et al.
Reference: 
Vaccine, Volume 28, Issue 27, 17 June 2010, Pages 4423-4429

In this study, we purified Pfs25-specific IgGs to convert antibody titer to μg/mL and determined the amount of antibody required to inhibit 50% of oocyst development (IC50).

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Open Access | Functional Memory B Cells and Long-Lived Plasma Cells Are Generated after a Single Plasmodium chabaudi Infection in Mice

December 23, 2009 - 09:21 -- Ingeborg van Schayk
Author(s): 
Ndungu FM, Cadman ET, Coulcher J, Nduati E, Couper E, et al.
Reference: 
PLoS Pathog 5(12): e1000690

The cellular mechanisms underlying B cell and antibody responses are difficult to study in human infections; therefore, we have investigated the kinetics, duration and characteristics of the Plasmodium-specific memory B cell response in an infection of P. chabaudi in mice.

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