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Mefloquine

Case Reports: pfmdr1 Amplification Associated with Clinical Resistance to Mefloquine in West Africa: Implications for Efficacy of Artemisinin Combination Therapies

October 1, 2010 - 09:36 -- Patrick Sampao
Author(s): 
Benoit W., Xavier I., et al.
Reference: 
J. Clin. Microbiol., Oct 2010; 48: 3797 - 3799.

We describe here a clinical failure in the treatment with mefloquine of acute falciparum malaria contracted in Africa and associated with in vitro mefloquine resistance and pfmdr1 copy number amplification.

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Erratum: New Fixed-Dose Artesunate-Mefloquine Formulation against Multidrug-Resistant Plasmodium falciparumin Adults: a Comparative Phase IIb Safety and Pharmacokinetic Study with Standard-Dose Nonfixed Artesunate plus Mefloquine

September 21, 2010 - 08:47 -- Kabogo Ndegwa
Author(s): 
S. Krudsood, S. Looareesuwan, N. Tangpukdee, P. Wilairatana, W. Phumratanaprapin, W. Leowattana, K. Chalermrut, S. Ramanathan, V. Navaratnam, P. Olliaro, M. Vaillant, J. R. Kiechel, and W. R. J. Taylor
Reference: 
Antimicrobial Agents and Chemotherapy, October 2010, p. 4526, Vol. 54, No. 10

Giemsa-stained thick and thin blood films were examined at baseline; every 6 hours for the first 3 days;

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Absence of Association between Piperaquine In Vitro Responses and Polymorphisms in the pfcrt, pfmdr1, pfmrp, and pfnhe Genes in Plasmodium falciparum

August 18, 2010 - 12:43 -- Kabogo Ndegwa
Author(s): 
Sébastien Briolant, Maud Henry, Claude Oeuvray, Rémy Amalvict, Eric Baret, Eric Didillon, Christophe Rogier, and Bruno Pradines
Reference: 
Antimicrobial Agents and Chemotherapy, September 2010, p. 3537-3544, Vol. 54, No. 9

We have analyzed the profiles of 23 of Plasmodium falciparum strains for their in vitro chemosusceptibilities to piperaquine (PPQ), dihydroartemisinin (DHA), chloroquine, monodesethylamodiaquine, quinine, mefloquine, lumefantrine, atovaquone, pyrimethamine, and doxycycline (DOX) in association with polymorphisms in genes involved in quinoline resistance (Plasmodium falciparum crt [pfcrt], pfmdr1, pfmrp, and pfnhe).

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Synergy of mefloquine activity with atorvastatin, but not chloroquine and monodesethylamodiaquine, and association with the pfmdr1 gene

June 10, 2010 - 12:48 -- Patrick Sampao
Author(s): 
Nathalie W., Sébastien B., et al.
Reference: 
J. Antimicrob. Chemother., July 2010; 65: 1387 - 1394.

The aim of the study was to assess the in vitro potentiating effects of atorvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, in combination with mefloquine, chloroquine or monodesethylamodiaquine against Plasmodium falciparum and to evaluate whether the effects of atorvastatin could be associated with mutations or gene copy number in multidrug resistance (MDR)-like protein genes.

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Tolerability and efficacy of a pediatric granule formulation of artesunate-mefloquine in young children from cameroon with uncomplicated falciparum malaria

June 9, 2010 - 08:06 -- Kabogo Ndegwa
Author(s): 
F Tietche, D Chelo, NK Mina Ntoto, FM Djoukoue, C Hatz, S Frey, A Frentzel, S Trapp, R Zielonka, EA Mueller
Reference: 
Am. J. Trop. Med. Hyg., 82(6), 2010, pp. 1034-1040

A fixed-dose pediatric formulation of artesunate and mefloquine (Artequin Pediatric) has been developed. In this open, non-comparative study in Cameroonian children with uncomplicated falciparum malaria, the safety and efficacy of this formulation was tested, with a particular emphasis on the risk of neuropsychiatric adverse events (AEs). In total, 220 subjects, weighing between 10 and 20 kg, were enrolled; 213 qualified for analysis.

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Open Access | Therapeutics: Intermittent preventive treatment of infants with mefloquine reduces risk of clinical malaria in areas of moderate malaria transmission and high resistance to sulphadoxine-pyrimethamine

June 8, 2010 - 09:48 -- Kabogo Ndegwa
Author(s): 
R McGready
Reference: 
Evid Based Med (2010) 15: 71-2

Commentary on:

Gosling RD, Gesase S, Mosha JF, et al . Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial. Lancet 2009;374:1521–32.

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Systematic review: Low-quality evidence that atovaquone-proguanil and doxycycline are better tolerated prophylactic antimalarial regimens in travellers than mefloquine

March 9, 2010 - 13:03 -- Ingeborg van Schayk
Author(s): 
Michael Hawkes
Reference: 
Evid. Based Nurs. 2010; 13:19-20

he scope of this review is the prevention of Plasmodium falciparum, which is the malaria species that causes the overwhelming majority of severe disease and death, and which in many areas of the world is frequently resistant to the classical antimalarial agent chloroquine.

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Clinical Therapeutics: Randomized, Double-Blind Study of the Safety, Tolerability, and Efficacy of Tafenoquine versus Mefloquine for Malaria Prophylaxis in Nonimmune Subjects{triangledown}

January 28, 2010 - 12:14 -- Kabogo Ndegwa
Author(s): 
Peter E. Nasveld, Michael D. Edstein, Mark Reid, Leonard Brennan, Ivor E. Harris, Scott J. Kitchener, Peter A. Leggat, Philip Pickford, Caron Kerr, Colin Ohrt, William Prescott, and the Tafenoquine Study Team
Reference: 
Antimicrobial Agents and Chemotherapy, February 2010, p. 792-798, Vol. 54, No. 2

This study represents the first phase III trial of the safety, tolerability, and effectiveness of tafenoquine for malaria prophylaxis.

Open Access | Effects of mefloquine and artesunate mefloquine on the emergence, clearance and sex ratio of Plasmodium falciparum gametocytes in malarious children

December 23, 2009 - 11:35 -- Ingeborg van Schayk
Author(s): 
Akintunde Sowunmi, Oluchi O Nkogho, Titilope M Okuboyejo, Grace O Gbotosho, Christian T Happi, Elsie O Adewoye
Reference: 
Malaria Journal 2009, 8:297 (16 December 2009)

Addition of artesunate to mefloquine significantly modified the emergence, clearance, and densities of gametocytes and has short-lived, but significant, sex ratio modifying effects in children from this endemic area.

Therapeutic Efficacy and Effects of Artesunate-Mefloquine and Mefloquine Alone on Malaria-Associated Anemia in Children with Uncomplicated Plasmodium falciparum Malaria in Southwest Nigeria

December 18, 2009 - 16:19 -- Ingeborg van Schayk
Tags: 
Author(s): 
Akintunde Sowunmi, Grace O. Gbotosho, Christian Happi, Titilope Okuboyejo, Onikepe Folarin, Sulayman Balogun, AND Obaro Michael
Reference: 
Am J Trop Med Hyg 2009;81 979-986

Both regimens were well tolerated. AMQ clears parasitemia and reduces gametocyte carriage more rapidly and causes lesser fall in hematocrit than MQ, but both regimens are effective treatment of uncomplicated P. falciparum malaria in Nigerian children.

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