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Mefloquine

Population pharmacokinetics of mefloquine, administered as a fixed-dose combination of artesunate-mefloquine in Indian patients for the treatment of acute uncomplicated Plasmodium falciparum malaria

June 9, 2014 - 16:26 -- Open Access
Author(s): 
Jullien V, Valecha N, Srivastava B, Sharma B, Kiechel J
Reference: 
Malaria Journal 2014, 13 :187 (23 May 2014)

The lack of significant covariate explaining the inter-individual variability of mefloquine clearance, combined with the excellent efficacy, supports the use of the standard 200/400 mg of artesunate-mefloquine fixed-dose combination in Indian patients with uncomplicated P. falciparum malaria.

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Gender-specific distribution of mefloquine in the blood following the administration of therapeutic doses

December 16, 2013 - 12:39 -- Open Access
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Author(s): 
Wernsdorfer WH, Noedl H, Rendi-Wagner P, Kollaritsch H, Wiedermann G, Mikolasek A, Karbwang J, Na-Bangchang K
Reference: 
Malaria Journal 2013, 12 :443 (9 December 2013)

Although plasma mefloquine concentrations in female healthy volunteers are considerably higher and the concentrations of the RBCs are initially lower compared to males, they do not seem to justify an adjustment of treatment guidelines for mefloquine in female Caucasian individuals.

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NOT Open Access | Mass administration of the antimalarial drug mefloquine to Guantánamo detainees: a critical analysis

September 18, 2012 - 06:54 -- Kabogo Ndegwa
Author(s): 
Remington L. Nevin
Reference: 
Tropical Medicine & International Health, Volume 17, Issue 10, pages 1281–1288, October 2012

MalariaWorldRecently, evidence has emerged from an unusual form of mass drug administration practised among detainees held at US Naval Station Guantánamo Bay, Cuba (‘Guantánamo’), ostensibly as a public health measure.

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In Vitro Sensitivity of Plasmodium falciparum from China-Myanmar Border Area to Major ACT Drugs and Polymorphisms in Potential Target Genes

June 14, 2012 - 07:59 -- Kabogo Ndegwa
Author(s): 
Zenglei Wang, Daniel Parker, Zhaoqing Yang, et al.
Reference: 
PLoS ONE 7(5): e30927

MalariaWorldDrug resistance has always been one of the most important impediments to global malaria control.

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Restricted | Synthesis, biological evaluation and mechanistic studies of totarol amino alcohol derivatives as potential antimalarial agents

May 8, 2012 - 13:48 -- Kabogo Ndegwa
Author(s): 
Claire Tacon, Eric M. Guantai, Peter J. Smith, Kelly Chibale
Reference: 
Bioorganic & Medicinal Chemistry, Volume 20, Issue 2, 15 January 2012, Pages 893–902

MalariaWorldHerein we report on the semisynthesis and biological evaluation of β-amino alcohol derivatives of the natural product totarol and other simple aromatic systems.

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Open Access | Atorvastatin treatment is effective when used in combination with mefloquine in an experimental cerebral malaria murine model

January 12, 2012 - 07:52 -- Kabogo Ndegwa
Author(s): 
Souraud J, Briolant S, Dormoi J, Mosnier J, Savini H, Baret E, Amalvict R, Soulard R, Rogier C, Pradines B
Reference: 
Malaria Journal 2012, 11:13 (10 January 2012)

MalariaWorldThe combination of AVA and MQ therapy led to a significant delay in mouse mortality.

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Synthesis and antimalarial activity of thioetherhydroxyethylsulfonamides, potential aspartyl protease inhibitors, Part 3

October 26, 2011 - 06:54 -- Kabogo Ndegwa
Author(s): 
Walcimar T. Vellasco Junior, Guilherme P. Guedes, Thatyana R.A. Vasconcelos, Maria G.F. Vaz, Marcus V.N. de Souza, Antoniana U. Krettli, Luisa G. Krettli, Anna Caroline C. Aguiar, Claudia R.B. Gomes, Wilson Cunico
Reference: 
European Journal of Medicinal Chemistry, Volume 46, Issue 11, November 2011, Pages 5688-5693

MalariaWorldA series of novel thioetherhydroxyethylsulfonamide derivatives has been synthesized from the coupling of intermediates 3-amino-4-phenyl-1-thioetherazine-butan-2-oles 6,7 with arenesulfonyl chlorides in good yields.

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Open Access | Use of mefloquine in children - a review of dosage, pharmacokinetics and tolerability data

October 11, 2011 - 06:51 -- Kabogo Ndegwa
Author(s): 
Schlagenhauf P, Adamcova M, Regep L, Schaerer MT, Bansod S, Rhein H
Reference: 
Malaria Journal 2011, 10:292 (7 October 2011)

MalariaWorldCurrently available data provide a scientific basis for the use of mefloquine in small children in the chemoprophylaxis setting and as a part of treatment regimens in children living in endemic areas.

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Genomewide Scan Reveals Amplification of mdr1 as a Common Denominator of Resistance to Mefloquine, Lumefantrine, and Artemisinin in Plasmodium chabaudi Malaria Parasites

September 21, 2011 - 06:27 -- Kabogo Ndegwa
Author(s): 
Sofia Borges, Pedro Cravo, Alison Creasey, Richard Fawcett, Katarzyna Modrzynska, Louise Rodrigues, Axel Martinelli, and Paul Hunt
Reference: 
Antimicrobial Agents and Chemotherapy, October 2011,p. 4858-4865, Vol. 55, No. 10

Multidrug-resistant Plasmodium falciparum malaria parasites pose a threat to effective drug control, even to artemisinin-based combination therapies (ACTs).

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Efficacy and Effectiveness of Mefloquine and Artesunate Combination Therapy for Uncomplicated Plasmodium falciparum Malaria in the Peruvian Amazon

September 8, 2011 - 07:53 -- Patrick Sampao
Author(s): 
Alexandre Macedo de Oliveira, Jorge Chavez, Gabriel Ponce de Leon, Salomon Durand, Nancy Arrospide, Jacquelin Roberts, Cesar Cabezas and Wilmer Marquiño
Reference: 
Am J Trop Med Hyg 2011 vol. 85 no. 3 573-578

Our study shows that MQ + AS is highly efficacious in the Peruvian Amazon.

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