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artemisinin-based combination therapy

Barriers to community case management of malaria in Saraya, Senegal: training, and supply-chains

March 19, 2013 - 09:06 -- Open Access
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Author(s): 
Blanas DA, Ndiaye Y, Nichols K, Jensen A, Siddiqui A, Hennig N
Reference: 
Malaria Journal 2013, 12:95 (14 March 2013)
MalariaWorld

This study identified barriers to implementation of the community case management of malaria programme in Saraya that include lay health worker training, low numbers of women participants, and generalized stock-outs.

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Malaria in infants aged less than six months - is it an area of unmet medical need?

December 4, 2012 - 07:56 -- Open Access
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Author(s): 
D'Alessandro U, Ubben D, Hamed K, Ceesay SJ, Okebe J, Taal M, Lama EK, Keita M, Koivogui L, Nahum A, Bojang K, Sonko AA, Lalya HF, Brabin B
Reference: 
Malaria Journal 2012, 11:400 (2 December 2012)
MalariaWorld

Despite the protection provided by several factors, including maternal antibodies, the burden of malaria in young infants may be higher than previously thought.

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NOT Open Access | Various pfcrt and pfmdr1 Genotypes of Plasmodium falciparum Cocirculate with P. malariae, P. ovale spp., and P. vivax in Northern Angola

September 13, 2012 - 12:35 -- Kabogo Ndegwa
Author(s): 
Cláudia Fançony, Dina Gamboa, Yuri Sebastião, Rachel Hallett, Colin Sutherland, José Carlos Sousa-Figueiredo, and Susana Vaz Nery
Reference: 
Antimicrob. Agents Chemother. October 2012 vol. 56 no. 10 5271-5277

MalariaWorldArtemisinin-based combination therapy for malaria has become widely available across Africa.

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Reductions in Artemisinin-Based Combination Therapy Consumption after the Nationwide Scale up of Routine Malaria Rapid Diagnostic Testing in Zambia

September 7, 2012 - 04:12 -- Patrick Sampao
Author(s): 
Joshua O. Yukich, Adam Bennett, David Bell, et al.
Reference: 
Am J Trop Med Hyg 2012 87:437-446

MalariaWorldData on RDT use, drug consumption, and diagnostic results were collected in three Zambian health districts to determine the impact RDTs had on malaria case management over the period 2004–2009.

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Open Access | Molecular monitoring of Plasmodium falciparum drug susceptibility at the time of the introduction of artemisinin-based combination therapy in Yaounde, Cameroon: Implications for the future

April 13, 2012 - 13:54 -- Patrick Sampao
Author(s): 
Menard S, Morlais I, Tahar R, Sayang C, Issamou Mayengue P, Iriart X, Benoit-Vical F, Lemen B, Magnaval J, Awono-Ambene P, Basco LK, Berry A
Reference: 
Malaria Journal 2012, 11:113 (12 April 2012)

MalariaWorldThis study showed a high prevalence of parasites with mutant pfcrt 76 (83%) and pfmdr1 86 (93%) codons.

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Open Access | Rapid assessment of the performance of malaria control strategies implemented by countries in the Amazon subregion using adequacy criteria: case study

December 21, 2011 - 11:23 -- Kabogo Ndegwa
Author(s): 
Flores W, Chang J, Barillas E
Reference: 
Malaria Journal 2011, 10:379 (20 December 2011)

MalariaWorldAlthough ACT is the strategy with the better implementation in all countries, major gaps exist in implementation of the other three malaria control strategies in terms of technical criteria, coverage and quality desired.

Prevalence of Single Nucleotide Polymorphisms in the Plasmodium falciparum Multidrug Resistance Gene (Pfmdr-1) in Korogwe District in Tanzania Before and After Introduction of Artemisinin-Based Combination Therapy.

December 9, 2011 - 08:34 -- Patrick Sampao
Author(s): 
Thomsen TT, Ishengoma DS, Mmbando BP, Lusingu JP, Vestergaard LS, Theander TG, Lemnge MM, Bygbjerg IC, Alifrangis M.
Reference: 
Am J Trop Med Hyg. 2011 Dec;85(6):979-83.

MalariaWorldThe observed changes may be because of introduction of AL, and if so, this finding gives cause for concern and argues for continued surveillance of these molecular markers.

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Open Access | Using rapid diagnostic tests as source of malaria parasite DNA for molecular analyses in the era of declining malaria prevalence

January 14, 2011 - 06:29 -- Kabogo Ndegwa
Author(s): 
Ishengoma DS, Lwitiho S, Madebe RA, Nyadonde N, Persson O, Vestergaard LS, Bygbjerg IC, Lemnge MM, Alifrangis M
Reference: 
Malaria Journal 2011, 10:6 (12 January 2011)

This study showed that DNA extracted from archived RDTs can be successfully amplified by PCR and used for detection of malaria parasites.

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Open Access | Measuring the efficacy of anti-malarial drugs in vivo: quantitative PCR measurement of parasite clearance

November 16, 2010 - 11:58 -- Kabogo Ndegwa
Author(s): 
Khalid B Beshir, Rachel L Hallett, Alice C Eziefula, Robin Bailey, Julie Watson, Stephen G Wright, Peter L Chiodini, Spencer D Polley, Colin J Sutherland
Reference: 
Malaria Journal 2010, 9:312 (5 November 2010)

Large studies, particularly in Africa where children represent a major proportion of treated cases, will require a simpler blood sample collection regime, and a method capable of high throughput.

Open Access | Editorial: Time for a “Third Wave” of Malaria Activism to Tackle the Drug Stock-out Crisis

December 15, 2009 - 13:53 -- Ingeborg van Schayk
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Author(s): 
The PLoS Medicine Editors
Reference: 
PLoS Med 6(11): e1000188

The PLoS Medicine Editors discuss shortages of artemisinin-based combination therapy in Africa at the point of care and how these can be addressed.

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