This study identified barriers to implementation of the community case management of malaria programme in Saraya that include lay health worker training, low numbers of women participants, and generalized stock-outs.
artemisinin-based combination therapy
Despite the protection provided by several factors, including maternal antibodies, the burden of malaria in young infants may be higher than previously thought.
Artemisinin-based combination therapy for malaria has become widely available across Africa.
Data on RDT use, drug consumption, and diagnostic results were collected in three Zambian health districts to determine the impact RDTs had on malaria case management over the period 2004–2009.
This study showed a high prevalence of parasites with mutant pfcrt 76 (83%) and pfmdr1 86 (93%) codons.
Although ACT is the strategy with the better implementation in all countries, major gaps exist in implementation of the other three malaria control strategies in terms of technical criteria, coverage and quality desired.
The observed changes may be because of introduction of AL, and if so, this finding gives cause for concern and argues for continued surveillance of these molecular markers.
This study showed that DNA extracted from archived RDTs can be successfully amplified by PCR and used for detection of malaria parasites.
Large studies, particularly in Africa where children represent a major proportion of treated cases, will require a simpler blood sample collection regime, and a method capable of high throughput.
The PLoS Medicine Editors discuss shortages of artemisinin-based combination therapy in Africa at the point of care and how these can be addressed.