anti-malarial drugs

Open Access | A progressive declining in the burden of malaria in north-eastern Tanzania

Author(s):

Mmbando BP, Vestergaard LS, Kitua AY, Lemnge MM, Theander TG, Lusingu JP

Reference:

Malaria Journal 2010, 9:216 (23 July 2010)

There has been a marked decline in malaria in the study villages during the past few years. This decline is likely to be due to a combination of factors that include improved access to malaria treatment provided by the trained village helpers, protection from mosquitoes by increased availability of insecticide-impregnated bed nets and a reduced vector density.

Country:

Medical Condition:

Medical Treatment:

Open Access | Progress and challenges to control malaria in a remote area of Chittagong hill tracts, Bangladesh

Author(s):

Haque U, Hashizume M, Sunahara T, Hossain S, Masud Ahmed S, Haque R, Yamamoto T, Glass GE

Reference:

Malaria Journal 2010, 9:156 (10 June 2010)

Closeness to health facilities runs by the malaria control programme and drug vendors were significantly associated with the choice of treatment. A high proportion of people preferred drug vendors without having a proper diagnosis.

Country:

Medical Condition:

Medical Treatment:

Monitoring of in vitro susceptibilities and molecular markers of resistance of Plasmodium falciparum isolates from Thai-Myanmar border to chloroquine, quinine, mefloquine and artesunate

Author(s):

Wanna Chaijaroenkula, Raewadee Wisedpanichkija and Kesara Na-Bangchang

Reference:

Acta Tropica, Volume 113, Issue 2, February 2010, Pages 190-194

The objective of this work was to broaden the insight into the molecular mechanisms of resistance of P. falciparum to quinoline-containing antimalarials and artemisinin derivatives.

Technology:

molecular markers

Medical Condition:

Plasmodium falciparum

resistance

Medical Treatment:

anti-malarial drugs

Open Access | Plasmodium falciparum resistance to anti-malarial drugs in Papua New Guinea: evaluation of a community-based approach for the molecular monitoring of resistance

Author(s):

Jutta Marfurt, Thomas A Smith, Ian M Hastings, Ivo Muller, Albert Sie, Olive Oa, Moses Baisor, John C Reeder, Hans-Peter Beck, Blaise Genton

Reference:

Malaria Journal 2010, 9:8 (7 January 2010)

Interesting paper aiming at investigating the role and applicability of the molecular drug resistance profiles in community samples in Papua New Guinea.

Country:

Papua New Guinea

Medical Condition:

Plasmodium falciparum

resistance

Medical Treatment:

anti-malarial drugs

Open Access | A microarray-based system for the simultaneous analysis of single nucleotide polymorphisms in human genes involved in the metabolism of anti-malarial drugs

Author(s):

Eva-Maria Hodel, Serej D Ley, Weihong Qi, Frederic Ariey, Blaise Genton, Hans-Peter Beck

Reference:

Malaria Journal 2009, 8:285 (9 December 2009)

The major limit of the microarray technology for this purpose was lack of robustness and with a large number of missing data or with incorrect specificity.

Technology:

microarray-based system

pharmacogenetic markers

Medical Treatment:

anti-malarial drugs

Open Access | Methodology: Haemoglobin interference and increased sensitivity of fluorimetric assays for quantification of low-parasitaemia Plasmodium infected erythrocytes

Author(s):

Carlos Moneriz, Patricica Marin-Garcia, Jose M Bautista, Amalia Diez, Antonio Puyet

Reference:

Malaria Journal 2009, 8:279 (4 December 2009)

The use of PG microassays on detergent-free, haemoglobin-depleted samples appears as the best choice both for the detection of Plasmodium in low-density infections and anti-malarial drugs tests.

Technology:

haemoglobin

test

Medical Condition:

Plasmodium

low-density infection

Medical Treatment:

anti-malarial drugs

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