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anti-malarial drugs

Open Access | Prevalence of resistance associated polymorphisms in Plasmodium falciparum field isolates from southern Pakistan

February 2, 2011 - 08:23 -- Kabogo Ndegwa
Author(s): 
Ghanchi NK, Ursing J, Beg MA, Veiga MI, Jafri S, Martensson A
Reference: 
Malaria Journal 2011, 10:18 (28 January 2011)

The results indicate high prevalence of in vivo resistance to chloroquine, whereas high grade resistance to sulphadoxine-pyrimethamine does not appear to be widespread among P. falciparum in southern Pakistan.

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Open Access | Use of the atmospheric generators for capnophilic bacteria Genbag-CO2 for the evaluation of in vitro Plasmodium falciparum susceptibility to standard anti-malarial drugs

January 19, 2011 - 06:34 -- Kabogo Ndegwa
Author(s): 
Pascual A, Basco LK, Baret E, Amalvict R, Travers D, Rogier C, Pradines B
Reference: 
Malaria Journal 2011, 10:8 (14 January 2011)

The atmospheric generators for capnophilic bacteria Genbag CO2(R) is an appropriate technology that can be transferred to the field for epidemiological surveys of drug-resistant malaria.

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Open Access | Cost comparison of microscopy vs empiric treatment for malaria in south-western Nigeria: a prospective study

December 23, 2010 - 14:02 -- Kabogo Ndegwa
Author(s): 
Parikh R, Amole I, Tarpley M, Gbadero D, Davidson M, Vermund SH
Reference: 
Malaria Journal 2010, 9:371 (22 December 2010)

Empiric treatment of all suspected cases of malaria was cheaper (in the end of dry to beginning of rainy season) than only treating those who had microscopy confirmed diagnoses of malaria even though the majority of patients suspected to have malaria were negative via microscopy.

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Open Access | Modulating effects of plasma containing anti-malarial antibodies on in vitro anti-malarial drug susceptibility in Plasmodium falciparum

November 17, 2010 - 08:43 -- Kabogo Ndegwa
Author(s): 
Preeyaporn Monatrakul, Mathirut Mungthin, Arjen M Dondorp, Srivicha Krudsood, Rachanee Udomsangpetch, Polrat Wilairatana, Nicholas J White, Kesinee Chotivanich
Reference: 
Malaria Journal 2010, 9:326 (16 November 2010)

'Immune' plasma containing anti-malarial antibodies inhibits parasite development and multiplication and increases apparent in vitro anti-malarial drug susceptibility of P. falciparum.

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Open Access | Determinants of delay in malaria treatment-seeking behaviour for under-five children in south-west Ethiopia: a case control study

November 16, 2010 - 13:32 -- Kabogo Ndegwa
Author(s): 
Alemayehu Getahun, Kebede Deribe, Amare Deribew
Reference: 
Malaria Journal 2010, 9:320 (11 November 2010)

Effective malaria control programmes should address reducing delayed presentation of children for treatment.

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Open Access | Effects of anti-malarial drugs on the electrocardiographic QT interval modelled in the isolated perfused guinea pig heart system

November 16, 2010 - 13:13 -- Kabogo Ndegwa
Author(s): 
Atsushi Kinoshita, Harumi Yamada, Hajime Kotaki, Mikio Kimura
Reference: 
Malaria Journal 2010, 9:318 (10 November 2010)

In this study, an isolated, perfused guinea pig heart system was constructed to assess the cardiotoxic potential of anti-malarial drugs.

Open Access | Detection of 1014F kdr mutation in four major Anopheline malaria vectors in Indonesia

November 16, 2010 - 12:28 -- Kabogo Ndegwa
Author(s): 
Din Syafruddin, Anggi PN Hidayati, Puji BS Asih, Wiiliam A Hawley, Supratman Sukowati, Neil F Lobo
Reference: 
Malaria Journal 2010, 9:315 (8 November 2010)

The finding documents the presence of this mutant allele in Indonesia, and implies that selection pressure on the Anopheles population in this area has occurred. Further studies to determine the impact of the resistance allele on the efficacy of pyrethroids in control programmes are needed.

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Open Access | Measuring the efficacy of anti-malarial drugs in vivo: quantitative PCR measurement of parasite clearance

November 16, 2010 - 11:58 -- Kabogo Ndegwa
Author(s): 
Khalid B Beshir, Rachel L Hallett, Alice C Eziefula, Robin Bailey, Julie Watson, Stephen G Wright, Peter L Chiodini, Spencer D Polley, Colin J Sutherland
Reference: 
Malaria Journal 2010, 9:312 (5 November 2010)

Large studies, particularly in Africa where children represent a major proportion of treated cases, will require a simpler blood sample collection regime, and a method capable of high throughput.

Open Access | Anti-bacterial activity of intermittent preventive treatment of malaria in pregnancy: comparative in vitro study of sulphadoxine-pyrimethamine, mefloquine, and azithromycin

November 3, 2010 - 08:09 -- Kabogo Ndegwa
Author(s): 
Capan M, Mombo-Ngoma G, Makristathis A, Ramharter M
Reference: 
Malaria Journal 2010, 9:303 (29 October 2010)

These data indicate important differences in the spectrum of anti-bacterial activity for the evaluated anti-malarial drugs.

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Open Access | A progressive declining in the burden of malaria in north-eastern Tanzania

July 27, 2010 - 13:50 -- Kabogo Ndegwa
Author(s): 
Mmbando BP, Vestergaard LS, Kitua AY, Lemnge MM, Theander TG, Lusingu JP
Reference: 
Malaria Journal 2010, 9:216 (23 July 2010)

There has been a marked decline in malaria in the study villages during the past few years. This decline is likely to be due to a combination of factors that include improved access to malaria treatment provided by the trained village helpers, protection from mosquitoes by increased availability of insecticide-impregnated bed nets and a reduced vector density.

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