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anti-malarial drugs

Screening of a library of traditional Chinese medicines to identify anti-malarial compounds and extracts

June 26, 2018 - 16:29 -- Open Access
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Author(s): 
Motohiro Nonaka, Yuho Murata, Ryo Takano, Yongmei Han, Md. Hazzaz Bin Kabir and Kentaro Kato
Reference: 
Malaria Journal 2018 17:244, 25 June 2018

The authors identified four compounds (berberine chloride, coptisine chloride, palmatine chloride, and dehydrocorydaline nitrate) and two extracts (Phellodendri cortex and Coptidis rhizoma) with anti-malarial activity, neither of which had previously been described.

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Modelling the benefits of long-acting or transmission-blocking drugs for reducing Plasmodium falciparum transmission by case management or by mass treatment

August 22, 2017 - 17:51 -- Open Access
Author(s): 
Michael T. Bretscher, Jamie T. Griffin, Azra C. Ghani and Lucy C. Okell
Reference: 
Malaria Journal 2017 16:341, 16 August 2017

These results emphasise the importance of increasing access to treatment for routine case management, and the potential value of choosing first-line anti-malarial treatment policies according to local malaria epidemiology to maximise impact on transmission.

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Glucose-6-phosphate dehydrogenase deficiency in people living in malaria endemic districts of Nepal

May 25, 2017 - 08:47 -- Open Access
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Author(s): 
Prakash Ghimire, Nihal Singh, Leonard Ortega, Komal Raj Rijal, Bipin Adhikari, Garib Das Thakur and Baburam Marasini
Reference: 
Malaria Journal 2017 16:214, 23 May 2017

The higher prevalence of G6PDd in certain ethnic group, gender and geographical region clearly demonstrates clustering of the cases and ascertained the risk groups within the population.

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Antiplasmodial dihetarylthioethers target the coenzyme A synthesis pathway in Plasmodium falciparum erythrocytic stages

May 16, 2017 - 15:02 -- Open Access
Author(s): 
Thomas Weidner, Leonardo Lucantoni, Abed Nasereddin, Lutz Preu, Peter G. Jones, Ron Dzikowski, Vicky M. Avery and Conrad Kunick
Reference: 
Malaria Journal 2017 16:192, 15 May 2017

The class of antiplasmodial bishetarylthioethers reported here has been shown to interfere with plasmodial coenzyme A synthesis, a mechanism of action not yet exploited for registered anti-malarial drugs.

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Working towards consensus on methods used to elicit participant-reported safety data in uncomplicated malaria clinical drug studies: a Delphi technique study

February 8, 2017 - 16:21 -- Open Access
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Author(s): 
Nyaradzo Mandimika, Karen I. Barnes, Clare I. R. Chandler, Cheryl Pace and Elizabeth N. Allen
Reference: 
Malaria Journal 2017 16:52, 28 January 2017

This study succeeded in reaching consensus within a section of the anti-malarial drug clinical research community about using a general question concept, and structured questions for eliciting data about AEs and non-study medication reports.

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Community perceptions of targeted anti-malarial mass drug administrations in two provinces in Vietnam: a quantitative survey

January 10, 2017 - 17:31 -- Open Access
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Author(s): 
Thuy-Nhien Nguyen, Pham N. Huong Thu, Tran Tinh Hien, et al.
Reference: 
Malaria Journal 2017 16:17, 6 January 2017

The study suggests several approaches to increase participation in mass drug administration campaigns.

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Psychiatric effects of malaria and anti-malarial drugs: historical and modern perspectives

June 28, 2016 - 16:34 -- Open Access
Author(s): 
Remington L. Nevin and Ashley M. Croft
Reference: 
Malaria Journal 2016 15:332, 22 June 2016

The modern medical literature implicates malaria, and particularly the potentially fatal form of cerebral malaria, with a risk of neurocognitive impairment.

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Health workers’ compliance to rapid diagnostic tests (RDTs) to guide malaria treatment: a systematic review and meta-analysis

March 16, 2016 - 17:48 -- Open Access
Author(s): 
Alinune N. Kabaghe, Benjamin J. Visser, Rene Spijker, Kamija S. Phiri, Martin P. Grobusch and Michèle van Vugt
Reference: 
Malaria Journal 2016 15:163, 15 March 2016

With regard to published data, compliance to RDT appears to be generally fair in sub-Saharan Africa; compliance to negative results will need to improve to prevent mismanagement of patients and overprescribing of anti-malarial drugs.

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Prioritization of anti-malarial hits from nature: chemo-informatic profiling of natural products with in vitro antiplasmodial activities and currently registered anti-malarial drugs

February 2, 2016 - 19:08 -- Open Access
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Author(s): 
Samuel Ayodele Egieyeh, James Syce, Sarel F. Malan and Alan Christoffels
Reference: 
Malaria Journal 2016 15:50, 29 January 2016

Chemo-informatic profiling of NAA and CRAD have produced a wealth of information that may guide decisions and facilitate anti-malarial drug development from natural products.

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NOT Open Access | Effect of anti-hyperlipidemia drugs on the alpha-tocopherol concentration and their potential for murine malaria infection

January 26, 2016 - 18:55 -- NOT Open Access
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Author(s): 
Aiko Kume, Maria Shirley Herbas, Mototada Shichiri, Noriko Ishida & Hiroshi Suzuki
Reference: 
Parasitology Research, January 2016, Volume 115, Issue 1, pp 69-75

The current preventions of malaria are protection against mosquito bites and taking chemoprophylactic anti-malarial drugs.

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