The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10206 malaria professionals are enjoying the free benefits of MalariaWorld today

anti-malarial drugs

Low polymorphisms in pfact, pfugt and pfcarl genes in African Plasmodium falciparum isolates and absence of association with susceptibility to common anti-malarial drugs

September 2, 2019 - 15:29 -- Open Access
Author(s): 
Francis Tsombeng Foguim, Marie Gladys Robert, Bruno Pradines, et al.
Reference: 
Malaria Journal 2019 18:293, 28 August 2019

Resistance to all available anti-malarial drugs has emerged and spread including artemisinin derivatives and their partner drugs. Several genes involved in artemisinin and partner drugs resistance, such as pfcrt, pfmdr1, pfK13 or pfpm2, have been identified. However, these genes do not properly explain anti-malarial drug resistance, and more particularly clinical failures observed in Africa. Mutations in genes encoding for Plasmodium falciparum proteins, such as P. falciparum Acetyl-CoA transporter (PfACT), P. falciparum UDP-galactose transporter (PfUGT) and P. falciparum cyclic amine resistance locus (PfCARL) have recently been associated to resistance to imidazolopiperazines and other unrelated drugs.

Medical Treatment: 

Screening of a library of traditional Chinese medicines to identify anti-malarial compounds and extracts

June 26, 2018 - 16:29 -- Open Access
Tags: 
Author(s): 
Motohiro Nonaka, Yuho Murata, Ryo Takano, Yongmei Han, Md. Hazzaz Bin Kabir and Kentaro Kato
Reference: 
Malaria Journal 2018 17:244, 25 June 2018

The authors identified four compounds (berberine chloride, coptisine chloride, palmatine chloride, and dehydrocorydaline nitrate) and two extracts (Phellodendri cortex and Coptidis rhizoma) with anti-malarial activity, neither of which had previously been described.

Medical Treatment: 

Modelling the benefits of long-acting or transmission-blocking drugs for reducing Plasmodium falciparum transmission by case management or by mass treatment

August 22, 2017 - 17:51 -- Open Access
Author(s): 
Michael T. Bretscher, Jamie T. Griffin, Azra C. Ghani and Lucy C. Okell
Reference: 
Malaria Journal 2017 16:341, 16 August 2017

These results emphasise the importance of increasing access to treatment for routine case management, and the potential value of choosing first-line anti-malarial treatment policies according to local malaria epidemiology to maximise impact on transmission.

Medical Treatment: 

Glucose-6-phosphate dehydrogenase deficiency in people living in malaria endemic districts of Nepal

May 25, 2017 - 08:47 -- Open Access
Tags: 
Author(s): 
Prakash Ghimire, Nihal Singh, Leonard Ortega, Komal Raj Rijal, Bipin Adhikari, Garib Das Thakur and Baburam Marasini
Reference: 
Malaria Journal 2017 16:214, 23 May 2017

The higher prevalence of G6PDd in certain ethnic group, gender and geographical region clearly demonstrates clustering of the cases and ascertained the risk groups within the population.

Country: 
Medical Treatment: 

Antiplasmodial dihetarylthioethers target the coenzyme A synthesis pathway in Plasmodium falciparum erythrocytic stages

May 16, 2017 - 15:02 -- Open Access
Author(s): 
Thomas Weidner, Leonardo Lucantoni, Abed Nasereddin, Lutz Preu, Peter G. Jones, Ron Dzikowski, Vicky M. Avery and Conrad Kunick
Reference: 
Malaria Journal 2017 16:192, 15 May 2017

The class of antiplasmodial bishetarylthioethers reported here has been shown to interfere with plasmodial coenzyme A synthesis, a mechanism of action not yet exploited for registered anti-malarial drugs.

Medical Treatment: 

Working towards consensus on methods used to elicit participant-reported safety data in uncomplicated malaria clinical drug studies: a Delphi technique study

February 8, 2017 - 16:21 -- Open Access
Tags: 
Author(s): 
Nyaradzo Mandimika, Karen I. Barnes, Clare I. R. Chandler, Cheryl Pace and Elizabeth N. Allen
Reference: 
Malaria Journal 2017 16:52, 28 January 2017

This study succeeded in reaching consensus within a section of the anti-malarial drug clinical research community about using a general question concept, and structured questions for eliciting data about AEs and non-study medication reports.

Medical Treatment: 

Community perceptions of targeted anti-malarial mass drug administrations in two provinces in Vietnam: a quantitative survey

January 10, 2017 - 17:31 -- Open Access
Tags: 
Author(s): 
Thuy-Nhien Nguyen, Pham N. Huong Thu, Tran Tinh Hien, et al.
Reference: 
Malaria Journal 2017 16:17, 6 January 2017

The study suggests several approaches to increase participation in mass drug administration campaigns.

Medical Treatment: 

Psychiatric effects of malaria and anti-malarial drugs: historical and modern perspectives

June 28, 2016 - 16:34 -- Open Access
Author(s): 
Remington L. Nevin and Ashley M. Croft
Reference: 
Malaria Journal 2016 15:332, 22 June 2016

The modern medical literature implicates malaria, and particularly the potentially fatal form of cerebral malaria, with a risk of neurocognitive impairment.

Medical Treatment: 

Health workers’ compliance to rapid diagnostic tests (RDTs) to guide malaria treatment: a systematic review and meta-analysis

March 16, 2016 - 17:48 -- Open Access
Author(s): 
Alinune N. Kabaghe, Benjamin J. Visser, Rene Spijker, Kamija S. Phiri, Martin P. Grobusch and Michèle van Vugt
Reference: 
Malaria Journal 2016 15:163, 15 March 2016

With regard to published data, compliance to RDT appears to be generally fair in sub-Saharan Africa; compliance to negative results will need to improve to prevent mismanagement of patients and overprescribing of anti-malarial drugs.

Medical Treatment: 

Prioritization of anti-malarial hits from nature: chemo-informatic profiling of natural products with in vitro antiplasmodial activities and currently registered anti-malarial drugs

February 2, 2016 - 19:08 -- Open Access
Tags: 
Author(s): 
Samuel Ayodele Egieyeh, James Syce, Sarel F. Malan and Alan Christoffels
Reference: 
Malaria Journal 2016 15:50, 29 January 2016

Chemo-informatic profiling of NAA and CRAD have produced a wealth of information that may guide decisions and facilitate anti-malarial drug development from natural products.

Medical Treatment: 

Pages

Subscribe to RSS - anti-malarial drugs