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dihydroartemisinin-piperaquine (DHA/PQ)

Variable piperaquine exposure significantly impacts protective efficacy of monthly dihydroartemisinin-piperaquine for the prevention of malaria in Ugandan children

September 28, 2015 - 16:48 -- Open Access
Kerstin Sundell, Prasanna Jagannathan, Liusheng Huang, Victor Bigira, James Kapisi, Mary Kakuru, Rada Savic, Moses Kamya, Grant Dorsey, Francesca Aweeka
Malaria Journal 2015, 14:368 (24 September 2015)

The protective efficacy of DHA/PQ chemoprevention in young children was strongly associated with higher drug exposure; in children with the highest PQ exposure, monthly DHA/PQ chemoprevention was nearly 100 % protective against malaria.

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