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artemether–lumefantrine (AL)

Efficacy and safety of artemether–lumefantrine, artesunate–amodiaquine, and dihydroartemisinin–piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in three provinces in Angola, 2017

April 4, 2018 - 15:12 -- Open Access
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Author(s): 
Elizabeth Davlantes, Pedro Rafael Dimbu, Mateusz M. Plucinski, et al.
Reference: 
Malaria Journal 2018 17:144, 3 April 2018

AL, ASAQ, and DP continue to be efficacious against P. falciparum malaria in these provinces of Angola.

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Cost-effectiveness of artemisinin–naphthoquine versus artemether–lumefantrine for the treatment of uncomplicated malaria in Papua New Guinean children

October 31, 2017 - 15:29 -- Open Access
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Author(s): 
Brioni R. Moore, Wendy A. Davis, Philip M. Clarke, Leanne J. Robinson, Moses Laman and Timothy M. E. Davis
Reference: 
Malaria Journal 2017 16:438, 30 October 2017

Whilst AN has superior overall efficacy for the treatment of uncomplicated malaria in PNG children, AL was the less costly regimen.

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The malaria testing and treatment landscape in the southern Lao People’s Democratic Republic (PDR)

May 3, 2017 - 08:50 -- Open Access
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Author(s): 
Saysana Phanalasy
Reference: 
Malaria Journal 2017 16:169, 25 April 2017

Public sector outlets in the southern Lao PDR are typically equipped to test and appropriately treat malaria.

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Reduced ex vivo susceptibility of Plasmodium falciparum after oral artemether–lumefantrine treatment in Mali

February 9, 2017 - 14:52 -- Open Access
Author(s): 
Souleymane Dama, Hamidou Niangaly, Abdoulaye A. Djimde, et al.
Reference: 
Malaria Journal 2017 16:59, 2 February 2017

Malian post-AL P. falciparum isolates were less susceptible to artemether and lumefantrine than baseline isolates.

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Efficacy of text-message reminders on paediatric malaria treatment adherence and their post-treatment return to health facilities in Kenya: a randomized controlled trial

February 6, 2017 - 15:40 -- Open Access
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Author(s): 
Ambrose O. Talisuna, Amos Oburu, Sophie Githinji, Josephine Malinga, Beatrice Amboko, Philip Bejon, Caroline Jones, Robert W. Snow and Dejan Zurovac
Reference: 
Malaria Journal 2017 16:46, 25 January 2017

In this efficacy trial, SMS reminders increased post-treatment return to the health facility, but had no effect on AL adherence which was high in both control and intervention groups.

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In vivo efficacy of artesunate–amodiaquine and artemether–lumefantrine for the treatment of uncomplicated falciparum malaria: an open-randomized, non-inferiority clinical trial in South Kivu, Democratic Republic of Congo

September 6, 2016 - 18:22 -- Open Access
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Author(s): 
Marit de Wit, Anna L. Funk, Teun Bousema, et al.
Reference: 
Malaria Journal 2016 15:455, 6 September 2016

ASAQ is still effective as a treatment for uncomplicated malaria in Baraka, South Kivu, DRC.

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Selection of Plasmodium falciparum pfcrt and pfmdr1 polymorphisms after treatment with artesunate–amodiaquine fixed dose combination or artemether–lumefantrine in Liberia

September 6, 2016 - 18:20 -- Open Access
Author(s): 
Sabina Dahlström Otienoburu, Oumou Maïga-Ascofaré, Sandrine Houzé, et al.
Reference: 
Malaria Journal 2016 15:452, 5 September 2016

Although treatment is highly efficacious, selection of molecular markers in reinfections could indicate a decreased sensitivity or tolerance of parasites to the current treatments and the baseline prevalence of molecular markers should be closely monitored.

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Therapeutic efficacy of artemether–lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Enfranze, north-west Ethiopia

June 24, 2015 - 13:54 -- Open Access
Author(s): 
Gebeyaw Getnet, Abebe Fola, Agersew Alemu, Sisay Getie, Hans-Peter Fuehrer, Harald Noedl
Reference: 
Malaria Journal 2015, 14:258 (24 June 2015)

The relatively high cure rate, low proportion of patients still positive on day 3 as well as parasite clearance times in this study would indicate no imminent threat of artemisinin resistance development in the region.

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