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Open Access | Interaction of Artemisinins with Oxyhemoglobin Hb-FeII, Hb-FeII, CarboxyHb-FeII, Heme-FeII, and Carboxyheme FeII: Significance for Mode of Action and Implications for Therapy of Cerebral Malaria

December 3, 2009 - 12:01 -- Patrick Sampao
Paolo Coghi, Nicoletta Basilico, Donatella Taramelli, Wing-Chi Chan, Richard K. Haynes, Diego Monti
ChemMedChem Volume 4, Issue 12, Date: December 7, 2009, Pages: 2045-2053

The findings not only indicate that artemisinins do not require Hb-FeII or heme-FeII for promotion of antimalarial activity, but are also important in relation to the therapy of severe/complicated or cerebral malaria.

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