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Rapid diagnostic tests (RDT)

Performance of rapid diagnostic test, blood-film microscopy and PCR for the diagnosis of malaria infection among febrile children from Korogwe District, Tanzania

August 1, 2016 - 10:20 -- Open Access
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Author(s): 
Coline Mahende, Billy Ngasala, John Lusingu, Tai-Soon Yong, Paminus Lushino, Martha Lemnge, Bruno Mmbando and Zul Premji
Reference: 
Malaria Journal 2016 15:391, 26 July 2016

Diagnosis of malaria infection is still a challenge due to variation in results among diagnostic methods.

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It could be viral but you don’t know, you have not diagnosed it: health worker challenges in managing non-malaria paediatric fevers in the low transmission area of Mbarara District, Uganda

April 11, 2016 - 16:28 -- Open Access
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Author(s): 
Emily White Johansson, Freddy Eric Kitutu, Chrispus Mayora, Phyllis Awor, Stefan Swartling Peterson, Henry Wamani and Helena Hildenwall
Reference: 
Malaria Journal 2016 15:197, 11 April 2016

Enhanced support is needed to improve RDT adoption at lower level clinics that focuses on empowering providers to successfully manage non-severe, non-malaria paediatric fevers without referral.

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A qualitative study of health professionals’ uptake and perceptions of malaria rapid diagnostic tests in Burkina Faso

April 7, 2016 - 16:58 -- Open Access
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Author(s): 
Sylvie Zongo, Valérie Farquet and Valéry Ridde
Reference: 
Malaria Journal 2016 15:190, 6 April 2016

The use of RDTs points to the co-existence of official standards and different standards applied in practice.

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Reactive case-detection of malaria in Pailin Province, Western Cambodia: lessons from a year-long evaluation in a pre-elimination setting

March 2, 2016 - 17:35 -- Open Access
Author(s): 
John Hustedt, Sara E. Canavati, Arantxa Roca-Feltrer, et al.
Reference: 
Malaria Journal 2016 15:132, 1 March 2016

This study found that RACD identified very few secondary infections when targeting index and neighbouring households for screening.

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Application of magnetic cytosmear for the estimation of Plasmodium falciparum gametocyte density and detection of asexual stages in asymptomatic children

February 26, 2016 - 17:10 -- Open Access
Author(s): 
Deborah Sumari, Brian T. Grimberg, D’Arbra Blankenship, Joseph Mugasa, Kefas Mugittu, Lee Moore, Paul Gwakisa and Maciej Zborowski
Reference: 
Malaria Journal 2016 15:113, 24 February 2016

These findings provide strong evidence that MDM enhanced detection of sub-microscopic P. falciparum infections and estimation of gametocyte density compared to current malaria diagnostic tools.

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NOT Open Access | Reduction in symptomatic malaria prevalence through proactive community treatment in rural Senegal

October 6, 2015 - 09:02 -- NOT Open Access
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Author(s): 
Annē M. Linn, Youssoupha Ndiaye, Ian Hennessee, Seynabou Gaye, Patrick Linn, Karin Nordstrom and Matt McLaughlin
Reference: 
Tropical Medicine & International Health, Volume 20, Issue 11, pages 1438–1446, November 2015

This pilot study suggests that community-based proactive case detection reduces symptomatic malaria prevalence, likely through more timely case management and improved care seeking behaviour.

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Survival analysis of diagnostic assays in Plasmodium falciparum malaria

September 22, 2015 - 17:41 -- Open Access
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Author(s): 
Melissa Phuong, Rachel Lau, Filip Ralevski, Andrea Boggild
Reference: 
Malaria Journal 2015, 14:350 (17 September 2015)

Due to slow clearance of circulating antigen and DNA from bloodstream, RDT and qPCR have low positive predictive value for clinically relevant asexual parasitaemia in post-treatment specimens.

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Field deployment of loop-mediated isothermal amplification for centralized mass-screening of asymptomatic malaria in Zanzibar: a pre-elimination setting

May 22, 2015 - 12:51 -- Open Access
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Author(s): 
Ulrika Morris, Mwinyi Khamis, Jackie Cook, et al.
Reference: 
Malaria Journal 2015, 14:205 (17 May 2015)

LAMP is a simple and sensitive molecular tool, and has potential in active surveillance and mass-screening programmes for detection of low-density asymptomatic malaria in pre-elimination settings.

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Field evaluation of HRP2 and pan pLDH-based immunochromatographic assay in therapeutic monitoring of uncomplicated falciparum malaria in Myanmar

April 17, 2013 - 09:44 -- Open Access
Author(s): 
Nyunt MH, Kyaw MP, Win KK, Myint KM, Nyunt KM
Reference: 
Malaria Journal 2013, 12:123 (11 April 2013)
MalariaWorld

Although treatment monitoring cannot be performed by HRP2, it can be assessed by pan pLDH-based assay after day 3 if a gametocidal drug has been administered and after day 7 if the presence of gametocytes was not excluded.

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Safety of falciparum malaria diagnostic strategy based on rapid diagnostic tests in returning travellers and migrants: a retrospective study

November 20, 2012 - 06:43 -- Open Access
Author(s): 
Rossi IA, D'Acremont V, Prod'Hom G, Genton B
Reference: 
Malaria Journal 2012, 11:377 (16 November 2012)
MalariaWorld

A malaria diagnostic strategy based on RDTs and a delayed BS is safe in non-immune populations, and shortens the time to first malaria test result.

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