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Argemone Mexicana

Argemone Mexicana decoction versus artesunate-amodiaquine for the management of malaria in Mali: policy and public-health implications.

December 3, 2009 - 12:07 -- Patrick Sampao
Author(s): 
Bertrand Graz, Merlin L. Willcox, Chiaka Diakite, Jacques Falquet, Florent Dackuo, Oumar Sidibe, Sergio Giani, Drissa Diallo
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, Issue 1, January 2010, Pages 33-41, doi:10.1016/j.trstmh.2009.07.005

A classic way of delaying drug resistance is to use an alternative when possible. We tested the malaria treatment Argemone mexicana decoction (AM), a validated self-prepared traditional medicine made with one widely available plant and safe across wide dose variations. In an attempt to reflect the real situation in the home-based management of malaria in a remote Malian village, 301 patients with presumed uncomplicated malaria (median age 5 years) were randomly assigned to receive AM or artesunate-amodiaquine [artemisinin combination therapy (ACT)] as first-line treatment.

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