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protein kinases

Not Open Access | Activity of substituted thiophene sulfonamides against malarial and mammalian cyclin dependent protein kinases

June 14, 2012 - 10:13 -- Patrick Sampao
Author(s): 
Diana Caridha, April K. Kathcart, Dayadevi Jirage, Norman C. Waters
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 13, 1 July 2010, Pages 3863-3867

MalariaWorldIn this study, we identified thiophene and benzene sulfonamides as potent inhibitors of Pfmrk, a Plasmodium falciparum CDK with sequence homology to human CDK7. Several of the compounds demonstrated inhibitor selectivity for CDK7 over CDK1, CDK2, and CDK6.

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