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NK cells

Memory-like IFN- response by NK cells following malaria infection reveals the crucial role of T cells in NK cell activation by P. falciparum

November 26, 2010 - 13:21 -- Patrick Sampao
Author(s): 
Matthew B. B. McCall., Meta Roestenberg., Robert W. Sauerwein., et al.
Reference: 
European Journal of Immunology, Volume 40, Issue 12, pages 3472–3477, December 2010

Here, we studied the dynamics of and requirements for in vitro NK responses to PfRBC in malaria-naïve volunteers undergoing a single experimental malaria infection under highly controlled circumstances, and in naturally exposed individuals. NK-specific IFN-γ responses to PfRBC following exposure resembled an immunological recall pattern and were tightly correlated with T-cell responses.

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Comparing human T cell and NK cell responses in viral-based malaria vaccine trials

December 3, 2009 - 12:17 -- Patrick Sampao
Tags: 
Author(s): 
Tamara K. Berthoud, Helen Fletcher, David Porter, Fiona Thompson, Adrian V.S. Hill, Stephen M. Todryk
Reference: 
Vaccine, Volume 28, Issue 1, 10 December 2009, Pages 21-27

In conclusion, measuring antigen-specific T cells is more meaningful than NK cells in these vaccination regimens.

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