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NK cells

Memory-like IFN- response by NK cells following malaria infection reveals the crucial role of T cells in NK cell activation by P. falciparum

November 26, 2010 - 13:21 -- Patrick Sampao
Matthew B. B. McCall., Meta Roestenberg., Robert W. Sauerwein., et al.
European Journal of Immunology, Volume 40, Issue 12, pages 3472–3477, December 2010

Here, we studied the dynamics of and requirements for in vitro NK responses to PfRBC in malaria-naïve volunteers undergoing a single experimental malaria infection under highly controlled circumstances, and in naturally exposed individuals. NK-specific IFN-γ responses to PfRBC following exposure resembled an immunological recall pattern and were tightly correlated with T-cell responses.

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Comparing human T cell and NK cell responses in viral-based malaria vaccine trials

December 3, 2009 - 12:17 -- Patrick Sampao
Tamara K. Berthoud, Helen Fletcher, David Porter, Fiona Thompson, Adrian V.S. Hill, Stephen M. Todryk
Vaccine, Volume 28, Issue 1, 10 December 2009, Pages 21-27

In conclusion, measuring antigen-specific T cells is more meaningful than NK cells in these vaccination regimens.

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