Here, we studied the dynamics of and requirements for in vitro NK responses to PfRBC in malaria-naïve volunteers undergoing a single experimental malaria infection under highly controlled circumstances, and in naturally exposed individuals. NK-specific IFN-γ responses to PfRBC following exposure resembled an immunological recall pattern and were tightly correlated with T-cell responses.
European Journal of Immunology, Volume 40, Issue 12, pages 3472–3477, December 2010
Vaccine, Volume 28, Issue 1, 10 December 2009, Pages 21-27
In conclusion, measuring antigen-specific T cells is more meaningful than NK cells in these vaccination regimens.