chloroquine (CQ)

Antimalarial Activity and Mechanisms of Action of Two Novel 4-Aminoquinolines against Chloroquine-Resistant Parasites

Author(s):

Anna Caroline Campos Aguiar, Raquel de Meneses Santos, Flávio Júnior Barbosa Figueiredo, Wilian Augusto Cortopassi, André Silva Pimentel, Tanos Celmar Costa França, Mario Roberto Meneghetti, Antoniana Ursine Krettli

Reference:

PLoS ONE 7(5): e37259

MalariaWorld Chloroquine (CQ) is a cost effective antimalarial drug with a relatively good safety profile (or therapeutic index).

Medical Condition:

Medical Treatment:

Open Access | Genetic polymorphism of merozoite surface protein 2 and prevalence of K76T pfcrt mutation in Plasmodium falciparum field isolates from Congolese children with asymptomatic infections

Author(s):

Koukouikila-Koussounda F, Malonga V, Mayengue P, Ndounga M, Vouvoungui C, Ntoumi F

Reference:

Malaria Journal 2012, 11:105 (1 April 2012)

MalariaWorld This is the first molecular characterization of P. falciparum field isolates in Congolese children, four years after changing the malaria treatment policy from chloroquine (CQ) to artemisinin-based combination therapy (ACT).

Medical Condition:

Plasmodium falciparum

Medical Treatment:

artemisinin-based combination therapy (ACT

chloroquine (CQ)

Open Access | Large-scale survey for novel genotypes of Plasmodium falciparum chloroquine-resistance gene pfcrt

Author(s):

Takahashi N, Tanabe K, Tsukahara T, Dzodzomenyo M, Dysoley L, Khamlome B, Sattabongkot J, Nakamura M, Sakurai M, Kobayashi J, Kaneko A, Endo H, Hombhanje F, Tsuboi T, Mita T

Reference:

Malaria Journal 2012, 11:92 (28 March 2012)

MalariaWorld The number of CQ-mutant lineages observed in this study was identical to that found in previous studies.