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chloroquine (CQ)

Antimalarial Activity and Mechanisms of Action of Two Novel 4-Aminoquinolines against Chloroquine-Resistant Parasites

May 30, 2012 - 06:13 -- Kabogo Ndegwa
Author(s): 
Anna Caroline Campos Aguiar, Raquel de Meneses Santos, Flávio Júnior Barbosa Figueiredo, Wilian Augusto Cortopassi, André Silva Pimentel, Tanos Celmar Costa França, Mario Roberto Meneghetti, Antoniana Ursine Krettli
Reference: 
PLoS ONE 7(5): e37259

MalariaWorldChloroquine (CQ) is a cost effective antimalarial drug with a relatively good safety profile (or therapeutic index).

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Open Access | Genetic polymorphism of merozoite surface protein 2 and prevalence of K76T pfcrt mutation in Plasmodium falciparum field isolates from Congolese children with asymptomatic infections

April 4, 2012 - 14:15 -- Kabogo Ndegwa
Author(s): 
Koukouikila-Koussounda F, Malonga V, Mayengue P, Ndounga M, Vouvoungui C, Ntoumi F
Reference: 
Malaria Journal 2012, 11:105 (1 April 2012)

MalariaWorldThis is the first molecular characterization of P. falciparum field isolates in Congolese children, four years after changing the malaria treatment policy from chloroquine (CQ) to artemisinin-based combination therapy (ACT).

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Open Access | Large-scale survey for novel genotypes of Plasmodium falciparum chloroquine-resistance gene pfcrt

April 4, 2012 - 06:38 -- Kabogo Ndegwa
Author(s): 
Takahashi N, Tanabe K, Tsukahara T, Dzodzomenyo M, Dysoley L, Khamlome B, Sattabongkot J, Nakamura M, Sakurai M, Kobayashi J, Kaneko A, Endo H, Hombhanje F, Tsuboi T, Mita T
Reference: 
Malaria Journal 2012, 11:92 (28 March 2012)

MalariaWorldThe number of CQ-mutant lineages observed in this study was identical to that found in previous studies.

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Open Access | Ex vivo activity of the ACT new components pyronaridine and piperaquine in comparison with conventional ACT drugs against isolates of Plasmodium falciparum

February 21, 2012 - 06:42 -- Kabogo Ndegwa
Author(s): 
Pascual A, Parola P, Pradines B, et al.
Reference: 
Malaria Journal 2012, 11:45 (14 February 2012)

MalariaWorldIn this study, the excellent anti-malarial activity of PPQ and PND was confirmed.

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