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chloroquine (CQ)

Correlation of Molecular Markers, Pfmdr1-N86Y and Pfcrt-K76T, with In Vitro Chloroquine Resistant Plasmodium falciparum, Isolated in the Malaria Endemic States of Assam and Arunachal Pradesh, Northeast India

August 25, 2014 - 09:48 -- Open Access
Author(s): 
Sandeep Kumar Shrivastava, Ravi Kumar Gupta, Jagdish Mahanta, Mohan Lal Dubey
Reference: 
PLoS ONE 9(8): e103848

The mechanism of chloroquine (CQ) resistance in Plasmodium falciparum is not clearly understood.

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Use of proscribed chloroquine is associated with an increased risk of pfcrt t76 mutation in some parts of Ghana

July 3, 2014 - 11:58 -- Open Access
Author(s): 
Asare KK, Boampong JN, Afoakwah R, Ameyaw EO, Sehgal R, Quashie NB
Reference: 
Malaria Journal 2014, 13 :246 (26 June 2014)

This study has shown that high variation in the prevalence of T76 mutations of P. falciparum is linked with the level of CQ stocking and usage within study area.

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Not Open Access | Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite’s chloroquine resistance transporter

May 6, 2014 - 08:15 -- NOT Open Access
Author(s): 
Robert L. Summers, Anurag Dave, Rowena E. Martin, et al.
Reference: 
PNAS April 29, 2014 vol. 111 no. 17 E1759-E1767

Mutations in the chloroquine resistance transporter (PfCRT) are the primary determinant of chloroquine (CQ) resistance in the malaria parasite Plasmodium falciparum.

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Metabolic QTL Analysis Links Chloroquine Resistance in Plasmodium falciparum to Impaired Hemoglobin Catabolism

January 7, 2014 - 09:35 -- Open Access
Author(s): 
Ian A. Lewis, Mark Wacker, Kellen L. Olszewski, Simon A. Cobbold, Katelynn S. Baska, Asako Tan, Michael T. Ferdig, Manuel Llinás
Reference: 
PLoS Genet 10(1): e1004085

Drug resistant strains of the malaria parasite, Plasmodium falciparum, have rendered chloroquine ineffective throughout much of the world.

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Trends in chloroquine resistance marker, Pfcrt-K76T mutation ten years after chloroquine withdrawal in Tanzania

November 25, 2013 - 12:06 -- Open Access
Author(s): 
Mohammed A, Ndaro A, Kalinga A, Manjurano A, Mosha JF, Mosha DF, van Zwetselaar M, Koenderink JB, Mosha FW, Alifrangis M, Reyburn H, Roper C, Kavishe RA
Reference: 
Malaria Journal 2013, 12 :415 (14 November 2013)
MalariaWorld

CQ withdrawal in Tanzania has resulted into >90% recovery of susceptibility in ten years of withdrawal.

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In vitro chloroquine resistance for Plasmodium vivax isolates from the Western Brazilian Amazon

July 8, 2013 - 14:08 -- Open Access
Author(s): 
Chehuan YF, Costa MR, Costa JS, Alecrim MG, Nogueira F, Silveira H, Brasil LW, Melo GC, Monteiro WM, Lacerda MV
Reference: 
Malaria Journal 2013, 12:226 (3 July 2013)
MalariaWorld

In vitro CQ-resistance estimated in this study, estimated by the DELI test, was very similar to that observed in clinical trials, suggesting that in vitro procedures developed by capable local laboratories are useful in the surveillance of CQ-resistance in the Amazon; concurrent Amazon P. vivax strains with both CQ and MQ resistance may be common; and a non-synonymous mutation at pvdhps codon 382 (S[rightwards arrow]C) was associated to in vitro susceptibility to CQ, needing further studies to be confirmed.

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NOT Open Access | Efficacy of Dihydroartemisinin-Piperaquine for Treatment of Uncomplicated Plasmodium falciparum and Plasmodium vivax in Cambodia, 2008 to 2010

January 24, 2013 - 14:29 -- NOT Open Access
Author(s): 
Rithea Leang, Amy Barrette, Denis Mey Bouth, Didier Menard, Rashid Abdur, Socheat Duong, and Pascal Ringwald
Reference: 
Antimicrob. Agents Chemother. February 2013 vol. 57 no. 2 818-826
MalariaWorld

We describe here the results of antimalarial therapeutic efficacy studies conducted in Cambodia from 2008 to 2010.

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NOT Open Access | Antiplasmodial activities of 4-aminoquinoline–statine compounds

August 29, 2012 - 06:44 -- Kabogo Ndegwa
Author(s): 
Nadia Vaiana, Melissa Marzahn, Sergio Romeo, et al.
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 22, Issue 18, 15 September 2012, Pages 5915–5918

MalariaWorldWe report the discovery of new potent inhibitors of the growth of Plasmodium falciparum chloroquine (CQ)-resistant W2 strain.

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An Analytical Method for Assessing Stage-Specific Drug Activity in Plasmodium vivax Malaria: Implications for Ex Vivo Drug Susceptibility Testing

August 15, 2012 - 07:30 -- Kabogo Ndegwa
Author(s): 
Douglas H. Kerlin, Kane Boyce, Jutta Marfurt, Julie A. Simpson, Enny Kenangalem, Qin Cheng, Ric N. Price, Michelle L. Gatton
Reference: 
PLoS Negl Trop Dis 6(8): e1772

MalariaWorldThe emergence of highly chloroquine (CQ) resistant P. vivax in Southeast Asia has created an urgent need for an improved understanding of the mechanisms of drug resistance in these parasites, the development of robust tools for defining the spread of resistance, and the discovery of new antimalarial agents.

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NOT Open Access | Antiplasmodial potential of medicinal plant extracts from Malaiyur and Javadhu hills of South India

July 26, 2012 - 12:03 -- Kabogo Ndegwa
Author(s): 
Chinnaperumal Kamaraj, Naveen Kumar Kaushik, Dinesh Mohanakrishnan, Gandhi Elango, Asokan Bagavan, Abdul Abduz Zahir, Abdul Abdul Rahuman & Dinkar Sahal
Reference: 
Parasitology Research, Volume 111, Number 2 (2012), 703-715

In the present study, we found that 129S1 mice are resistant to the infection with Plasmodium yoelii 17XL, which is highly virulent and causes lethal infection in various strains of mice.The emergence and spread of Plasmodium falciparum with resistance to chloroquine (CQ), the safest and cheapest anti-malarial drug, coupled with the increasing cost of alternative drugs especially in developing countries have necessitated the urgent need to tap the potential of plants for novel anti-malarials.

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