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chloroquine (CQ)

NOT Open Access | 3-Iodo-4-aminoquinoline derivative sensitises resistant strains of Plasmodium falciparum to chloroquine

June 6, 2016 - 17:47 -- NOT Open Access
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Author(s): 
Sonia Edaye, Dagobert Tazoo, D. Scott Bohle, Elias Georges
Reference: 
International Journal of Antimicrobial Agents, Volume 47, Issue 6, June 2016, Pages 482–485

Chloroquine (CQ), the first cost-effective synthetic antimalarial, is rendered ineffective in malaria-endemic regions owing to the rise and spread of CQ-resistant Plasmodium falciparum.

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Plasmodium vivax mdr1 genotypes in isolates from successfully cured patients living in endemic and non-endemic Brazilian areas

February 23, 2016 - 16:48 -- Open Access
Author(s): 
Larissa Rodrigues Gomes, Natália Ketrin Almeida-de-Oliveira, Maria de Fatima Ferreira-da-Cruz, et al.
Reference: 
Malaria Journal 2016 15:96, 18 February 2016

Considering that primaquine (PQ) efficacy is highly dependent on concurrent administration of a blood schizontocidal agent and that PQ could not circumvent CQR, together with the fact that no pvmdr1 mutation should be expected in successfully cured patients, these findings seem to indicate that the pvmdr1 gene is not a reliable marker of CQR.

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Therapeutic efficacy of chloroquine for the treatment of Plasmodium vivax malaria among outpatients at Hossana Health Care Centre, southern Ethiopia

November 19, 2015 - 06:27 -- Open Access
Author(s): 
Mesfin Assefa, Teferi Eshetu, Abdissa Biruksew
Reference: 
Malaria Journal 2015, 14:458 (17 November 2015)

The current study revealed that CQ showed a high rate of efficacy (96.7 %) among the study participants even though some reports from previous studies elsewhere in Ethiopia showed an increase in CQR P. vivax.

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Chloroquine sensitivity: diminished prevalence of chloroquine-resistant gene marker pfcrt-76 13 years after cessation of chloroquine use in Msambweni, Kenya

August 25, 2015 - 06:22 -- Open Access
Author(s): 
William Kiarie, Laura Wangai, Eric Agola, Francis Kimani, Charity Hungu
Reference: 
Malaria Journal 2015, 14:328 (22 August 2015)

The results indicate a significant [χ 2 test, P ≤ 0.05 (2006 vs 2013)] reversal to sensitivity by the P. falciparum population in the study site compared to the situation reported in 2006 at the same study site.

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Resistance of infection by Plasmodium vivax to chloroquine in Bolivia

July 1, 2015 - 15:37 -- Open Access
Author(s): 
Arletta Añez, Manuel Moscoso, Ángel Laguna, Cecilia Garnica, Viviana Melgar, Mauren Cuba, Sonia Gutierrez, Carlos Ascaso
Reference: 
Malaria Journal 2015, 14:261 (1 July 2015)

The present study demonstrates the presence of resistance to CQ in the treatment of malaria by P. vivax in the Amazon region of Bolivia.

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Polymorphisms in chloroquine resistance-associated genes in Plasmodium vivax in Ethiopia

April 21, 2015 - 13:38 -- Open Access
Author(s): 
Lemu Golassa, Berhanu Erko, Frederick N Baliraine, Abraham Aseffa, Göte Swedberg
Reference: 
Malaria Journal 2015, 14:164 (16 April 2015)

High prevalence of mutations in candidate genes conferring CQR in P. vivax was identified.

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Studying the effect of chloroquine on sporozoite-induced protection and immune responses in Plasmodium berghei malaria

March 31, 2015 - 17:33 -- Open Access
Author(s): 
Else M Bijker, Krystelle Nganou-Makamdop, Geert-Jan van Gemert, Fidel Zavala, Ian Cockburn, Robert W Sauerwein
Reference: 
Malaria Journal 2015, 14:130 (26 March 2015)

This study does not provide evidence for a direct beneficial effect of CQ on the induction of sporozoite-induced immune responses and protection in P. berghei malaria models.

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NOT Open Access | Reemergence of chloroquine (CQ) analogs as multi-targeting antimalarial agents: A review

January 12, 2015 - 15:24 -- NOT Open Access
Author(s): 
Mushtaque, Shahjahan
Reference: 
European Journal of Medicinal Chemistry, Volume 90, 27 January 2015, Pages 280–295

Amongst several communicable diseases (CDs), malaria is one of the deadliest parasitic disease all over the world, particularly in African and Asian countries.

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Antiplasmodial activity of chloroquine analogs against chloroquine-resistant parasites, docking studies and mechanisms of drug action

December 12, 2014 - 06:43 -- Open Access
Author(s): 
Nicolli B de Souza, Arturene ML Carmo, Adilson D da Silva, Tanos CC França, Antoniana U Krettli
Reference: 
Malaria Journal 2014, 13:469 (2 December 2014)

The presence of an alkyne group and the size of the side chain affected anti-P. falciparum activity in vitro.

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Efficacy and safety of a combination of azithromycin and chloroquine for the treatment of uncomplicated Plasmodium falciparum malaria in two multicountry randomized clinical trials in African adults

December 10, 2014 - 16:20 -- Open Access
Author(s): 
Issaka Sagara, Abraham R Oduro, Michael W Dunne, et al.
Reference: 
Malaria Journal 2014, 13:458 (25 November 2014)

Among adults with symptomatic uncomplicated falciparum malaria in Africa, the combination of AZ 1,000 mg and CQ 600-mg base once daily for three days resulted in Day-28 PCR-corrected parasitological clearance rates of >=98% and was non-inferior to treatment with MQ. AZCQ was well tolerated.

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