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chloroquine (CQ)

NOT Open Access | Monitoring the Efficacy of Chloroquine-Primaquine Therapy for Uncomplicated Plasmodium vivax Malaria in the Main Transmission Hot Spot of Brazil

April 30, 2019 - 15:20 -- NOT Open Access
Author(s): 
Simone Ladeia-Andrade, Maria José Menezes, Taís Nóbrega de Sousa, Ana Carolina R. Silvino, Jaques F. de Carvalho Jr., Laís C. Salla, Odaílton A. Nery, Gladson N. P. de Melo, Rodrigo M. Corder, Priscila T. Rodrigues and Marcelo U. Ferreira
Reference: 
Antimicrob. Agents Chemother. April 2019 63:e01965-18

Emerging Plasmodium vivax resistance to chloroquine (CQ) may undermine malaria elimination efforts in South America. CQ-resistant P. vivax has been found in the major port city of Manaus but not in the main malaria hot spots across the Amazon Basin of Brazil, where CQ is routinely coadministered with primaquine (PQ) for radical cure of vivax malaria. Here we randomly assigned 204 uncomplicated vivax malaria patients from Juruá Valley, northwestern Brazil, to receive either sequential (arm 1) or concomitant (arm 2) CQ-PQ treatment.

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NOT Open Access | High-Content Screening of the Medicines for Malaria Venture Pathogen Box for Plasmodium falciparum Digestive Vacuole-Disrupting Molecules Reveals Valuable Starting Points for Drug Discovery

February 28, 2018 - 14:40 -- NOT Open Access
Author(s): 
Jie Xin Tong, Rajesh Chandramohanadas and Kevin Shyong-Wei Tan
Reference: 
Antimicrob. Agents Chemother. March 2018 vol. 62 no. 3 e02031-17

Plasmodium falciparum infections leading to malaria have severe clinical manifestations and high mortality rates.

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Drug resistance genes: pvcrt-o and pvmdr-1 polymorphism in patients from malaria endemic South Western Coastal Region of India

January 22, 2018 - 16:01 -- Open Access
Author(s): 
Shiny Joy, Benudhar Mukhi, Susanta K. Ghosh, Rajeshwara N. Achur, D. Channe Gowda and Namita Surolia
Reference: 
Malaria Journal 2018 17:40, 19 January 2018

The observed variations both in pvmdr-1 and pvcrt-o genes indicate a trend towards parasite acquiring CQ resistance in this endemic area.

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NOT Open Access | Optimal antimalarial dose regimens for chloroquine in pregnancy based on population pharmacokinetic modelling

October 12, 2017 - 15:14 -- NOT Open Access
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Author(s): 
Sam Salman, Francesca Baiwog, Timothy M.E. Davis, et al.
Reference: 
International Journal of Antimicrobial Agents, Volume 50, Issue 4, October 2017, Pages 542-551

Despite extensive use and accumulated evidence of safety, there have been few pharmacokinetic studies from which appropriate chloroquine (CQ) dosing regimens could be developed specifically for pregnant women.

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NOT Open Access | Therapeutic efficacy of chloroquine for the treatment of Plasmodium vivax malaria among outpatients at Shawa Robit Health Care Centre, North-East Ethiopia

June 20, 2017 - 14:33 -- NOT Open Access
Author(s): 
Seble Seifu, Ahmed Zeynudin, Endalew Zemene, Sultan Suleman, Abdissa Biruksew
Reference: 
Acta Tropica, Volume 171, July 2017, Pages 44–51

Nearly 40% of all malaria infection in Ethiopia is caused by Plasmodium vivax. Chloroquine (CQ) is the first line treatment for confirmed P. vivax malaria in the country.

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Prevalence of crt and mdr-1 mutations in Plasmodium falciparum isolates from Grande Comore island after withdrawal of chloroquine

August 23, 2016 - 16:32 -- Open Access
Author(s): 
Bo Huang, Qi Wang, Jianping Song, et al.
Reference: 
Malaria Journal 2016 15:414, 15 August 2016

The present data indicate that the prevalence and patterns of mutant pfcrt and pfmdr-1 dramatically decreased in the Grande Comore isolates from 2006 to 2014, suggesting that the CQ-sensitive P. falciparum strains have returned after the withdrawal of CQ.

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NOT Open Access | Molecular markers associated with resistance to commonly used antimalarial drugs among Plasmodium falciparum isolates from a malaria-endemic area in Taiz governorate—Yemen during the transmission season

August 9, 2016 - 07:45 -- NOT Open Access
Author(s): 
Lina M.Q. Alareqi, Mohammed A.K. Mahdy, Yee-Ling Lau, Mun-Yik Fong, Rashad Abdul-Ghani, Rohela Mahmud
Reference: 
Acta Tropica, Volume 162, October 2016, Pages 174–179

Since 2005, artesunate (AS) plus sulfadoxine/pyrimethamine (SP) combination has been adopted as the first-line treatment for uncomplicated malaria in Yemen in response to the high level of Plasmodium falciparum resistance to chloroquine (CQ).

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Molecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite’s Chloroquine Resistance Transporter

August 1, 2016 - 10:58 -- Open Access
Author(s): 
Sashika N. Richards, Megan N. Nash, Eileen S. Baker, Michael W. Webster, Adele M. Lehane, Sarah H. Shafik, Rowena E. Martin
Reference: 
PLoS Pathog 12(7): e1005725

Mutations in the Plasmodium falciparum ‘chloroquine resistance transporter’ (PfCRT) confer resistance to chloroquine (CQ) and related antimalarials by enabling the protein to transport these drugs away from their targets within the parasite’s digestive vacuole (DV).

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Evaluation of the paediatric dose of chloroquine in the treatment of Plasmodium vivax malaria

July 23, 2016 - 17:13 -- Open Access
Author(s): 
Arletta Añez, Manuel Moscoso, Cecilia Garnica and Carlos Ascaso
Reference: 
Malaria Journal 2016 15:371, 19 July 2016

A CQ dose of 25 mg/kg for the treatment of P. vivax malaria may be too low in children as demonstrated by the reduction in CQ concentrations in blood at day 7 of follow-up.

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Improved malaria case management in formal private sector through public private partnership in Ethiopia: retrospective descriptive study

July 12, 2016 - 17:16 -- Open Access
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Author(s): 
Mesele D. Argaw, Asfawesen GY. Woldegiorgis, Derebe T. Abate and Mesfin E. Abebe
Reference: 
Malaria Journal 2016 15:352, 11 July 2016

This study documented the chronological changes of adherence of health care providers with the national recommended standards to treat malaria.

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