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Recent Advances in Plasmepsin Medicinal Chemistry and Implications for Future Antimalarial Drug Discovery Efforts

February 22, 2012 - 15:01 -- Patrick Sampao
J. Meyers, Marvin; E. Goldberg, Daniel
Current Topics in Medicinal Chemistry, Volume 12, Number 5, March 2012 , pp. 445-455(11)

MalariaWorldThis review will highlight some of the recent work in this field with a particular focus on target druggability and strategies for identifying plasmepsins inhibitors as effective antimalarial drugs.

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Role of Plasmodium falciparum Digestive Vacuole Plasmepsins in the Specificity and Antimalarial Mode of Action of Cysteine and Aspartic Protease Inhibitors

December 7, 2009 - 11:51 -- Ingeborg van Schayk
Pedro A. Moura, John B. Dame, and David A. Fidock
Antimicrob. Agents Chemother. 2009;53 4968-4978

Hemoglobin (Hb) degradation is essential for the growth of the intraerythrocytic stages of malarial parasites.

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