High spatial variability can substantially reduce the effectiveness of a national level test and treat malaria policy.
rapid diagnostic test (RDT)
Malaria infection was common and well correlated among pregnant women and infants attending routine health services.
In the Ethiopia setting, an MTAT intervention is operationally feasible and can be conducted with high coverage.
This highly diverse parasite population suggests a high degree of transmissibility and coupled with the substantial proportion of low-density infections, may pose challenges for malaria control and elimination efforts.
The malaria prevalence among the children and the presence of four Plasmodium species, highlighted in this study, identified a sanitary issue which proved to be more alarming than expected, as it was worsened by the unpredictable presence of P. vivax and Babesia microti (never before reported in DRC).
The qRT-PCR assay is sufficiently sensitive to identify an unexpectedly large number of asymptomatic, submicroscopic infections.
The relationships defined in this research can be applied to RDT-derived PfPR data to effectively convert them to an estimate of the parasite prevalence expected using microscopy (or vice versa), thereby standardizing the dataset and improving the signal-to-noise ratio.
In this highland site in western Kenya malaria transmission was low, but highly heterogeneous.
The LAMP assay could produce reliable results the same day of the screening.
Despite low levels of resistance to SP in the study areas, ISTp-AL performed as well as IPTp-SP.