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rapid diagnostic test (RDT)

Evaluating 18s-rRNA LAMP and selective whole genome amplification (sWGA) assay in detecting asymptomatic Plasmodium falciparum infections in blood donors

July 1, 2019 - 15:42 -- Open Access
Author(s): 
Enoch Aninagyei, Stella Smith-Graham, Alex Boye, Alexander Egyir-Yawson and Desmond Omane Acheampong
Reference: 
Malaria Journal 2019 18:214, 24 June 2019

Undesirable consequences of donor Plasmodium falciparum parasitaemia on stored donor blood have been reported. Therefore, it is imperative that all prospective blood donors are screened for P. falciparum infections using sensitive techniques. In this study, the sensitivities of microscopy, rapid diagnostic test (RDT), loop-mediated isothermal amplification (LAMP) assay and selective whole genome amplification (sWGA) technique in detecting P. falciparum infections in blood donors was assessed.

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Does anthropometric status at 6 months predict the over-dispersion of malaria infections in children aged 6–18 months? A prospective cohort study

April 23, 2019 - 13:16 -- Open Access
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Author(s): 
Jaden Bendabenda, Noel Patson, Lotta Hallamaa, Ulla Ashorn, Kathryn G. Dewey, Per Ashorn and Kenneth Maleta
Reference: 
Malaria Journal 2019 18:143, 22 April 2019

In children aged 6–18 months living in malaria-endemic settings, LAZ, WAZ, and WLZ do not predict malaria incidence.

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Malaria testing and treatment knowledge among selected rural patent and proprietary medicine vendors (PPMV) in Nigeria

March 27, 2019 - 16:06 -- Open Access
Author(s): 
Oladimeji Oladepo, Abisoye S. Oyeyemi, Musibau A. Titiloye, Adedayo O. Adeyemi, Sarah M. Burnett, Iorwakwagh Apera, Opeyemi Oladunni and Michael Alliu
Reference: 
Malaria Journal 2019 18:103, 27 March 2019

Substantial knowledge gaps on the use of RDTs and treatment with artemisinin-based combinations exist among rural PPMVs.

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Prevalence of Plasmodium parasitaemia in blood donors and a survey of the knowledge, attitude and practices of transfusion malaria among health workers in a hospital in Kumasi, Ghana

November 21, 2018 - 15:22 -- Open Access
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Author(s): 
Kwame Agyemang Adusei, Alex Owusu-Ofori
Reference: 
PLoS ONE 13(11): e0206303

Malaria is one of the transfusion transmissible infections in malaria endemic countries such as Ghana.

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Prospective comparative multi-centre study on imported Plasmodium ovale wallikeri and Plasmodium ovale curtisi infections

October 31, 2018 - 15:34 -- Open Access
Author(s): 
Gerardo Rojo-Marcos, José Miguel Rubio-Muñoz, José Llovo‑Taboada, et al.
Reference: 
Malaria Journal 2018 17:399, 30 October 2018

Imported P. o. wallikeri infection may be more frequent in males and Caucasians.

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Diagnostic accuracy of loop-mediated isothermal amplification (LAMP) for screening malaria in peripheral and placental blood samples from pregnant women in Colombia

July 17, 2018 - 15:52 -- Open Access
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Author(s): 
Ana María Vásquez, Lina Zuluaga, Alberto Tobón, Maritza Posada, Gabriel Vélez, Iveth J. González, Ana Campillo and Xavier Ding
Reference: 
Malaria Journal 2018 17:262, 13 July 2018

LAMP is a simple, rapid and accurate molecular tool for detecting gestational and placental malaria, being able to overcome the limited sensitivity of LM and RDT.

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Prevalence and risk factors for asymptomatic malaria and genotyping of glucose 6-phosphate (G6PD) deficiencies in a vivax-predominant setting, Lao PDR: implications for sub-national elimination goals

June 5, 2018 - 14:40 -- Open Access
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Author(s): 
Andrew A. Lover, Emily Dantzer, Bouasy Hongvanthong, Keobouphaphone Chindavongsa, Susie Welty, Tania Reza, Nimol Khim, Didier Menard and Adam Bennett
Reference: 
Malaria Journal 2018 17:218, 1 June 2018

This is the first rigorous PCR-based population survey for malaria infection in Northern Lao PDR, and found a very low prevalence of asymptomatic Plasmodium infections by standard PCR methods, with P. vivax predominating in the surveyed districts.

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Phosphoethanolamine-N-methyltransferase is a potential biomarker for the diagnosis of P. knowlesi and P. falciparum malaria

March 20, 2018 - 14:28 -- Open Access
Author(s): 
Robert G. E. Krause, J. P. Dean Goldring
Reference: 
PLoS ONE 13(3): e0193833

PMT, like the pan-specific LDH biomarker used in RDT tests, is both soluble, present at comparable concentrations in the parasite and constitutes a promising antimalarial drug target.

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Plasmodium falciparum diagnostic tools in HIV-positive under-5-year-olds in two ART clinics in Ghana: are there missed infections?

February 27, 2018 - 15:42 -- Open Access
Author(s): 
Ewurama D. A. Owusu, Samson K. Djonor, Charles A. Brown, Martin P. Grobusch and Petra F. Mens
Reference: 
Malaria Journal 2018 17:92, 23 February 2018

Circulation of malaria parasites with pfrhp2/3 deletions in this population played a role in missed infections with RDT.

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Evaluation of the Deki Reader™, an automated RDT reader and data management device, in a household survey setting in low malaria endemic southwestern Uganda

November 13, 2017 - 15:23 -- Open Access
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Author(s): 
Caesar Oyet, Michelle E. Roh, Gertrude N. Kiwanuka, Patrick Orikiriza, Martina Wade, Sunil Parikh, Juliet Mwanga-Amumpaire and Yap Boum II
Reference: 
Malaria Journal 2017 16:449, 7 November 2017

The findings from this study suggest that the Deki Reader™ is comparable to visual inspection and performs well in detecting microscopy-positive Plasmodium falciparum cases in a household survey setting.

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