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amodiaquine (AQ)

Not Open Access | Novel anti-adipogenic activity of anti-malarial amodiaquine through suppression of PPARγ activity

November 5, 2017 - 18:29 -- NOT Open Access
Author(s): 
Tae Hee Kim, Hyo Kyeong Kim, Eun Sook Hwang
Reference: 
Archives of Pharmacal Research October 25

Amodiaquine (AQ) was developed as a selective drug against Plasmodium falciparum malaria infection and has received increasing attention as a therapeutic agent for the treatment of rheumatoid arthritis, Parkinson’s disease, and cancer due to its anti-inflammatory, anti-proliferative, and autophagic–lysosomal blockade properties.

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NOT Open Access | Cytochrome 1A1 and 1B1 gene diversity in the Zanzibar islands

June 26, 2012 - 08:49 -- Kabogo Ndegwa
Author(s): 
I. Cavaco, R. Piedade, M. I. Msellem, A. Bjorkman and J. P. Gil
Reference: 
Tropical Medicine & International Health, Volume 17, Issue 7, pages 854–857, July 2012

MalariaWorldAmodiaquine (AQ) is a 4-aminoquinoline widely used in the treatment of malaria as part of the artemisinin combination therapy (ACT).

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Open Access | Artesunate-amodiaquine fixed dose combination for the treatment of Plasmodium falciparum malaria in India

April 4, 2012 - 12:09 -- Kabogo Ndegwa
Author(s): 
Anvikar AR, Sharma B, Shahi BH, Tyagi PK, Bose TK, Sharma SK, Srivastava P, Srivastava B, Kiechel JR, Dash AP, Valecha N
Reference: 
Malaria Journal 2012, 11:97 (30 March 2012)

MalariaWorldThe fixed dose combination of ASAQ was found to be efficacious and safe treatment for P. falciparum malaria.

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In vitro amodiaquine resistance and its association with mutations in pfcrt and pfmdr1 genes of Plasmodium falciparum isolates from Nigeria

October 25, 2011 - 08:19 -- Kabogo Ndegwa
Author(s): 
O.A. Folarin, C. Bustamante, G.O. Gbotosho, A. Sowunmi, M.G. Zalis, A.M.J. Oduola, C.T. Happi
Reference: 
Acta Tropica, Volume 120, Issue 3, December 2011, Pages 224-230

MalariaWorldResults from this study suggest that polymorphisms in pfcrt and pfmdr1 genes are important for AQ resistance and therefore may be useful for epidemiological surveillance of P. falciparum resistance to AQ.

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