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Immunization with the RTS,S/AS malaria vaccine induces IFN-γ +CD4 T cells that recognize only discrete regions of the circumsporozoite protein and these specificities are maintained following booster immunizations and challenge

October 24, 2011 - 15:13 -- Patrick Sampao
Robert Schwenk, Joanne M. Lumsden, Lisa E. Rein, Laure Juompan, Kent E. Kester, D. Gray Heppner, Urszula Krzych
Vaccine, Volume 29, Issue 48, 8 November 2011, Pages 8847-8854

MalariaWorldWe conclude that processing of the CS protein derived from the RTS,S antigen leads to the generation of HLA-DR-restricted epitopes that are similar to those identified previously using CD4 T cells from subjects immunized with and protected by attenuated sporozoites or exposed to infectious sporozoites.

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