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erythrocyte

Differences in Erythrocyte Receptor Specificity of Different Parts of the Plasmodium falciparum Reticulocyte Binding Protein Homologue 2a

July 26, 2011 - 12:48 -- Patrick Sampao
Author(s): 
Karthigayan Gunalan, Xiaohong Gao, Kingsley J. L. Liew, and Peter R. Preiser
Reference: 
Infect. Immun., Aug 2011; 79: 3421 - 3430.

Here, using monoclonal antibodies raised against a unique region of PfRH2a, we show that PfRH2a moves from the rhoptry neck to the moving junction during merozoite invasion.

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Red Cells, Iron, and Erythropoiesis: Interactions with heparin-like molecules during erythrocyte invasion by Plasmodium falciparum merozoites

June 7, 2010 - 09:06 -- Patrick Sampao
Author(s): 
Michelle J. Boyle, Jack S. Richards, Paul R. Gilson, Wengang Chai, and James G. Beeson
Reference: 
Blood, Jun 2010; 115: 4559 - 4568.

All P falciparum isolates tested, and parasites using different invasion pathways were inhibited to comparable levels. Furthermore, it was not possible to select for heparin-resistant parasites. Heparin-like molecules occur naturally on the surface of human erythrocytes, where they may act as receptors for binding of merozoite surface proteins.

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Inhibition of Erythrocyte Invasion and Plasmodium falciparum Merozoite Surface Protein 1 Processing by Human Immunoglobulin G1 (IgG1) and IgG3 Antibodies

December 7, 2009 - 11:26 -- Ingeborg van Schayk
Author(s): 
Maria Lazarou, Jose A. Guevara Patino, Richard M. Jennings, Richard S. McIntosh, Jianguo Shi, Steven Howell, Eilish Cullen, Tarran Jones, Jaime R. Adame-Gallegos, Jonathan A. Chappel, Jana S. McBride, Michael J. Blackman, Anthony A. Holder, and Richard J. Pleass
Reference: 
Infect. Immun. 2009;77 5659-5667

Antigen-specific antibodies (Abs) to the 19-kDa carboxy-terminal region of Plasmodium falciparum merozoite surface protein 1 (MSP119) play an important role in protective immunity to malaria.

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