protein

Peptide inhibitors of the malaria surface protein, apical membrane antigen 1: Identification of key binding residues

Author(s):

Erinna F. Lee., Shenggen Yao., Raymond S. Norton., et al.

Reference:

Biopolymers, Volume 95, Issue 5, pages 354–364, May 2011

The peptide was expressed as a fusion protein following replacement of Met16 by Leu in order to accommodate cyanogen bromide cleavage. This modified peptide (R2) displayed the same affinity for AMA1 as R1, showing that the identity of the side chain at position 16 was not critical for binding.

Medical Condition:

Medical Treatment:

Open Access | Invited Speaker Presentation: A common protein export pathway in malaria parasites

Author(s):

Brendan Crabb, Hayley Bullen, Sarah Charnaud, Silvia Haase, Justin Boddey, Alan Cowman, Tania de Koning-Ward, Paul Gilson

Reference:

Malaria Journal 2010, 9(Suppl 2):I3 (20 October 2010)

Protozoan parasites that cause malaria export hundreds of proteins into their host red blood cell cytosol, and some even beyond that to the extracellular environment.

Medical Condition:

Medical Treatment:

Poly(I:C) is an effective adjuvant for antibody and multi-functional CD4+ T cell responses to Plasmodium falciparum circumsporozoite protein (CSP) and αDEC-CSP in non human primates

Author(s):

Kavita T., Barbara J., et al.

Reference:

Vaccine, Volume 28, Issue 45, 21 October 2010, Pages 7256-7266

Here to assess these variables, non human primates (NHP) were immunized three times with Plasmodium falciparum (Pf) circumsporozoite protein (CSP) or CSP cloned into MG38, a monoclonal antibody that targets DEC-205 (αDEC-CSP), an endocytic receptor on dendritic cells (DCs).

Medical Condition:

Plasmodium falciparum

Medical Treatment:

Identification of a role for the PfEMP1 semi-conserved head structure in protein trafficking to the surface of Plasmodium falciparum infected red blood cells

Author(s):

Martin M., Rebecca A., et al.

Reference:

Cellular Microbiology, Volume 12, Issue 10, pages 1446–1462, October 2010

This study establishes a new system to investigate PfEMP1 transport and demonstrates that the PfEMP1 semi-conserved head structure is under selection for protein transport, in addition to its known roles in adhesion.

Medical Condition:

Medical Treatment:

Short Communication: Purified Plasmodium falciparum multi-drug resistance protein (PfMDR 1) binds a high affinity chloroquine analogue

Author(s):

Perri Pleeter, Jacqueline K. Lekostaj, Paul D. Roepe

Reference:

Molecular and Biochemical Parasitology, Volume 173, Issue 2, October 2010, Pages 158-161

We utilize the recent successful overexpression of recombinant Plasmodium falciparum multi-drug resistance transporter, purification and reconstitution of the protein, and a novel high affinity chloroquine analogue to probe hypothesized interaction between the transporter and quinoline drugs.

Medical Condition:

Plasmodium falciparum

Medical Treatment:

Arp1, an actin-related protein, in Plasmodium berghei

Author(s):

Inga Siden-Kiamos, Herwig Schüler, Dimitris Liakopoulos, Christos Louis

Reference:

Molecular and Biochemical Parasitology, Volume 173, Issue 2, October 2010, Pages 88-96

We present a phylogenetic and three-dimensional modelling analysis as well as cell biological and genetic data that support classification of this gene as being an orthologue of the actin-related protein 1 (Arp1).

Medical Condition:

Medical Treatment:

Open Access | Cerebral malaria: insights from host-parasite protein-protein interactions

Author(s):

Rao A, Kumar MK, Joseph T, Bulusu G

Reference:

Malaria Journal 2010, 9:155 (9 June 2010)

This work links key host-parasite, parasite-parasite and host-host protein-protein interactions to key processes of cerebral malaria and generates hypotheses for disease pathogenesis based on a filtered interaction dataset.

Medical Condition:

Medical Treatment:

Evidence for negative selection on the gene encoding rhoptry-associated protein 1 (RAP-1) in Plasmodium spp.

Author(s):

Elizabeth M. R., Amanda C. P., et al.

Reference:

Infection, Genetics and Evolution, Volume 10, Issue 5, July 2010, Pages 655-661

We investigated the genetic diversity of orthologous genes encoding the rhoptry-associated protein 1 (RAP-1), a low polymorphic protein of malarial parasites that is involved in erythrocyte invasion.

Medical Condition:

Medical Treatment:

Vaccine Potentials of an Intrinsically Unstructured Fragment Derived from the Blood Stage-Associated Plasmodium falciparum Protein PFF0165c

Author(s):

S. Olugbile, C. Kulangara, G. Bang, S. Bertholet, E. Suzarte, V. Villard, G. Frank, R. Audran, A. Razaname, I. Nebie, O. Awobusuyi, F. Spertini, A. V. Kajava, I. Felger, P. Druilhe, and G. Corradin

Reference:

Infect. Immun. 2009;77 5701-5709

We have identified new malaria vaccine candidates through the combination of bioinformatics prediction of stable protein domains in the Plasmodium falciparum genome, chemical synthesis of polypeptides, in vitro biological functional assays, and association of an antigen-specific antibody response with protection against clinical malaria.

Medical Condition:

Plasmodium falciparum

Medical Treatment:

vaccine

protein

PFF0165c

Search form

You are here