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apical membrane

Apical Membrane Antigen 1 as an Anti-Malarial Drug Target

August 3, 2011 - 09:02 -- Patrick Sampao
Author(s): 
A. MacRaild, Christopher; F. Anders, Robin; Foley, Michael; S. Norton, Raymond
Reference: 
Current Topics in Medicinal Chemistry, Volume 11, Number 16, August 2011 , pp. 2039-2047(9)

Here we review both the structural details and functional significance of interactions at the hydrophobic cleft of AMA1, and argue that this feature of the protein represents an excellent target for the development of drugs that would block host cell invasion by malarial parasites.

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