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quinoxaline derivatives

New ferrocenic pyrrolo[1,2-a]quinoxaline derivatives: Synthesis, and in vitro antimalarial activity – Part II

May 4, 2011 - 12:54 -- Kabogo Ndegwa
Jean Guillon, Elisabeth Mouray, Philippe Grellier, et al.
European Journal of Medicinal Chemistry, Volume 46, Issue 6, June 2011, Pages 2310-2326

Following our search for antimalarial compounds, novel series of ferrocenyl-substituted pyrrolo[1,2-a]quinoxalines 1-2 were synthesized from ferrocene-carboxaldehyde and tested for their in vitro activity upon the erythrocytic development of Plasmodium falciparum strains with different chloroquine-resistance status.

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